Leukemia pp 29-50 | Cite as

Cytogenetics in Leukemia: Implications for Pathogenesis and Prognosis

  • D. K. Hossfeld
  • H.-J. Weh
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 93)

Abstract

Since the first description of the chromosome constitution of leukemic cells by Ford et al. in 1958 [1], leukemia cytogenetics has become a valuable tool for both researchers and practicing physicians. It has revived the stem cell concept, contributed to our understanding of clonal evolution and progression, and climaxed recently in the localization of “cancer genes” on certain chromosome segments. For the physician, chromosome analysis of leukemic cells gained an important role in diagnosis and differential diagnosis, and also in the follow-up of patients with preleukemic and leukemic disorders; in addition, in a number of diseases chromosomal findings were shown to be an independent prognostic factor which should be considered in the planning of therapeutic strategies. In this article we will concentrate on what cytogenetics can tell us about the pathogenesis of leukemias, leukemogenesis, and the role of chromosomes in the prognosis of patients with leukemic conditions. Diagnostic chromosomal findings will be described only briefly in the context of the aforementioned topics.

Keywords

Europe Lymphoma Petroleum Tyrosine Leukemia 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • D. K. Hossfeld
    • 1
  • H.-J. Weh
    • 1
  1. 1.Abteilung für Onkologie und HämatologieMedizinische UniversitätsklinikHamburg 20Germany

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