Abstract
The cytotoxicity of anticancer drugs may depend on the schedule of administration as well as on the dose used. There are limited data concerning the evaluation of drug schedules using human tumor models. The purpose of our study was to evaluate schedule dependency of anticancer drugs by comparing 1-h to continuous drug exposures in the human tumor clonogenic assay (HTCA) (Salmon et al. 1978).
This work was supported in part by grants CA-17094, 21839, and 23074 from the National Institutes of Health, Bethesda, MD, USA
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References
Salmon SE, Hamburger AW, Soehnlen B, Durie BGM, Alberts DS, Moon TE (1978) Quantitation of differential sensitivity of human tumor stem cells to anticancer drugs. N Engl J Med 29: 1321–1327
Van Putten LM (1974) Are cell kinetic data relevant for the design of tumor chemotherapy schedules? Cell Tissue Kinet 7: 493–504
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© 1984 Springer-Verlag Berlin · Heidelberg
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Ludwig, R., Alberts, D.S., Salmon, S.E. (1984). Evaluation of Schedule Dependency of Anticancer Drugs in the Human Tumor Clonogenic Assay. In: Hofmann, V., Berens, M.E., Martz, G. (eds) Predictive Drug Testing on Human Tumor Cells. Recent Results in Cancer Research, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82295-7_21
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DOI: https://doi.org/10.1007/978-3-642-82295-7_21
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