Evaluation of Schedule Dependency of Anticancer Drugs in the Human Tumor Clonogenic Assay

  • R. Ludwig
  • D. S. Alberts
  • S. E. Salmon
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 94)

Abstract

The cytotoxicity of anticancer drugs may depend on the schedule of administration as well as on the dose used. There are limited data concerning the evaluation of drug schedules using human tumor models. The purpose of our study was to evaluate schedule dependency of anticancer drugs by comparing 1-h to continuous drug exposures in the human tumor clonogenic assay (HTCA) (Salmon et al. 1978).

Keywords

Doxorubicin Myeloma Etoposide Bleomycin Vinblastine 

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References

  1. Salmon SE, Hamburger AW, Soehnlen B, Durie BGM, Alberts DS, Moon TE (1978) Quantitation of differential sensitivity of human tumor stem cells to anticancer drugs. N Engl J Med 29: 1321–1327CrossRefGoogle Scholar
  2. Van Putten LM (1974) Are cell kinetic data relevant for the design of tumor chemotherapy schedules? Cell Tissue Kinet 7: 493–504PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • R. Ludwig
    • 1
  • D. S. Alberts
    • 1
  • S. E. Salmon
    • 1
  1. 1.Health Science Center, Section of Hematology and OncologyThe University of ArizonaTucsonUSA

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