Leukemia pp 29-50 | Cite as

Cytogenetics in Leukemia: Implications for Pathogenesis and Prognosis

  • D. K. Hossfeld
  • H.-J. Weh
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 93)


Since the first description of the chromosome constitution of leukemic cells by Ford et al. in 1958 [1], leukemia cytogenetics has become a valuable tool for both researchers and practicing physicians. It has revived the stem cell concept, contributed to our understanding of clonal evolution and progression, and climaxed recently in the localization of “cancer genes” on certain chromosome segments. For the physician, chromosome analysis of leukemic cells gained an important role in diagnosis and differential diagnosis, and also in the follow-up of patients with preleukemic and leukemic disorders; in addition, in a number of diseases chromosomal findings were shown to be an independent prognostic factor which should be considered in the planning of therapeutic strategies. In this article we will concentrate on what cytogenetics can tell us about the pathogenesis of leukemias, leukemogenesis, and the role of chromosomes in the prognosis of patients with leukemic conditions. Diagnostic chromosomal findings will be described only briefly in the context of the aforementioned topics.


Acute Lymphoblastic Leukemia Acute Leukemia Chronic Myelogenous Leukemia Acute Myelogenous Leukemia Acute Myelogenous Leukemia Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ford CE, Jacobs PA, Lajtha LG (1958) Human somatic chromosomes. Nature 181: 1565–1568PubMedCrossRefGoogle Scholar
  2. 2.
    Berger R, Bernheim A, Flandrin G (1980) Absence d’anomalie chromosomique et leucémie aiguë: Relation avec les cellules médullaires normales. C R Acad Sei [D] (Paris) 290: 1557–1559Google Scholar
  3. 3.
    Carbonell F, Grilli G, Fliedner TM (1981) Cytogenetic evidence for a clonal selection of leukemic cells in culture. Leuk Res 5: 395–398PubMedCrossRefGoogle Scholar
  4. 4.
    Knuutila S, Vuopio P, Elonen E, Siimes M, Kovanen R, Borgström GH, de la Chapelle A (1981) Culture of bone marrow reveals more cells with chromosomal abnormalities than the direct method in patients with hematologic disorders. Blood 58: 369–375Google Scholar
  5. 5.
    Yunis J J (1982) Comparative analysis of high-resolution chromosome technique for leukemic bone marrows. Cancer Genet Cytogenet 7: 43–50PubMedCrossRefGoogle Scholar
  6. 6.
    Weh HJ, von Paleske A, Hossfeld DK (to be published) Disappearance of hypotetraploid clones after short term culture of leukemic cells. A case report. Cancer Genet CytogenetGoogle Scholar
  7. 7.
    Pedersen-Bjergaard J, Vindelov L, Philip P, Ruutu P, Elmgreen J, Repo H, Christensen IJ, Killmann S-A, Jensen G (1982) Varying involvement of peripheral granulocytes in the clonal abnormality — 7 in bone marrow cells in preleukemia secondary to treatment of other malignant tumors: cytogenetic results compared with results of flow cytometric DNA analysis and neutrophil Chemotaxis. Blood 60: 172–179PubMedGoogle Scholar
  8. 8.
    Sonta SI, Sandberg AA (1977) Chromosomes and causation of human cancer and leukemia. XXVIII. Value of detailed chromosome studies on large numbers of cells in CML. Am J Hematol 3: 121–126PubMedGoogle Scholar
  9. 9.
    First International Workshop on Chromosomes in Leukemia (1978) Cancer Res 38: 867–868Google Scholar
  10. 10.
    ISCN (1978) An international system for human cytogenetic nomenclature, 1978. Birth defects: original article series, vol 14, no 8. The National Foundation, New YorkGoogle Scholar
  11. 11.
    Nowell PC, Hungerford DA (1960) A minute chromosome in human chronic granulocytic leukemia. Science 132: 1497Google Scholar
  12. 12.
    Rowley JD (1973) A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature 243: 290–293PubMedCrossRefGoogle Scholar
  13. 13.
    Wayne AW, Sharp JC (1982) A photometric study of the standard Philadelphia (Ph1) translocation of chronic myeloid leukemia ( CML ). Cancer Genet Cytogenet 5: 253–256PubMedCrossRefGoogle Scholar
  14. 14.
    De Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR (1982) A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature 300: 765–767PubMedCrossRefGoogle Scholar
  15. 15.
    Bartam CR, de Klein A, Hagemeier A, Agthoven T, van Kessel AG, Bootsma D, Grosveld G, Ferguson-Smith MA, Davies T, Stone M, Heisterkamp N, Stephenson JR, Groffen J (1983) Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukemia. Nature 306: 277–280CrossRefGoogle Scholar
  16. 16.
    Bishop JM (1982) Oncogenes. Sci Am 3: 69–78Google Scholar
  17. 17.
    Roozendaal KJ, van der Reijden HJ, Geraedts JPM (1981) Philadelphia chromosome positive acute lymphoblastic leukemia with T-cell characteristics. Br J Haematol 47: 145–147PubMedCrossRefGoogle Scholar
  18. 18.
    Dankbaar H, Willemze R, Spaander PJ, Geraedts JPM (1982) Philadelphia chromosome positive T-ALL. Br J Haematol 50: 543–546PubMedCrossRefGoogle Scholar
  19. 19.
    Hernandez P, Carhot J, Cruz C (1982) Chronic myeloid leukemia blast crisis with T-cell features. Br J Haematol 51: 175–180PubMedCrossRefGoogle Scholar
  20. 20.
    Greaves MF, Verbi W, Reeves R, Hoffbrand A, Drysdale HC, Jones L, Sacker LS, Samaratunga J (1979) “Pre-B” phenotypes in blast crisis of Ph1-positive CML: evidence for a pluripotential stem cell “target”. Leuk Res 3: 181–186PubMedCrossRefGoogle Scholar
  21. 21.
    LeBien TW, Hozier J, Minowada J, Kersey JH (1979) Origin of chronic myelocytic leukemia in a precursor of pre-B lymphocytes. N Engl J Med 301: 144–147PubMedCrossRefGoogle Scholar
  22. 22.
    Martin PJ, Majfeld V, Fialkow PJ (1982) B-lymphoid cell involvement in chronic myelogenous leukemia: implications for the pathogenesis of the disease. Cancer Genet Cytogenet 6: 359–368PubMedCrossRefGoogle Scholar
  23. 23.
    Bernheim A, Berger R, Preud’homme JL, Labaume S, Bussel A, Barot-Ciorbaru R (1981) Philadelphia chromosome positive blood B lymphocytes in chronic myelocytic leukemia. Leuk Res 5: 331–339PubMedCrossRefGoogle Scholar
  24. 24.
    Fialkow PJ, Jacobson RJ, Papayannopoulou T (1977) Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. Am J Med 63: 125–130PubMedCrossRefGoogle Scholar
  25. 25.
    Hossfeld DK (1975) Additional chromosomal indication for the unicellular origin of chronic myelocytic leukemia. Z Krebsforsch 83: 269–273CrossRefGoogle Scholar
  26. 26.
    Chaganti RSK, Bailey RB, Jhanwar SC, Arlin ZA, Clarkson BD (1982) Chronic myelogenous leukemia in the monosomic cell line of a fertile Turner syndrome mosaic (45, X/46, XX ). Cancer Genet Cytogenet 5: 215–221PubMedCrossRefGoogle Scholar
  27. 27.
    Hossfeld DK (1975) Chronic myelocytic leukemia: Cytogenetic findings and their relations to pathogenesis and clinic. Ser Haemat 8: 53–72Google Scholar
  28. 28.
    Singer JW, Pialkow PJ, Steinmann L, Najfeld V, Stein SJ, Robinson WA (1979) Chronic myelocytic leukemia (CML): Failure to detect residual normal committed stem cells in vitro. Blood 53: 264–268PubMedGoogle Scholar
  29. 29.
    Wayne AW, Sharp JC, Joyner MV, Sterndale H, Pulford KAF (1979) The significance of Ph1 mosaicism: A report of six cases of chronic granulocytic leukaemia and two cases of acute myeloid leukaemia. Br J. Haematol 43: 353–360PubMedCrossRefGoogle Scholar
  30. 30.
    Carbonell E, Benitez J, Prieto F, Badia L, Sánchez-Payos J (1982) Chromosome banding patterns in patients with chronic myelocytic leukemia. Cancer Genet Cytogenet 7: 287–297PubMedCrossRefGoogle Scholar
  31. 31.
    Cunningham I, Gee T, Dowling M, Chaganti R, Bailey R, Hopfan S, Bowden L, Turnbull A, Knapper W, Clarkson B (1979) Results of treatment of Ph1 — chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol). Blood 53: 375–395PubMedGoogle Scholar
  32. 32.
    Sharp JC, Joyner MV, Wayne AW, Kemp J, Crofts M, Birch A, McArthur G, Lai S, Sterndale H, Williams Y (1979) Karyotypic conversion in Ph1-positive CML with combination chemotherapy. Lancet 1: 1370–1372PubMedCrossRefGoogle Scholar
  33. 33.
    Singer JW, Clarkson BD, Fialkow PJ (1980) Restoration of nonclonal hematopoiesis in chronic myelogenous leukemia (CML) following a chemotherapy-induced loss of the Ph1 chromosome. Blood 56: 356–360PubMedGoogle Scholar
  34. 34.
    Sokal J (1980) Significance of Ph1-negative marrow cells in Ph1-positive chronic granulocytic leukemia. Blood 56: 1072–1076PubMedGoogle Scholar
  35. 35.
    Oguma S, Takatsuki K, Uchino H, Kamada N, Oguma N, Kuramoto A (1982) Factors influencing survival in Philadelphia chromosome positive chronic myelocytic leukemia. Cancer 50: 2928–2934PubMedCrossRefGoogle Scholar
  36. 36.
    Sakurai M, Hayata I, Sandberg AA (1976) Prognostic value of chromosomal findings in Ph1-positive chronic myelocytic leukemia. Cancer Res 36: 313–318PubMedGoogle Scholar
  37. 37.
    Hagemeijer A, Smit EME, Lówenberg B, Abels J (1979) Chronic myeloid leukemia with permanent disappearance of the Ph1 chromosome and development of new clonal subpopulations. Blood 53: 1–14PubMedGoogle Scholar
  38. 38.
    Appelbaum FR, Najfeld V, Singer JW (1983) Chronic myelogenous leukemia. Prolonged survival with spontaneous decline in the frequency of Ph1-positive cells and subsequent development of mixed Ph1-positive and Ph1-negative blast crisis. Cancer 51: 149–153PubMedCrossRefGoogle Scholar
  39. 39.
    Lisker R, Casas L, Mutchinick O, Pérez-Chávez F, Labardini J (1980) Late-appearing Philadelphia chromosome in two patients with chronic myelogenous leukemia. Blood 56: 812–814PubMedGoogle Scholar
  40. 40.
    Fialkow PJ, Martin PJ, Najfeld V, Penfold GK, Jacobson RJ, Hansen JA (1981) Evidence for a multistep of chronic myelogenous leukemia. Blood 58: 158–163PubMedGoogle Scholar
  41. 41.
    Hagemeijer A, Stenfert Kroeze WF, Abels J (1980) Cytogenetic follow-up of patients with nonlymphocytic leukemia. I. Philadelphia chromosome-positive chronic myeloid leukemia. Cancer Genet Cytogenet 2: 317–326CrossRefGoogle Scholar
  42. 42.
    Motomura S, Ogi K, Horie M (1973) Monoclonal origin of acute transformation of chronic myelogenous leukemia. Acta Haematol (Basel) 49: 300–305CrossRefGoogle Scholar
  43. 43.
    Janossy G, Woodruff RK, Paxton A, Greaves MF, Capellaro D, Kirk B, Innes EM, Lewis C, Eden OB, Catovsky D, Hoffbrand AV (1978) Membrane marker and cell separation studies in Ph1-positive leukemia. Blood 51: 861–877PubMedGoogle Scholar
  44. 44.
    Griffin JD, Todd RF III, Ritz J, Nadler LM, Canellos GP, Rosenthal D, Gallivan M, Beveridge RP, Weinstein H, Karp D, Schlossman F (1983) Differentiation patterns in the blastic phase of chronic myeloid leukemia. Blood 61: 85–91PubMedGoogle Scholar
  45. 45.
    Bennett JM, Catovsky D, Daniel M-T, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukaemias. Br J Haematol 33: 451–458PubMedCrossRefGoogle Scholar
  46. 46.
    Alimena G, Dallapiccola B, Gastaldi R, Mandelli F, Brandt L, Mitelman F, Nilsson PG (1982) Chromosomal, morphological and clinical correlations in blastic crisis of chronic myeloid leukaemia. A study of 69 cases. Scand J Haematol 28: 103–117PubMedCrossRefGoogle Scholar
  47. 47.
    Fleischman EW, Prigogina EL, Volkova MA, Frenkel MA, Zakhartchenko NA, Konstantinova LN, Puchkova GP, Balakirev SA (1981) Correlations between the clinical course, characteristics of blast cells, and karyotype patterns in chronic myeloid leukemia. Hum Genet 58: 285–293PubMedCrossRefGoogle Scholar
  48. 48.
    Sandberg AA, Hossfeld DK (1970) Chromosomal abnormalities in human neoplasia. Annu Rev Med 21: 379–408PubMedCrossRefGoogle Scholar
  49. 49.
    Garson OM (1979) Chromosome-banding techniques and their implication in hematology. Prog Hematol 21: 83–114Google Scholar
  50. 50.
    First International Workshop in Chromosomes in Leukemia (1978) Chromosomes in acute non-lymphocytic leukaemia. Br J Haematol 39: 311–316CrossRefGoogle Scholar
  51. 51.
    Hagemeijer A, Hahlen K, Abels J (1981) Cytogenetic follow-up of patients with nonlymphocytic leukemia. II. Acute nonlymphocytic leukemia. Cancer Genet Cytogenet 3: 109–124PubMedCrossRefGoogle Scholar
  52. 52.
    Takeuchi J, Ohshima T, Amaki I (1981) Cytogenetic studies in adult acute leukemias. Cancer Genet Cytogenet 4: 293–302PubMedCrossRefGoogle Scholar
  53. 53.
    Prigogina EL, Fleischman EW, Puchkova GP, Kulagina OE, Majakova SA, Balakirev SA, Prenkel MA, Khvatova NV, Peterson IS (1979) Chromosomes in acute leukemia. Hum Genet 53: 5–16PubMedCrossRefGoogle Scholar
  54. 54.
    Fitzgerald PH, Morris CM, Fraser GJ, Giles LM, Hamer JW, Heaton DC, Beard MEJ (1983) Nonrandom cytogenetic changes in New Zealand patients with acute myeloid leukemia. Cancer Genet Cytogenet 8: 51–66PubMedCrossRefGoogle Scholar
  55. 55.
    Mitelman F, Nilsson PG, Brandt L, Alimena G, Gastaldi R, Dallapiccola B (1981) Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia. Cancer Genet Cytogenet 4: 197–214PubMedCrossRefGoogle Scholar
  56. 56.
    Rowley JD, Golomb HM, Vardiman JW (1981) Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease. Blood 58: 759–767PubMedGoogle Scholar
  57. 57.
    Rowley JD, Alimena G, Garson OM, Hagemeijer A, Mitelman F, Prigogina EL (1982) A collaborative study of the relationship of the morphological type of acute nonlymphocytic leukemia with patient age and karyotype. Blood 59: 1013–1021PubMedGoogle Scholar
  58. 58.
    Fialkow PJ, Singer JW, Adamson JW, Vaidya K, Dow LW, Ochs J, Moohr JW (1981) Acute nonlymphocytic leukemia: heterogeneity of stem cell origin. Blood 57: 1068–1073PubMedGoogle Scholar
  59. 59.
    Zuelzer WW, Inoue S, Thompson RI, Ottenbreit MJ (1976) Long-term cytogenetic studies in acute leukemia of children; the nature of relapse. Am J Hematol 1: 143–190PubMedCrossRefGoogle Scholar
  60. 60.
    Nowell PC (1978) Tumors as clonal proliferation. Virchows Arch [Cell Pathol] 29: 145–150Google Scholar
  61. 61.
    Morse HG, Ducore JM, Hays T, Peakman D, Robinson A (1978) Multiple leukemic clones in acute leukemia of childhood. Hum Genet 40: 269–278PubMedCrossRefGoogle Scholar
  62. 62.
    Testa JR, Kanofsky JR, Rowley JD, Baron JM (1981) Multiple cytogenetically abnormal clones in two polycythemia vera patients. Hum Genet 57: 165–168PubMedCrossRefGoogle Scholar
  63. 63.
    McCulloch EA, Howatson AF, Buick RN, Minden MD, Izaguirre CA (1979) Acute myeloblasts leukemia considered as a clonal hemopathy. Blood Cells 5: 261–282PubMedGoogle Scholar
  64. 64.
    Lawler SD, Summersgill B, Clink HM, McElwain TJ (1980) Cytogenetic follow-up study of acute non-lymphocytic leukaemia. Br J Haematol 44: 395–405PubMedCrossRefGoogle Scholar
  65. 65.
    Testa JR, Mintz U, Rowley JD, Vardiman JW, Golomb HM (1979) Evolution of karyotypes in acute nonlymphocytic leukemia. Cancer Res 39: 3619–3627PubMedGoogle Scholar
  66. 66.
    Li YS, Khalid G, Hayhoe FGJ (1983) Correlation between chromosomal pattern, cytological subtypes, response to therapy, and survival in acute myeloid leukaemia. Scand J Haematol 30: 265–277PubMedCrossRefGoogle Scholar
  67. 67.
    Kaneko Y, Rowley JD, Variakojis D, Chilcote RR, Check I, Sakurai M (1982) Correlation of karyotype with clinical features in acute lymphoblastic leukemia. Cancer Res 42: 2918–2929PubMedGoogle Scholar
  68. 68.
    Whang-Peng J, Knutsen T, Ziegler J, Leventhal B (1976) Cytogenetic studies in acute lymphocytic leukemia: special emphasis in long-term survival. Med Pediat Oncol 2: 333–351CrossRefGoogle Scholar
  69. 69.
    Secker-Walker LM, Swansbury GJ, Lawler SD, Hardisty RM (1979) Bone marrow chromosomes in acute lymphoblastic leukaemia: a long-term study. Med Pediat Oncol 7: 371–385CrossRefGoogle Scholar
  70. 70.
    Third International Workshop on Chromosomes in Leukemia (1981) Chromosomes in acute lymphoblastic leukemia. Cancer Genet Cytogenet 4: 101–137CrossRefGoogle Scholar
  71. 71.
    Van den Berghe H, David G, Broeckaert-van Orshoven A, Louwagie A, Verwilghen R, Casteels-van Daele M, Eggermont E, Eeckels R (1979) A new chromosome anomaly in acute lymphoblastic leukemia ( ALL ). Hum Genet 46: 173–180PubMedCrossRefGoogle Scholar
  72. 72.
    Arthur DC, Bloomfield CD, Lindquist LL, Nesbit ME Jr (1982) Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance. Blood 59: 96–99PubMedGoogle Scholar
  73. 73.
    Parkin JL, Arthur DC, Abramson CS, McKenna RW, Kersey JH, Heideman RL, Brunning RD (1982) Acute leukemia associated with the t (4; 11) chromosome rearrangement: Ultrastructural and immunologic characteristics. Blood 60: 1321–1331PubMedGoogle Scholar
  74. 74.
    Inoue S, Ravindranath Y, Zuelzer WW (1975) Cytogenetic analysis of erythroleukaemia in two children — Evidence of nonmalignant nature of erythron. Scand J Haematol 14: 129–139PubMedCrossRefGoogle Scholar
  75. 75.
    Blackstock AM, Garson OM (1974) Direct evidence for involvement of erythroid cells in acute myeloblasts leukaemia. Lancet II: 1178–1182Google Scholar
  76. 76.
    Brandt L, Mitelman F, Sjögren U (1975) Megaloblastic changes and chromosome abnormalities of erythropoietic cells in acute myeloid leukaemia. Acta Haematol 54: 280–283PubMedCrossRefGoogle Scholar
  77. 77.
    Holland JF (1970) Epidemic acute leukemia. N Engl J Med 283: 1165–1166PubMedCrossRefGoogle Scholar
  78. 78.
    Hossfeld DK, Holland JF, Cooper RG, Ellison RR (1975) Chromosome studies in acute leukemias developing in patients with multiple myeloma. Cancer Res 35: 2808–2813PubMedGoogle Scholar
  79. 79.
    Rowley JD, Golomb HM, Vardiman J (1977) Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin disease and non-Hodgkin lymphomas. Blood 50: 759–769Google Scholar
  80. 80.
    Sandberg AA, Abe S, Kowalczyk JR, Zedgenidze A, Takeuchi J, Kakati S (1982) Chromosomes and causation of human cancer and leukemia. L Cytogenetics of leukemias complication other diseases. Cancer Genet Cytogenet 7: 95–136PubMedCrossRefGoogle Scholar
  81. 81.
    Pedersen-Bjergaard J, Philip P, Mortensen BT, Ersboll J, Jensen G, Panduro J, Thomsen M (1981) Acute nonlymphocytic leukemia. Preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. Clinical and cytogenetic characteristics and results of in vitro culture of bone marrow and HLA typing. Blood 57: 712–723PubMedGoogle Scholar
  82. 82.
    Mitelman F, Brandt L, Nilsson PG (1978) Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings, and bone marrow chromosomes in acute nonlymphocytic leukemia. Blood 52: 1229–1237PubMedGoogle Scholar
  83. 83.
    Golomb HM, Alimena G, Rowley JD, Vardiman JW, Testa JR, Sovik C (1982) Correlation of occupation and karyotype in adult with acute nonlymphocytic leukemia. Blood 60: 404–411PubMedGoogle Scholar
  84. 84.
    Lawler SD, Summersgill BM, Clink HMcD, McElwain TJ (1979) Chromosomes, leukaemia, and occupational exposure to leukaemogenic agents. Lancet 2: 853–854PubMedCrossRefGoogle Scholar
  85. 85.
    Rowley JD (1981) Association of specific chromosome abnormalities with type of acute leukemia and with patient age. Cancer Res 41: 3407–3410PubMedGoogle Scholar
  86. 86.
    Brandt L, Mitelman F, Nilsson PG (1983) Chromosome pattern and survival in acute non-lymphocytic leukaemia in relation to age and occupational exposure to potential mutagenic/carcinogenic agents. Scand J Haematol 30: 227–231PubMedCrossRefGoogle Scholar
  87. 87.
    Ezdinli EZ, Sokal JE, Crosswhite L, Sandberg AA (1970) Philadelphia-chromosome-positive and — negative chronic myelocytic leukemia. Ann Intern Med 72: 175–182PubMedGoogle Scholar
  88. 88.
    Hossfeld DK (to be published) Die chronische myeloische Leukämie. In: Gross R, Schmidt CG (Hrsg) Klinische Onkologie. Thieme, StuttgartGoogle Scholar
  89. 89.
    Lawler SD (1982) Significance of chromosome abnormalities in leukemia. Semin Hematol 19: 257–272PubMedGoogle Scholar
  90. 90.
    Gomez GA, Sokal JE, Walsh D (1981) Prognostic features at diagnosis of chronic myelocytic leukemia. Cancer 47: 2470–2475PubMedCrossRefGoogle Scholar
  91. 91.
    Lawler SD, Lobb DS, Wiltshaw E (1974) Philadelphiachromosome positive bone marrow cells showing loss of the Y in males with chronic myeloid leukemia. Br J Haematol 27: 247–252PubMedCrossRefGoogle Scholar
  92. 92.
    Hossfeld DK (1980) Loss of the Y chromosome in chronic myeloid leukemia (CML). In: Tura S, Zaccaria (eds) Citogenetica Oncologica. Societa’ Editrice Esulapio, Bologna, pp 177–181Google Scholar
  93. 93.
    Potter AM, Watmore AE, Cooke P, Lilleyman JS, Sokol RJ (1981) Significance of non-standard Philadelphia chromosomes in chronic granulocytic leukemia. Br J Cancer 44: 51–54PubMedCrossRefGoogle Scholar
  94. 94.
    Sandberg AA (1980) The cytogenetics of chronic myelocytic leukemia (CML): chronic phase and blastic crisis. Cancer Genet Cytogenet 1: 217–228CrossRefGoogle Scholar
  95. 95.
    Sadamori N, Gomez GA, Sandberg AA (1983) Chromosomes and causation of human cancer and leukemia: IL. Therapeutic and prognostic value of chromosomal findings during acute phase in Ph1-positive chronic myeloid leukemia. Hematol Oncol 1: 77–83PubMedCrossRefGoogle Scholar
  96. 96.
    Olâh E, Râk K (1981) Prognostic value of chromosomal findings in the blast phase of Ph1-positive chronic myeloid leukaemia ( CML ). Int J Cancer 27: 287–295PubMedCrossRefGoogle Scholar
  97. 97.
    Sakurai M, Sandberg AA (1973) Prognosis of acute myeloblasts leukemia: chromosomal correlation. Blood 41: 93–104PubMedGoogle Scholar
  98. 98.
    Nilsson PG, Brandt L, Mitelman F (1977) Prognostic implications of chromosome analyses in acute nonlymphocytic leukemia. Leuk Res 1: 31–34CrossRefGoogle Scholar
  99. 99.
    Golomb HM, Vardiman JW, Rowley JD, Testa JR, Mintz U (1978) Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia. N Engl J Med 299: 613–619PubMedCrossRefGoogle Scholar
  100. 100.
    Hossfeld DK, Faltermeier M-T, Wendehorst E (1979) Beziehungen zwischen Chromosomen-befund und Prognose bei akuter nicht-lymphoblastischer Leukämie. Blut 38: 377–382PubMedCrossRefGoogle Scholar
  101. 101.
    Alimena G, Annino L, Balestrazzi P, Montuoro A, Dallapiccola B (1977) Cytogenetic studies in acute leukemias. Prognostic implications of chromosome imbalances. Acta Haematol (Basel) 58: 234–239CrossRefGoogle Scholar
  102. 102.
    Bernard P, Reiffers J, Lacombe F, Dachary D, David B, Boisseau MR, Broustet A (1982) Prognostic value of age and bone marrow karyotype in 78 adults with acute myelogenous leukemia. Cancer Genet Cytogenet 7: 153–163PubMedCrossRefGoogle Scholar
  103. 103.
    Fitzgerald PH, Hamer JW (1976) Karyotype and survival in human acute leukemia. J Natl Cancer Inst 56: 459–462PubMedGoogle Scholar
  104. 104.
    Berger R, Bernheim A, Daniel M-T, Valensi F, Sigaux F, Flandrin G (1982) Cytologic characterization and significance of normal karyotypes in t (8; 21) acute myeloblasts leukemia. Blood 59: 171–176PubMedGoogle Scholar
  105. 105.
    Brodeur GM, Williams DL, Kalwinsky DK, Williams KJ, Dahl GV (1983) Cytogenetic features of acute nonlymphoblastic leukemia in 73 children and adolescents. Cancer Genet Cytogenet 8: 93–105PubMedCrossRefGoogle Scholar
  106. 106.
    Kamada N, Dohy H, Okada K, Oguma N, Kuramoto A, Tanaka K, Uchino H (1981) In vivo and in vitro activity of neutrophil alkaline phosphatase in acute myelocytic leukemia with 8; 21 translocation. Blood 58: 1213–1217PubMedGoogle Scholar
  107. 107.
    Fourth International Workshop on Chromosomes in Leukemia (1983) Cancer Genet Cytogenet (to be published)Google Scholar
  108. 108.
    Second International Workshop on Chromosomes in Leukemia (1980) Morphological analysis of acute promyelocytic leukemia (M3) and t (8; 21). Cancer Genet Cytogenet 2: 89–113CrossRefGoogle Scholar
  109. 109.
    Trujillo JM, Cork A, Ahearn MJ, Youness EL, McCredie KB (1979) Hematologic and cytologic charaterization of 8/21 translocation acute granulocytic leukemia. Blood 53: 695–706PubMedGoogle Scholar
  110. 110.
    Tricot G, Broeckaert-van Orshoven A, Casteels-van Daele M, van den Berghe H (1981) 8/21 translocation in acute myeloid leukemia. Scand J Haematol 26: 168–176PubMedCrossRefGoogle Scholar
  111. 111.
    Oshimura M, Ohyashiki K, Mori M, Terada H, Takaku F (1982) Cytogenetic and hematologic findings in acute myelogenous leukemia, M2 according to the FAB classification. Gan 73: 212–216PubMedGoogle Scholar
  112. 112.
    Fraser J, Hollings PE, Fitzgerald PH, Day WA, Clark V, Heaton DC, Hamer JW, Beard MEJ (1981) Acute promyelocytic leukemia: cytogenetics and bone-marrow culture. Int J Cancer 27: 167–173PubMedCrossRefGoogle Scholar
  113. 113.
    Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1980) A variant form of hypergranular promyelocytic leukaemia ( M3 ). Br J Haematol 44: 169–170PubMedCrossRefGoogle Scholar
  114. 114.
    Berger R, Bernheim A, Daniel MT, Valensi F, Flandrin G, Bernard J (1979) Translocation t (15; 17), leucémie aiguë promye’locytaire et non promyélocytaire. Nouv Rev Fr Hematol 21: 117–131PubMedGoogle Scholar
  115. 115.
    Berger R, Bernheim A, Weh H-J, Daniel M-T, Flandrin G (1980) Cytogenetic studies on acute monocytic leukemia. Leuk Res 4: 119–127PubMedCrossRefGoogle Scholar
  116. 116.
    Hagemeijer A, Hählen K, Sizoo W, Abels J (1982) Translocation (9; 11) (p21; q23) in three cases of acute monoblastic leukemia. Cancer Genet Cytogenet 5: 95–105PubMedCrossRefGoogle Scholar
  117. 117.
    Dewald GW, Morrison-DeLap SJ, Schuchard KA, Spurbeck JL, Pierre RV (1983) A possible specific chromosome marker for monocytic leukemia: three more patients with t (9; 11) (p22; q21), and another with t (11; 17) (q24; q21), each with acute monoblastic leukemia. Cancer Genet Cytogenet 8: 203–212PubMedCrossRefGoogle Scholar
  118. 118.
    Weh H-J, Kuse R, Graeven U, Hausmann K, Hossfeld DK (1983) Cytogenetic findings in patients with acute myelogenous leukemia (AML). J Cancer Res Clin Oncol 105 (abstract)Google Scholar
  119. 119.
    Seeker-Walker LM, Lawler SD, Hardisty RM (1978) Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis. Br Med J 2: 1529–1530CrossRefGoogle Scholar
  120. 120.
    Wilhams DL, Tsiatis A, Brodeur GM, Look AT, Melvin SL, Bowman WP, Kalwinsky DK, Rivera G, Dahl GV (1982) Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. Blood 60: 864–871Google Scholar
  121. 121.
    Third International Workshop on Chromosomes in Leukemia (to be published) Chromosomal abnormalities identify high risk patients with acute lymphoblastic leukemia. Cancer ResGoogle Scholar
  122. 122.
    Hossfeld DK, Leder L-D, Wetter O, Zschaber R, Schmidt CG (1981) Philadelphia-Chromosom-positive akute Leukämie. In: Scheurlen PG, Pees HW (Hrsg) Aktuelle Therapie bösartiger Bluterkrankungen. Springer, Berlin Heidelberg New York, S 42–45Google Scholar
  123. 123.
    Berger R, Bernheim A, Brouet JC, Daniel MT, Flandrin G (1979) , (8; 14) translocation in a Burkitt’s type of lymphoblastic leukaemia ( L3 ). Br J Haematol 43: 87–90PubMedCrossRefGoogle Scholar
  124. 124.
    Mitelman F, Andersson-Anvret M, Brandt L, Catovsky D, Klein G, Manolov G, Manolova Y, Mark-Vendel E, Nilsson PG (1979) Reciprocal 8; 14 translocation in EBV-negative B-cell acute lymphocytic leukemia with Burkitt-type cells. Int J Cancer 24: 27–33PubMedCrossRefGoogle Scholar
  125. 125.
    Weh J-J, Kuse R, Hausmann K, Hossfeld DK (1983) Translocation t(4; 11): prognostische Bedeutung bei akuter lymphatischer Leukämie ( ALL ). Verh Dtsch Ges Inn Med 89: 1005–1008Google Scholar
  126. 126.
    Neel BG, Jhanwar SC, Chaganti RSK, Hayward WS (1982) Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sei USA 79: 7842–7846CrossRefGoogle Scholar
  127. 127.
    Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S, Leder P (1982) Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sei USA 79:7837–7841128. Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Groce CM (1982) Human c-myc one gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sei USA 79: 7824–7827CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • D. K. Hossfeld
    • 1
  • H.-J. Weh
    • 1
  1. 1.Abteilung für Onkologie und HämatologieMedizinische UniversitätsklinikHamburg 20Germany

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