Advertisement

Cytogenetics of Human Small Cell Lung Cancer

  • J. Whang-Peng
  • E. C. Lee
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 97)

Abstract

The combination of chemo- and radiotherapy has resulted in prolonged survival and potential cures in patients with some neoplastic diseases. Small cell lung cancer (SCLC) is one of those neoplasms in which over 90% of the patients respond favorably to treatment, about 10% being cured. However, patients with non-small-cell lung cancer (non-SCLC) have a much lower response rate to current therapeutic regimens. Therefore, accurate diagnosis is extremely important. With the advent of chromosome banding techniques in the early 1970s (Caspersson et al. 1968; Seabright 1971), it became possible to identify chromosomal abnormalities that were specific for certain neoplastic diseases, including the Philadelphia or Ph1 chromosome in chronic myelogenous leukemia (CML) (Nowell and Hungerford 1960), t(15;17) in acute progranulocytic leukemia (APL) (Rowley et al. 1977), t(8;14) in Burkitt’s lymphoma (Zech et al. 1976), t(14;18) in follicular lymphoma (Yunis et al. 1982), deletion 13q14 in retinoblastoma (Yunis and Ramsey 1978), deletion 11p14 in Wilm’s triad syndrome (Miller 1977), and deletion 6q in melanoma (Trent et al. 1983; Becher et al. 1983). Here we wish to describe a specific chromosomal marker, deletion (3)(p14–23), that is associated with and diagnostic of SCLC.

Keywords

Small Cell Lung Cancer Herpes Simplex Virus Type Interstitial Deletion Continuous Cell Line Small Cell Lung Cancer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arrighi FW, Hsu TC (1971) Localization of heterochromatin in human chromosomes. Cytogenetics 10: 81–86PubMedCrossRefGoogle Scholar
  2. Becher R, Gibas Z, Sandberg AA (1983) Chromosome 6 in malignant melanoma. Cancer Genet Cytogenet 9: 173–175PubMedCrossRefGoogle Scholar
  3. Biedler JL, Spengler BA (1976) A novel chromosome abnormality in human neuroblastoma and anti-folate resistant chinese hamster cell lines in culture. J Natl Cancer Inst 57: 683–695PubMedGoogle Scholar
  4. Carney DN, Bunn PA, Gazdar AF, Pagen JA, Minna JD (1981) Selective growth in serum free, hormone supplemented medium of tumor cells obtained by biopsy from patients with small cell carcinoma of the lung. Proc Natl Acad Sci USA 78: 3185–3189PubMedCrossRefGoogle Scholar
  5. Carrit B, Goldfarb P (1976) A human chromosome determinant for susceptibility to herpes simplex virus. Nature 264: 556–558CrossRefGoogle Scholar
  6. Caspersson T, Farber S, Foley GE, Kudynowski J, Mosest EJ, Simonsson E, Wagh U, Zech L (1968) Chemical differentiation along metaphase chromosomes. Exp Cell Res 49: 219–222PubMedCrossRefGoogle Scholar
  7. Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SC, Brown RS (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Med 301: 592–595PubMedCrossRefGoogle Scholar
  8. Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Antoniades (1983) Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221: 275–277PubMedCrossRefGoogle Scholar
  9. Francke U, Francke BR (1979) Assignment of gene(s) required for herpes simplex virus Type I (HVIS) replication to the long arm of chromosome 11. Human gene mapping 5: fifth international workshop on human gene mapping. Birth Defects: Original Article Series XV: 11, 1979. The National Foundation, New York, p 550Google Scholar
  10. Gazdar AF, Carney DN, Russell EK, Sims HL, Baylin SB, Bunn PA, Guccion JG, Minna JD (1980) Establishment of continuous clonable cultures of small-cell carcinoma of the lung which have amine precursor uptake and decarboxylation cell properties. Cancer Res 40: 3502–3507PubMedGoogle Scholar
  11. Jhanwar SC, Neel BG, Hayward WS, Chaganti RSK (1983) Localization of c-ras oncogene family on human germline chromosomes. Proc Natl Acad Sci USA 80: 474–491CrossRefGoogle Scholar
  12. Luthardt FW (1982) In vitro induced expression of genomic “hot spot” at 3p14. (abstract) Abstract of the thirty-third annual meeting of the American Society of Human Genetics, p 134AGoogle Scholar
  13. Miller RW (1977) Cancer and congenital malformation: another view. In: Mulvihill JJ, Miller RW, Fraumeni JF Jr (eds) Genetics of human cancer. Raven, New York, p 81Google Scholar
  14. Moorhead PS, Nowell PC, Mellman WJ, Battips DM, Hungerford DA (1960) Chromosome preparations of leukocytes cultures from human peripheral blood. Exp Cell Res 20: 613–616PubMedCrossRefGoogle Scholar
  15. Nowell PC, Hungerford DA (1960) A minute chromosome in human chronic granulocytic leukemia. Science 132: 1487CrossRefGoogle Scholar
  16. Paris Conference (1971) Standardization in human cytogenetics. Birth Defects: Original Article Series VIII 7 1972. The National Foundation, New YorkGoogle Scholar
  17. Pathak S, Strong LC, Ferrell RE, Trindade A (1982) Familial Renal Cell Carcinoma with a 3;11 chromosome translocation limited to tumor cells. Science 217: 939–941PubMedCrossRefGoogle Scholar
  18. Rowley JD (1983) Human oncogene locations and chromosome aberrations. Nature 301: 290–291PubMedCrossRefGoogle Scholar
  19. Rowley JD, Golomb HM, Vardiman J, Fukuhara S, Dougherty C, Potter D (1977) Further evidence for a non-random chromosomal abnormality in acute progranulocytic leukemia. Int J Cancer 20: 869–872PubMedCrossRefGoogle Scholar
  20. Seabright M (1971) A rapid bainding technique for human chromosomes. Lancet 11: 971–972CrossRefGoogle Scholar
  21. Shimosato Y, Kameya T, Hirohashi F (1979) Growth, morphology, and function of xenotrans planted human tumors. In: Sommers SC, Rosen PT (eds) Pathology annual, part 2. Appleton, New York, pp 215–257Google Scholar
  22. Tjio JH, Whang J (1962) Chromosome preparations of bone marrow cells without prior in vitro culture or in vivo colchicine administration. Stain Technol 37: 17–20PubMedGoogle Scholar
  23. Trent JM, Rosenfeld SB, Meyskens FL (1983) Chromosome 6q involvement in human malignant melanoma. Cancer Genet Cytogenet 9: 177–180PubMedCrossRefGoogle Scholar
  24. Whang-Peng J, Bunn PA, Kao-Shan CS, Lee EC, Carney DN, Gazdar A, Minna JD (1982) A nonrandom chromosomal abnormality, del 3p(14–23), in human small lung cancer. Cancer Genet Cytogenet 6: 119–134PubMedCrossRefGoogle Scholar
  25. Whang-Peng J, Carney DN, Lee EC, Kao-Shan CS, Bunn PA, Gazdar A, Minna JD (1983) In: Crispin R (ed) Cancer: etiology and prevention. Elsevier, New York, pp 47–60Google Scholar
  26. Wurster-Hill DH, Mauruer LH (1978) Cytogenetic diagnosis of cancer: Abnormalities of chromosomes and polyploid levels in the bone marrow of patients with small cell anaplastic carcinoma of lung. J Natl Cancer Inst 61: 1065–1075PubMedGoogle Scholar
  27. Yunis JJ, Ramsey N (1978) Retinoblastoma and subband deletion of chromosome 13. Am J Dis Child 132: 161–163PubMedGoogle Scholar
  28. Yunis JJ, Oken MM, Kaplan ME, Ensrud KM, Howe RR, Theologides A (1982) Distinctive chromosomal abnormalities in histologic subtypes of Non-hodgkin’s lymphoma. N Engl J Med 307: 1231–1236PubMedCrossRefGoogle Scholar
  29. Zech L, Haglund U, Nilsson K, Klein G (1976) Characteristic chromosomal abnormalities in biopsies and lymphoid cell lines from patients with Burkitt and non-Burkitt lymphomas. Int J Cancer 17: 47–56PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1985

Authors and Affiliations

  • J. Whang-Peng
    • 1
  • E. C. Lee
    • 1
  1. 1.Cytogenetic Oncology Section, MB, COP, DCT, NCINational Institutes of HealthBethesdaUSA

Personalised recommendations