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Therapeutic Activity of Medroxyprogesterone Acetate in Metastatic Breast Cancer: A Correlation Between Estrogen Receptors and Various Dosages

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Clinical Interest of Steroid Hormone Receptors in Breast Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 91))

Abstract

It has been known for a relatively long time that progestogens, and especially medroxyprogesterone acetate (MPA), induce objective regression of the neoplasia in women with metastatic breast cancer. Some authors have recently reported [1, 7–9] that the response to MPA may be increased by employing high daily dosages. On this basis, we tested different dosages of MPA in patients who had become resistant to combined chemotherapy. Furthermore, we correlated the response of the patient with estrogen receptor status of the tumor.

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References

  1. Amadori D, Ravaioli A, Barbanti F (1977) The use of medroxyprogesterone acetate in high doses in palliative treatment of advanced mammary carcinoma (clinical experience with 44 cases). Minerva Med 68: 3967–3980

    PubMed  CAS  Google Scholar 

  2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248–259

    Article  PubMed  CAS  Google Scholar 

  3. De Lena M, Brambilla C, Volagussa P, Bonadonna G (1979) High dose medroxyprogesterone acetate in breast cancer resistant to endocrine and cytotoxic therapy. Cancer Chemother Pharmacol 2: 175–180

    Article  PubMed  Google Scholar 

  4. De Lena M, Brambilla C, Jirillo A (1980) Tamoxifen efficacy in advanced breast cancer previously treated with endocrine and cytotoxic therapy. Tumori 66: 339–348

    PubMed  Google Scholar 

  5. Di Fronzo G, Bertuzzi A, Ronchi E (1968) An improved criterion for the evaluation of estrogen receptor binding data in human breast cancer. Tumori 64: 259–266

    Google Scholar 

  6. Ganzina F (1979) High dose medroxyprogesterone acetate (MPA) treatment in advanced breast cancer. A review. Tumori 65: 563–585

    PubMed  CAS  Google Scholar 

  7. Pannuti F, Martoni A, Lenaz CR, Piana E, Manni P (1978) A possible new approach to the treatment of metastatic breast cancer: Massive dose of medroxyprogesterone acetate. Cancer Treat Rep 62: 499–504

    PubMed  CAS  Google Scholar 

  8. Pannuti F, Martoni A, Di Marco AR, Piana E, Saccani F, Becchi G, Mattioli G, Barbanti F, Marra GA, Persiani W, Cacciari L, Spagnuolo F, Polenzana D, Rocchetta G (1979) Prospective, randomized clinical trial of two different high dosages of medroxyprogesterone acetate ( MPA) in the treatment of metastatic breast cancer. J Cancer 15: 593–601

    CAS  Google Scholar 

  9. Robustelli Della Cuna G, Calciati A, Bernando Strada MR, Bumma C, Campio L (1978) High dose medroxyprogesterone acetate (MPA) treatment in metastatic carcinoma of the breast: a due response evolution. Tumori 64: 143–150

    Google Scholar 

  10. Scatchard G (1949) The attraction of protein for small molecules and ions. Ann NY Acad Sci 51: 660–672

    Article  CAS  Google Scholar 

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© 1984 Springer-Verlag Berlin · Heidelberg

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De Lena, M., Villa, S., Di Fronzo, G. (1984). Therapeutic Activity of Medroxyprogesterone Acetate in Metastatic Breast Cancer: A Correlation Between Estrogen Receptors and Various Dosages. In: Leclercq, G., Toma, S., Paridaens, R., Heuson, J.C. (eds) Clinical Interest of Steroid Hormone Receptors in Breast Cancer. Recent Results in Cancer Research, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82188-2_34

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  • DOI: https://doi.org/10.1007/978-3-642-82188-2_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82190-5

  • Online ISBN: 978-3-642-82188-2

  • eBook Packages: Springer Book Archive

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