Abstract
With regard to morphology, biology, and therapy it seems justified to consider small cell lung carcinoma (SCLC) separately from the other main forms of lung carcinoma (squamous cell, adenocarcinoma, large cell). This is expressed by the rough division of lung cancers into the small cell and non-small-cell groups. Regarding etiology, however, a separation of small cell carcinoma from the other types seems not to be justifiable and extremely difficult. Kreyberg (1962) has already combined squamous cell and small cell carcinomas into “group I tumors,” pointing out that these types have common causative factors, especially environmental carcinogens, including tobacco smoking, occupational hazards, and ionizing radiation. In recent years the “unitarian” theory of the origin of lung cancers, suggesting a common stem cell, has been revived and is replacing the theory of a separate histogenesis of SCLC from the neural crest. Biochemical investigations have revealed that the l-dopa decarboxylase, the key enzyme of the so-called APUD tumors (Pearse 1969), can be detected not only in SCLC but, though at lower levels, in any morphological type of lung cancer (Baylin and Gazdar 1981). Both in lung cancer cultures and in patients (at relapse) a morphological conversion from SCLC to non-SCLC histology has been observed (Gazdar et al. 1981; Fer et al. 1983). It is therefore not surprising that most lung carcinogens are associated with more or less the entire spectrum of lung cancer types in man.
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References
Abe S, Ohsaki Y, Kimura K, Tsuneta Y, Mikami H, Murao M (1982) Chromate lung cancer with special reference to its cell type and relation to the manufacturing process. Cancer 49: 783–787
Annegers JF, Carr DT, Woolner LB, Kurland LT (1978) Incidence trend and outcome of bronchogenic carcinoma in Olmsted County, Minnesota, 1935–1974. Mayo Clin Proc 53: 432–436
Archer VE, Saccomanno G. Jones JH (1974) Frequency of different histologic types of bronchogenic carcinoma as related to radiation exposure. Cancer 34: 2056–2060
Archer VE, Gillam JD, Wagoner JK (1976) Respiratory disease mortality among uranium miners. Ann NY Acad Sci 271: 280–293
Auerbach O, Garfinkel L, Parks VR (1975) Histologic type of lung cancer in relation to smoking habits, year of diagnosis and sites of metastases. Chest 67: 382–387
Auerbach O, Stout AP, Hammond EC, Garfinkel L (1961) Changes in bronchial epithelium in
relation to cigarette smoking and in relation to lung cancer. N Engl J Med 265:253–267 Auerbach O, Stout AP, Hammond EC, Garfinkel L (1962) Bronchial epithelium in former smokers. N Engl J Med 267: 119–125
Auerbach O, Garfinkel L, Parks VR (1979) Scar cancer of the lung. Cancer 43: 636–642 Axelson O, Dahigren E, Jansson CD, Rehnlund SO (1978) Arsenic exposure and mortality: a case-referent study from a Swedish copper smelter. Br J Ind Med 35: 8–15
Baylin SB, Gazdar AF (1981) Endocrine biochemistry in the spectrum of human lung cancer: Implications for the cellular origin of small cell carcinoma. In: Greco FA, Oldham RK, Bunn PA Jr (eds) Small cell lung cancer. Grune and Stratton, New York, pp 123–143
Beamis JF Jr. Stein A, Andrews JL Jr (1975) Changing epidemiology of lung cancer. Med Clin North Ani 59:315-325
Berge T, Toremalm NG (1975) Bronchial cancer — a clinical and pathological study. Scand J Respir Dis 56: 120–126
Blair WH (1974) Chemical induction of lung carcinomas in rats. In: Karbe E, Park JF (eds) Experimental lung cancer, carcinogenesis and bioassays. Springer, Berlin Heidelberg New York, pp 199–206
Burbank F (1972) U.S. lung cancer death rates begin to rise proportionately more rapidly for females than for males: a dose-response effect? J Chronic Dis 25: 473–479
Chan WC, Colbourne MJ, Fung SC, Ho HC (1979) Bronchial cancer in Hong Kong 1976–1977. Br J Cancer 39: 182–192
Court Brown WM, Doll R (1965) Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis. Br Med J 11: 1327–1332
Doll R (1955) Mortality from lung cancer in asbestos workers. Br J Ind Med 12: 81–86
Eck H, Haupt R, Rothe G (1969) Die gut-und bösartigen Lungengeschwülste. In: Uehlinger E (ed) Atmungswege und Lungen. Springer, Berlin Heidelberg New York (Handbuch der speziellen pathologischen Anatomie und Histologie, vol 3/4)
Eckert M, Hammann J, Höhn D, Schultess F (1979) Bronchialkarzinom. Diagnostik, Therapie und Ergebnisse. Fortschr Med 97: 1047–1050
Fer MF, Grosh WW, Greco FA (1983) Morphologic changes in small cell lung cancer. In: Greco FA (ed) Biology and management of lung cancer. Martinus Nijhoff, Boston, pp 109–124
Figueroa WG, Raszkowski R, Weiss W (1973) Lung cancer in chloromethyl methyl ether workers. N Engl J Med 288: 1096–1097
Frank AL (1978) Occupational cancer. In: Harris CC (ed) Pathogenesis and therapy of lung cancer. Marcel Dekker, New York Basel, pp 25–51
Gazdar AF, Carney DN, Guccion JG, Baylin SB (1981) Small cell carcinoma of the lung: Cellular origin and relationship to other pulmonary tumors. In: Greco FA, Oldham RK, Bunn PA Jr (eds) Small cell lung cancer. Grune and Stratton, New York, pp 145–175
Greco FA, Oldham RK, Bunn PA Jr (eds) (1981) Small cell lung cancer. Grune and Stratton, New York
Hammond EC, Selikoff IJ, Seidman H (1979) Asbestos exposure, cigarette smoking and death rates. Ann NY Acad Sci 330: 473–490
Harris CC (ed) (1978) Pathogenesis and therapy of lung cancer. Marcel Dekker, New York
Hermanek P, Gall FP (1979) Lungentumoren. Gerhard Witzstrock, Baden-Baden
Horâcek J, Plaèek V, Sevc J (1977) Histologic types of bronchogenic cancer in relation to different conditions of radiation exposure. Cancer 40: 832–835
Ishimaru T, Cihak RW, Land CE, Steer A, Yamada A (1975) Lung cancer at autopsy in A-bomb survivors and controls, Hiroshima and Nagasaki 1961–1970. Cancer 36: 1723–1728
Kannerstein M, Churg J (1972) Pathology of carcinoma of the lung associated with asbestos exposure. Cancer 30: 14–21
Karbe E, Park JF (eds) (1974) Experimental lung cancer, carcinogenesis and bioassays. Springer, Berlin Heidelberg New York
Katlic M, Carter D (1979) Prognostic implication of histology, size, and location of primary tumors. In: Muggia FM, Rozencweig M (eds) Lung cancer: progress in therapeutic research. Raven, New York, pp 143–150
Kennedy A (1972) Lung cancer in young adults. Br J Dis Chest 66: 147–154
Kreyberg L (1962) Histological lung cancer types: A morphological and biological correlation. Norwegian Universities Press, Oslo
Kreyberg L (1969) Aetiology of lung cancer: A morphological epidemiological and experimental analysis. Universitetsforlaget, Oslo
Kreyberg L (1978) Lung cancer in workers in a nickel refinery. Br J Ind Med 35: 109–116
Kreyberg L, Saxén E (1961) A comparison of lung tumor types in Finland and Norway. Br J Cancer 15: 211–214
Kuschner M, Laskin S, Drew RT, Cappiello V, Nelson N (1975) Inhalation carcinogenicity of alpha halo ethers. Arch Environ Health 30: 73–77
Lernen RA, Johnson WM, Wagoner JK, Archer VE, Saccomanno G (1976a) Cytologic observations and cancer incidence following exposure to BCME. Ann NY Acad Sci 271: 72–80
Lernen RA, Lee JS, Wagoner JK, Blejer HP (1976b) Cancer mortality among cadmium production workers. Ann NY Acad Sci 271: 273–279
Lemon FR, Walden RT (1966) Death from respiratory system disease among Seventh-Day Adventist Men. JAMA 198: 117–126
Lüders CJ, Themel KG (1954) Die Narbenkrebse der Lungen als Beitrag zur Pathogenese des peripheren Lungencarcinoms. Virchows Arch [Pathol Anat] 325: 499–551
Martell EA (1975) Tobacco radioactivity and cancer in smokers. Am Sci 63: 404–412
Nettesheim P, Hanna MG Jr, Deatherage JW Jr (eds) (1970) Morphology of experimental respiratory carcinogenesis. US Atomic Energy Commission (AEC Symposium Series 21 )
O’Berg MT (1980) Epidemiologic study of workers exposed to acrylonitrile. J Occup Med 22: 245–252
Pearse AGE (1969) The cytochemistry and ultrastructure of polypeptide hormone producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17: 303–313
Pedersen E, Hogetveit AC, Andersen A (1973) Cancer of respiratory organs among workers at a nickel refinery in Norway. Int J Cancer 12: 32–41
Putnam JS (1977) Lung carcinoma in young adults. JAMA 238: 35–36
Radford EP Jr, Hunt VR (1964) Polonium-210: A volatile radioelement in cigarettes. Science 143: 247–249
Selikoff IJ, Hammond EC, Churg J (1968) Asbestos exposure, smoking and neoplasia. JAMA 204: 104–110
Selikoff IJ, Seidman H, Hammond EC (1980) Mortality effects of cigarette smoking among Amosite asbestos factory workers. JNCI 65: 507–513
Stayner LT, Wegman DH (1982) Smoking, occupation, and histopathology of lung cancer: A case-control study with the use of the 3rd national cancer survey. JNCI 70: 421–426
Thiess AM, Hey W, Zeller H (1973) Zur Toxikologie von Dichlordimethyläther-Verdacht auf kanzerogene Wirkung auch beim Menschen. Zentralbi Arbeitsmed Arbeitsschutz Prophyl Ergonomie 23: 97–102
Vincent RG, Pickren JW, Lane WW, Bross I, Takita H, Houten L, Gutierrez AC, Rzepka T (1977) The changing histopathology of lung cancer. Cancer 39: 1647–1655
Wagner JC, Gilson JC, Berry G, Timbrell V (1971) Epidemiology of asbestos cancers. Br Med Bull 27: 71–76
Waxweiler RJ, Stringer W, Wagoner JK, Jones J (1976) Neoplastic risk among workers exposed to vinyl chloride. Ann NY Acad Sci 271: 40–48
Weiss W (1973) Cigarette smoke as a carcinogen. Am Rev Respir Dis 108: 364–366
Weiss W (1980) The cigarette factor in lung cancer due to chloromethyl ethers. J’Occup Med 22: 527–529
Weiss W (1981) Small cell carcinoma of the lung: Epidemiology and etiology. In: Greco FA, Oldham RK, Bunn PA Jr (eds) Small cell lung cancer. Grune and Stratton, New York, pp 1–34
Weiss W, Boucot KR, Seidman H, Carnahan WJ (1972) Risk of lung cancer according to histologic type and cigarette dosage. JAMA 222: 799–801
Weiss W, Moser RL, Auerbach O (1979) Lung cancer in chloromethyl ether workers. Am Rev Respir Dis 120: 1031–1037
Whitwell F, Newhouse ML, Bennett DR (1974) A study of the histological cell types of lung cancer in workers suffering from asbestosis in the United Kingdom. Br J Ind Med 31: 298–303
Wicks MJ, Archer VE, Auerbach O, Kuschner M (1981) Arsenic exposure in a copper smelter as related to histological type of lung cancer. Am J Ind Med 2: 25–31
Wynder EL, Hecht S (eds.) (1976) Lung cancer, UICC. UICC, Geneva (Technical report series, vol 25 )
Yesner R, Gellman NA, Feinstein AR (1973) A reappraisal of histopathology in lung cancer and correlation of cell types with antecedent cigarette smoking. Am Rev Respir Dis 107: 790–797
Zeller WJ, Schmähl D (1985) Ätiologie des Bronchialkarzinoms. In: Trendelenburg F (ed) Neoplasmen der Bronchien und der Lunge. Springer, Berlin Heidelberg New York (Handbuch der inneren Medizin, vol 4/4)
Zeller WJ, Schmähl D, Ivankovic S (1985) Inhalationsexperimente an Syrischen Goldhamstern: Kombination von chronischer Zigarettenrauchinhalation und intratrachealer Instillation von Benzo(a)pyren; Detoxifizierung des Zigarettenrauches durch Kohlefilter. Prax Klin Pneumol (in press)
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Zeller, W.J., Schmähl, D. (1985). Etiology of Small Cell Lung Carcinoma. In: Seeber, S. (eds) Small Cell Lung Cancer. Recent Results in Cancer Research, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82372-5_1
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