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Current Understanding of Virus Etiology in Leukemia

  • Chapter
Leukemia

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 93))

  • 81 Accesses

Abstract

Epidemiological studies demonstrate that irradiation, genetic factors, immunological deficiencies, drugs, and environmental agents represent risk factors for the development of human leukemia, but cannot be considered common causes of this disease [1]. The same studies show that human leukemias are clearly not acute infectious diseases in the usual sense. In fact, tumor viruses or their footprints have been found only in a minority of human leukemias and lymphomas in spite of considerable efforts, and their role as possible etiological agents or cofactors remains uncertain. These observations and the recognition of certain preleukemic states which are not neoplastic in themselves but can convert to overt leukemia support the concept of a multifactorial etiology and/or multistep development of human leukemias. Why then pursue the concept of a viral etiology in human leukemias? There are four main reasons why the virus approach to leukemia remains an important issue: (a) Viruses are the cause of naturally occurring leukemias in several animal species including primates; (b) viruses have been associated regularly and repeatedly with certain forms of human leukemias and lymphomas; (c) a viral etiology may be obscured in human leukemias by several factors, such as long latency period, requirement for unknown cofactors, vertical transmission of the agent, congenital infection of the embryo, etc., all of which are known to occur in virus-induced leukemias in animals; and (d) the study of oncogenesis by viruses has contributed and continues to contribute a great deal to our knowledge of the molecular events and basic mechanisms involved in carcinogenesis in general.

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    R. Hehlmann, H. Schetters, C. Leib-Mösch & V. Erfle

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Hehlmann, R., Schetters, H., Leib-Mösch, C., Erfle, V. (1984). Current Understanding of Virus Etiology in Leukemia. In: Thiel, E., Thierfelder, S. (eds) Leukemia. Recent Results in Cancer Research, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82249-0_1

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