Abstract
The relatively slow and limited regression of solid tumor masses following and during chemotherapy initially led many to believe, because of the long duration of treatment implied to be necessary by these slow regressions, that chemotherapeutic cure of a solid tumor was impractical if not impossible. However, with the later realization that solid tumor mass reduction grossly underestimates the fraction of a tumor cell population killed by chemotherapy [6], it became evident that chemotherapy may be more effective than had been anticipated. Furthermore, it has been well documented that curability is inversely proportional to the size of the tumor cell population [4]. Thus, it was anticipated that tumor debulking followed by chemotherapy, aimed at destruction of surviving tumor stem cells, would lead to cure for a significant fraction of appropriately staged breast cancer patients. The first clinical trials, however, were disappointing [3].
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References
Bonadonna G, Gasparini M, Rossi A (1980) Adjuvant therapies of postsurgical minimal residual disease. In: Mathe G, Muggia FM (eds) Cancer chemo-and immunopharmacology. 1. Chemopharmacology. Springer, Berlin Heidelberg New York, pp 8–25 (Recent results in cancer research, vol 74 )
Cortes EP, Holland JF, Wang JJ, Sinks LF, Blom J, Senn H, Bank A, Glidewell 0 (1974) Amputation and adriamycin in primary osteosarcoma. N Engl J Med 291: 998–1000
Fisher B, Ravdin RG, Ausman AK, Slack NH, Moore GE, Noer RF (1968) Surgical adjuvant chemotherapy in cancer of the breast: Results of a decade of cooperative investigation. Ann Surg 168: 337–356
Griswold DP Jr (1975) The potential for murine tumor models in surgical adjuvant chemotherapy. Cancer Chemother Rep 5: 187–204
Griswold DP Jr, Schabel FM Jr, Corbett TH, Dykes DJ (1981) Concepts for controlling drug-resistant tumor cells. In: Fidler IJ, White RJ (eds) Design of models for testing cancer therapeutic agents. Van Nostrand Reinhold, New York, pp 215–224
Griswold DP Jr, Schabel FM Jr, Wilcox WS, Simpson-Herren L, Skipper HE (1968) Success and failure in the treatment of solid tumors. I. Effects of cyclophosphamide (NSC-26271) on primary and metastatic plasmacytoma in the hamster. Cancer Chemother Rep 52: 345–387
Jaffe N, Frei E III, Traggis D, Bishop Y (1974) Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. N Engl J Med 291: 994–997
Levitt SH (1983) Pattern of failure in breast cancer. Cancer Treat Symp 2: 123–129
Martin DS (1981) The scientific basis for adjuvant chemotherapy. Cancer Treat Rev 8: 169–189
Mayo JG, Laster WR Jr, Andrews CM, Schabel FM Jr (1972) Success and failure in the treatment of solid tumors. III. “Cure” of metastatic Lewis lung carcinoma with methyl-CCNU (NSC-95441) and surgery-chemotherapy. Cancer Chemother Rep 56: 183–195
Schabel FM Jr, Griswold DP Jr, Corbett TH, Laster WR Jr (1983) Increasing therapeutic response rates to anticancer drugs by applying the basic principles of pharmacology. Pharmacol Ther 20: 283–305
Schabel FM Jr, Simpson-Herren L (1978) Some variables in experimental tumor systems which complicate interpretation of data from in vivo kinetic and pharmacologic studies with anticancer drugs. In: Schabel FM Jr (ed) Fundamentals in cancer chemotherapy. Karger, Basel, Antibiotics and chemotherapy, vol 23, pp 113–129
Shapiro DM, Fugmann RA (1957) A role for chemotherapy as an adjuvant to surgery. Cancer Res 17: 1098–1101
Skipper HE, Schabel FM Jr (1984) Tumor cell heterogeneity: Implications with respect to classification of cancers by chemotherapeutic effect. Cancer Treat Rep 68: 43–61
Smith IE (1983) Adjuvant chemotherapy for early breast cancer. Br Med J 287: 379–380
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© 1984 Springer-Verlag Berlin · Heidelberg
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Griswold, D.P., Laster, W.R., Trader, M.W., Dykes, D.J. (1984). The Preclinical Scientific Basis for Adjuvant Chemotherapy in Breast Cancer. In: Senn, HJ. (eds) Adjuvant Chemotherapy of Breast Cancer. Recent Results in Cancer Research, vol 96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82357-2_1
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DOI: https://doi.org/10.1007/978-3-642-82357-2_1
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