Development of a Nucleotide Precursor Incorporation Assay for Testing Drug Sensitivity of Human Tumors
Experimental research carried out in the past few years has led to different kinds of in vitro assays for drug screening on human tumors at the preclinical level. At present, many different systems, newly developed or derived from the improvement of previous ones (Daidone et al. 1981; Group for sensitivity testing of tumors 1981; Salmon 1980; Sanfilippo et al. 1981; Von Hoff et al. 1981; Weisenthal et al. 1983), have proved to be specific enough and potentially useful in different fields of application. Some of these systems appear more suitable for basic studies of biochemical and genetic aspects of cellular sensitivity and of the relationship between activity and pharmacokinetics at the cellular level; others can be used for studies more directly related to clinical application, such as the screening of new drugs and of the more active drugs on different tumor types or on individual patients for a tailored therapy.
KeywordsLymphoma Melphalan Cyclophosphamide Etoposide Vincristine
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