Abstract
In the story of human breast cancer, two major findings markedly modified the clinical approach to treatment. Both belong to endocrinology. The first brought to light the hormone dependency of certain tumors and paved the way for ablative endocrine surgery [1]. This, however, did not help in the selection of patients before the initiation of treatment. The second was the discovery of the estrogen receptor (ER) machinery in normal target cells and the same mechanism of hormone action in tumor target tissue [5,6]. This opened up a new area in the knowledge of breast cancer. Further investigations demonstrated that breast tumors contain receptors for other steroids, some of whose functions have still not been elucidated. Progesterone receptors (PgR) have a unique place alongside ER since their synthesis has been demonstrated to be both estrogen and estrogen receptor dependent in several target tissues, such as endometrium, and in the mammary tumor epithelial cell line [2, 3]. In view of this, it was suggested that the existence and the quantity of ER and PgR might be regulated, even in tumor tissue. To test this hypothesis we analyzed tumor receptor contents in relation to endocrine parameters, menopausal status, and plasma estrogen and progesterone levels in 621 breast cancer patients treated in our institute.
This work was supported in part by the Institut National de la Santé et de la Recherche Médicale (ATP 24-75-47 and CRAT 76-4-490) and the Federation Française des Centres de Lutte contre le Cancer
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References
Huggins CB, Dao TL (1953) Adrenalectomy and oophorectomy in treatment of advanced carcinoma of the breast. JAMA 151: 1388–1394
Horwitz K, McGuire WL (1975) Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science 189: 726–727
Horwitz K, McGuire WL (1978) Estrogen control of progesterone receptors in human breast cancer. J Biol Chem 253: 2273–2278
Janne O, Isoma V, Isotalo H, Kokko E, Vierikko P (1978) Uterine estrogen and progestin receptors and their regulation. Ups J Med Sci Suppl 22: 62–70
Jensen E, Block GF, Smith S, Kyser K, DeSombre ER (1971) Estrogen receptors and breast cancer response to adrenalectomy. Natl Cancer Inst Monogr 34: 55–70
Jensen EV, DeSombre ER, Jungblut P (1967) Estrogen receptors in hormone responsive tissue and tumors. In: Wissler RW, Dao TL, Wood S (eds) Endrogenous factors influencing breast tumor balance. University of Chicago Press, Chicago, pp 15–68
McGuire WL (ed) (1978) Hormones, receptors, and breast cancer. Raven, New York
McGuire WL (1980) Steroid hormone receptors in breast cancer treatment strategy. Recent Prog Horm Res 36: 135–156
Milgrom E, Luu Thi M, Atger M, Baulieu EE (1974) Mechanism regulating the concentration and the conformation of progesterone receptor(s) in the uterus. J Biol Chem 248: 6366–6374
Nagai R, Kataoka M, Kobayash S, Ishihara K, Tobioka N, Nakashima K, Naruse M, Saito K, Sakuma S (1979) Estrogen and progesterone receptors in human breast cancer with concomitant assay of plasma 17/3 estradiol, progesterone and prolactin levels. Cancer Res 39: 1835–1840
Saez S, Martin PM, Chouvet CD (1978) Estradiol and progesterone receptor levels in human breast adenocarcinoma in relation to plasma estrogen and progesterone levels. Cancer Res 38: 3468–3473
Saez S (1974) Corticotrophin secretion in relation to breast cancer. In: Stoll E (ed) Mammary cancer and neuroendocrine therapy. Butterworth, London, pp 101–122
Vihko R, Janne O, Kontula K, Syrjala P (1980) Female sex steroid receptor status in primary and metastatic breast carcinoma and its relationship to serum and peptide hormone levels. Int J Cancer 26: 13–21
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© 1984 Springer-Verlag Berlin · Heidelberg
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Saez, S., Chouvet, C. (1984). Influence of Endogenous Hormone Levels on Tumor Estradiol and Progesterone Receptors. In: Leclercq, G., Toma, S., Paridaens, R., Heuson, J.C. (eds) Clinical Interest of Steroid Hormone Receptors in Breast Cancer. Recent Results in Cancer Research, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82188-2_21
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DOI: https://doi.org/10.1007/978-3-642-82188-2_21
Publisher Name: Springer, Berlin, Heidelberg
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