Significance of Drug Dose, Timing and Radiotherapy in Adjuvant Therapy of Breast Cancer
In the past decade, many adjuvant chemotherapy trials in operable breast cancer have been conducted. The results of these trials have answered a number of questions, but have also raised new issues. Among other issues, results have suggested that relapse-free survival was dependent on the dose of cytotoxic drugs and the timing of initiation of chemotherapy [1, 2]. Routine postoperative irradiation was shown to have a detrimental effect on the efficacy of adjuvant chemotherapy [2, 3]. At M.D. Anderson Hospital, since 1974, a combination of fluorouracil, doxorubicin (adriamycin), and cyclophosphamide (FAC) has been utilized following regional therapy in patients with operable breast cancer. In this paper the dose of cytotoxic drugs, timing of initiation of chemotherapy, and the role of routine postoperative irradiation are evaluated.
KeywordsBacillus Doxorubicin Methotrexate Cyclophosphamide Fluorouracil
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