Abstract
Osteosarcomas are relatively rare tumors affecting younger people, mostly men. The prognosis in these cases is uniformly bad. An analysis of the course of the disease 10 years ago revealed that roughly 10 months after removal of the primary tumor, lung metastases develop (Sweetnam et al. 1971). Before 1970, a 5-year survival of 20% or less is reported following surgical treatment of the bone tumor. Chemotherapy was essentially unsuccesful until the early 1970s, when trials with doxorubicin and high-dose methotrexate were initiated. With these two drugs, considerable response rates (mostly partial remissions) were reported in metastatic disease.
This study was supported in part by grants from Emdo foundation (Zürich, Switzerland) and from Cyanamid Inc. (New York). The authors are indebted to Mrs. M. Balzer, Mrs. C. Bommes, Mrs. M. Erni, and Mrs. U. Früh for excellent technical assistance and to Mrs. K. Lustig for animal care. We are grateful to Mrs. R. Fringeli for typing the manuscript
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© 1984 Springer-Verlag Berlin · Heidelberg
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Honegger, HP., von Hochstetter, A., Groscurth, P., Hofmann, V., Cserhati, M. (1984). The Effect of Chemotherapy on Human Bone Sarcomas: A Clinical and Experimental Study. In: Hofmann, V., Berens, M.E., Martz, G. (eds) Predictive Drug Testing on Human Tumor Cells. Recent Results in Cancer Research, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82295-7_8
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DOI: https://doi.org/10.1007/978-3-642-82295-7_8
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