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Contribution of Prognostic Factors to Adjuvant Chemotherapy in Breast Cancer

  • Chapter
Adjuvant Chemotherapy of Breast Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 96))

Abstract

The prognostic factors in women with primary breast cancer are numerous [32]. In most reports published over the past 20 years they were assessed on retrospective evaluation of series whose staging, treatment and follow-up were often not homogeneous. However, in recent years prospective randomized clinical trials undertaken in patients with resectable breast cancer provided the opportunity to reassess the adequacy of given prognostic subgroups. In particular, through the analysis of large case series, the National Surgical Adjuvant Breast Project (NSABP) has contributed more than any other research group in systematically assessing and comparing the value of different prognostic variables [12–18].

Supported in part by Contract N01-CM-07338 with the Division of Cancer Treatment, National Cancer Institute, National Institutes of Health

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References

  1. Andersen JA, Mattheiem WH (1983) Markers and prognostic factors in breast cancer disease. Workshop report. Eur J Cancer Clin Oncol 19: 1699–1707

    Article  Google Scholar 

  2. Attiyeh FF, Jensen M, Huvos AG, Fracchia A (1977) Axillary micrometastases and macrometastases in carcinoma of the breast. Surg Gynecol Obstet 144: 839–842

    PubMed  CAS  Google Scholar 

  3. Bauer TW, O’Ceallaigh D, Eggleston JC, Moore GW, Baker RR (1983) Prognostic factors in patients with stage I, estrogen receptor-negative carcinoma of the breast. A clinicopathologic study. Cancer 52: 1423–1431

    CAS  Google Scholar 

  4. Bertuzzi A, Vezzoni P, Ronchi E (1981) Prognostic importance of progesterone receptors alone or in combination with estrogen receptors in node negative breast cancer ( Abstr ). Proc Am Soc Clin Oncol 22: 447

    Google Scholar 

  5. Bettelheim R, Neville AM (1981) Lymphatic and vascular channel involvement within infiltrative breast carcinomas as a guide to prognosis at the time of primary surgical treatment. Lancet 2: 631

    Article  PubMed  CAS  Google Scholar 

  6. Bonadonna G, Valagussa P (1983) Chemotherapy of breast cancer: current views and results. Int J Radiat Oncol Biol Phys 9: 279–297

    PubMed  CAS  Google Scholar 

  7. Bonadonna G, Valagussa P (to be published) Adjuvant systemic therapy for resectable breast cancer

    Google Scholar 

  8. Buckman R, Coombes RC, Dearnaley DP, Gore M, Gusterson B, Neville AM (to be published) Some clinical uses of biological markers. In: Bonadonna G (ed) Breast cancer: diagnosis and management. Wiley, London

    Google Scholar 

  9. Buzdar A, Smith T, Blumenschein G, Hortobagyi G, Hersh E, Gehan E (1981) Adjuvant chemotherapy with fluorouracil, doxorubicin, and cyclophosphamide (FAC) for stage II or III breast cancer: 5-year results. In: Salmon SE, Jones SE (eds) Adjuvant therapy of cancer III. Grune and Stratton, New York, pp 419–426

    Google Scholar 

  10. Clark GM, McGuire WL, Hubay CA, Pearson OH, Marshall JS (1983) Progesterone receptor as a prognostic factor in Stage II breast cancer. N Engl J Med 309: 1343–1347

    Article  PubMed  CAS  Google Scholar 

  11. Colnaghi MI, Buraggi GL, Ghione M (eds) (1982) Markers for diagnosis and monitoring of human cancer. Academic, London (Proceedings of the Serono symposia, no 46 )

    Google Scholar 

  12. Fisher B, Bauer M, Wickerham DL, Redmond CK, Fisher ER, Cruz AB, Foster R, Gardner B, Lerner H, Margolese R, Poisson R, Shibata H, Volk H et al. (1983) Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update. Cancer 52: 1551–1557

    Article  PubMed  CAS  Google Scholar 

  13. Fisher B, Redmond CK, Wickerham L, Rockette HE, Brown A, Allegra J, Bowman D, Plotkin D, Wolter J et al. (1983) Relation of estrogen and/or progesterone receptor content of breast cancer to patient outcome following adjuvant chemotherapy. Breast Cancer Res Treat 3: 355–364

    Article  PubMed  CAS  Google Scholar 

  14. Fisher B, Slack NH, Bross IDJ (1969) Cancer of the breast: size of neoplasm and prognosis. Cancer 24: 1071–1080

    Article  PubMed  CAS  Google Scholar 

  15. Fisher ER, Gregorio RM, Fisher B (1975) The pathology of invasive breast cancer. A syllabus derived from findings of the National Surgical Adjuvant Breast Project (protocol no 4). Cancer 36: 1–85

    Article  PubMed  CAS  Google Scholar 

  16. Fisher ER, Osborne CK, McGuire WL, Redmond C, Knight WA III, Fisher B, Bannayan G, Walder A, Gregory EJ, Jacobsen A, Queen DM, Bennet DE, Ford HC (1981) Correlation of primary breast cancer histopathology and estrogen receptor content. Breast Cancer Res Treat 1: 37–41

    Article  PubMed  CAS  Google Scholar 

  17. Fisher ER, Palekar AS, Rockette H, Redmond C, Fisher B (1978) Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no 4). V. Significance of axillary nodal micro-and macrometastases. Cancer 42: 2032–2038

    Article  PubMed  CAS  Google Scholar 

  18. Fisher ER, Redmond C, Fisher B (1980) Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no 4). VI. Discriminants for five-year treatment failure. Cancer 46: 908–918

    Article  PubMed  CAS  Google Scholar 

  19. Fracchia AA, Rosen PP, Ashikari R (1980) Primary carcinoma of the breast without axillary lymph node metastases. Surg Gynecol Obstet 151: 375–378

    PubMed  CAS  Google Scholar 

  20. Gentili C, Sanfilippo O, Silvestrini R (1981) Cell proliferation and its relationship to clinical features and relapse in breast cancer. Cancer 48: 974–979

    Article  PubMed  CAS  Google Scholar 

  21. Gest J, Brunet M, Hebert H, Pallud C, Tubiana M (1982) Prognostic significance of axillary micro and macrometastasis in breast cancer (T1 and T2). Preliminary results. Int J Breast Mammary Pathol Senologia 1: 49–52

    Google Scholar 

  22. Huvos AG, Hutter RVP, Berg JW (1971) Significance of axillary macrometastases and micrometastases in mammary cancer. Ann Surg 173: 44–46

    Article  PubMed  CAS  Google Scholar 

  23. Mansour EG, Hastert M, Park CH, Koehler KA, Petrelli M (1983) Tissue and plasma carcinoembryonic antigen in early breast cancer. A prognostic factor. Cancer 51: 1243–1248

    Article  PubMed  CAS  Google Scholar 

  24. Merlin C, Gloor F, Hardmeier T, Senn HJ (1980) Hat die intramammäre Lymphangiosis carcinomatosa beim nodal-negativen Mammakarzinom eine prognostische Bedeutung? Schweiz Med Wochenschr 110: 605–609

    PubMed  CAS  Google Scholar 

  25. Nime FA, Rosen PP, Thaler HT, Ashikari R, Urban JA (1977) Prognostic significance of tumor emboli in intramammary lymphatics in patients with mammary carcinoma. Am J Surg Pathol 1: 25–30

    Article  PubMed  CAS  Google Scholar 

  26. Redding WH, Coombes RC, Monaghan P, Clink HM, Imrie SF, Dearnaley DP, Ormerod MG, Sloane JP, Gozet JC, Powles TJ, Neville AM (1983) Detection of micrometastases in patients with primary breast cancer. Lancet 2: 1271–1273

    Article  PubMed  CAS  Google Scholar 

  27. Rilke F (to be published) Influence of pathologic factors on management. In: Bonadonna G (ed) Breast cancer: diagnosis and management. Wiley, London

    Google Scholar 

  28. Rolf Smith S. Howell A, Minawa A, Morrison JM (1982) The clinical value of immunohistochemically demonstrable CEA in breast cancer: a possible method of selecting patients for adjuvant chemotherapy. Br J Cancer 46: 757–764

    Article  Google Scholar 

  29. Rosen PP, Saigo PE, Braun DW, Weathers E, De Palo A (1981) Precitors of recurrence in stage I ( TINOMO) breast carcinoma. Ann Surg 193: 15–25

    Article  PubMed  CAS  Google Scholar 

  30. Rosen PP, Saigo PE, Braun DW, Weathers E, Fracchia AA, Kinne DW (1981) Axillary micro-and macrometastases in breast cancer. Prognostic significance of tumor size. Ann Surg 194: 585–591

    Article  PubMed  CAS  Google Scholar 

  31. Saez S, Cheix F, Asselain B (1983) Prognostic value of estrogen and progesterone receptors in primary breast cancer. Breast Cancer Res Treat 3: 345–354

    Article  PubMed  CAS  Google Scholar 

  32. Stewart JF, Rubens RD (to be published) General prognostic factors. In: Bonadonna G (ed) Breast cancer: diagnosis and management. Wiley, London

    Google Scholar 

  33. Stewart JF, Rubens RD, Millis RR, King RJ, Hayward IL (1983) Steroid receptors and prognosis in operable (stage I and II) breast cancer. Eur J Cancer Clin Oncol 19: 1381–1387

    Article  PubMed  CAS  Google Scholar 

  34. Valagussa P, Bonadonna G. Veronesi U (1978) Patterns of relapse and survival following radical mastectomy. Analysis of 716 consecutive patients. Cancer 41: 1171–1178

    Google Scholar 

  35. Veronesi U, Saccozzi R, Del Vecchio M, Banfi A, Clemente C, De Lena M, Gallus G, Greco M, Luini A, Marubini E, Muscolino G, Rilke F, Salvadori B, Zecchini A, Zucali R (1981) Comparing radical mastectomy with quadrantectomy, axillary dissection and radiotherapy in patients with small cancer of the breast. N Engl J Med 305: 6–11

    Article  PubMed  CAS  Google Scholar 

  36. Weigand RA, Isenberg WM, Russo J, Brennan MJ, Rich MA, and Breast Cancer Prognostic Study Associates (1982) Blood vessel invasion and axillary lymph node involvement as prognostic indicators for human breast cancer. Cancer 50: 962–969

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133, Milano, Italy

    G. Bonadonna & P. Valagussa

Authors
  1. G. Bonadonna
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  2. P. Valagussa
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Editors and Affiliations

  1. Medizinische Klinik C, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland

    Hans-Jörg Senn

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© 1984 Springer-Verlag Berlin · Heidelberg

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Bonadonna, G., Valagussa, P. (1984). Contribution of Prognostic Factors to Adjuvant Chemotherapy in Breast Cancer. In: Senn, HJ. (eds) Adjuvant Chemotherapy of Breast Cancer. Recent Results in Cancer Research, vol 96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82357-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-82357-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82359-6

  • Online ISBN: 978-3-642-82357-2

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