Abstract
The early foundations of organic mass spectrometry evolved with the requirement and constraint that the sample or a suitable chemical derivative thereof be volatilized without thermal degradation prior to ionization and internal energy deposition into either the ambient ion source chamber vacuum or the injection port of a gas chromatograph/mass spectrometer, both usually held in the order of 200 + 50°. However, in this past decade, the inventions of new types of ion sources and techniques which obviate the requirement of sample volatilization prior to ionization per se have been occurring at a seemingly accelerating pace since the description of the first breakthrough in 1969 (viz., field desorption) and subsequently plasma desorption, laser desorption, secondary ion and thermospray techniques [1]. The steady successes, particularly using the techniques of field desorption and plasma desorption, have made sustained pioneering contributions in the characterization of previously intractable polar and labile biological substances and have set the stage for intimate mass spectrometric participation in studies of higher molecular weight biological and synthetic polymeric substances [2, 3]. Judging from the sometimes similar nature of the mass spectra observed, all of these new ionization/“desorption” techniques have attributes in common. However, their diversity (including their associated instruments’ ion optical properties, detectors, and computers) has quickly led to the ability to analyze directly the majority of compound types previously inaccessible by mass spectrometric techniques, including the polyfunctional polar, chemically and/or thermally labile biological substances, their salts, organometallic complexes, modified biopolymers, etc. [1, 2].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
For review, see K.L. Busch and R.G. Cooks: Science 218, 247 (1982).
For review, see A.L. Burlingame, A. Dell and D. Russell: Anal. Chem. 52, 363R (1982); A.L. Burlingame, J. Whitney and D. Russell: Anal. Chem., to be published April 1984.
R.D. Macfarlane: Anal. Chem. 55, 1247A (1983).
A. Benninghoven and W.K. Sichterman: Anal. Chem. 50, 1180 (1978).
H. Kambara and S. Hishida: Anal. Chem. 53, 2340 (1981).
R.G. Cooks and K.L. Busch: Int. J. Mass Spectrom. Ion Phys. 53, 111 (1983).
D.J. Surman and J.C. Vickerman: J. Chem. Res. (S), 170 (1981).
D.J. Surman and J.C. Yickerman: J. Chem. Soc. Chem. Commun., 324 (1981).
M. Barber, R.S. Bardoli, R.D. Sedgwick and A.N. Tyler: J. Chem. Soc. Chem. Commun., 325 (1981).
W. Aberth, K.M. Straub and A.L. Burlingame: Anal. Chem. 54, 2029 (1982).
W. Aberth and A.L. Burlingame: in “Ion Formation from Organic Solids”, A. Benninghoven, ed., Springer Series in Chemical Physics, Vol. 25, 1983, p. 167.
W. Aberth, R. Reginato and A.L. Burlingame: This conference.
A.L. Burlingame, W. Aberth, R. Reginato, F.C. Walls, J.O. Whitney and L. Taylor: Presented at 31st Annual Conference on Mass Spectrometry and Allied Topics, Boston, MA, 1982, Paper No. W0F4.
C.H.L. Shackleton, Y.R. Mattox and J.W. Honour: J. Steroid Biochem. 19, 209 (1983).
C.H.L. Shackleton: Clin. Chem. 29/2, 246 (1983).
J.O. Whitney, S. Lewis, K.M. Straub, M.M. Thaler and A.L. Burlingame: Proc. 6th Annual Meeting of Japanese Society for Medical Mass Spectrometry 6, 33 (1981).
J.O. Whitney and A.L. Burlingame: Proc. 7th Annual Meeting of Japanese Society for Medical Mass Spectrometry 7, 3 (1982).
J.O. Whitney, Y. Ling, D. Grunberger, M.M. Thaler and A.L. Burlingame: Proc. 8th Annual Meeting of Japanese Society for Medical Mass Spectrometry 8, 47 (1983).
I thank J. Baenziger for providing this sample.
A. Dell and C.E. Ballou: Biomed. Mass Spectrom. 10, 150 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Burlingame, A.L. (1984). Cesium Ion Liquid Matrix Secondary Ion Mass Spectrometry and Its Impact on the Characterization of Free Labile Biological Substances. In: Benninghoven, A., Okano, J., Shimizu, R., Werner, H.W. (eds) Secondary Ion Mass Spectrometry SIMS IV. Springer Series in Chemical Physics, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82256-8_104
Download citation
DOI: https://doi.org/10.1007/978-3-642-82256-8_104
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82258-2
Online ISBN: 978-3-642-82256-8
eBook Packages: Springer Book Archive