Cytogenetics of Human Small Cell Lung Cancer
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The combination of chemo- and radiotherapy has resulted in prolonged survival and potential cures in patients with some neoplastic diseases. Small cell lung cancer (SCLC) is one of those neoplasms in which over 90% of the patients respond favorably to treatment, about 10% being cured. However, patients with non-small-cell lung cancer (non-SCLC) have a much lower response rate to current therapeutic regimens. Therefore, accurate diagnosis is extremely important. With the advent of chromosome banding techniques in the early 1970s (Caspersson et al. 1968; Seabright 1971), it became possible to identify chromosomal abnormalities that were specific for certain neoplastic diseases, including the Philadelphia or Ph1 chromosome in chronic myelogenous leukemia (CML) (Nowell and Hungerford 1960), t(15;17) in acute progranulocytic leukemia (APL) (Rowley et al. 1977), t(8;14) in Burkitt’s lymphoma (Zech et al. 1976), t(14;18) in follicular lymphoma (Yunis et al. 1982), deletion 13q14 in retinoblastoma (Yunis and Ramsey 1978), deletion 11p14 in Wilm’s triad syndrome (Miller 1977), and deletion 6q in melanoma (Trent et al. 1983; Becher et al. 1983). Here we wish to describe a specific chromosomal marker, deletion (3)(p14–23), that is associated with and diagnostic of SCLC.
KeywordsSmall Cell Lung Cancer Herpes Simplex Virus Type Interstitial Deletion Continuous Cell Line Small Cell Lung Cancer Patient
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