Advertisement

Die Anwendung von Diuretika bei der akuten und chronischen Herzinsuffizienz

  • F. Krück
Part of the Handbuch der inneren Medizin book series (INNEREN, volume 9 / 4)

Zusammenfassung

Zu den pathophysiologischen Folgeerscheinungen einer nachlassenden Herzleistung gehört der Verlust der Fähigkeit der Niere, Salz und Wasser in ausreichender Menge auszuscheiden. Wenn mehr Natrium zugeführt wird, als eliminiert werden kann, resultiert eine positive Flüssigkeitsbilanz, die sich im interstitiellen Raum als Ödem, in parenchymatösen Organen (Leber, Lunge) als Kongestion und in serösen Höhlen (Pleura, Perikard, Peritoneum) als Transsudat manifestiert, und in bestimmten Gefäßbezirken zum Druckanstieg führt.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Abe Y, Dixon F, McNay JL (1970) Dissociation between autoregulation of renal blood flow and glomerular filtration rate. Am J Physiol 219:986–993PubMedGoogle Scholar
  2. Abramow M (1975) Effects of ethacrynic acid on the isolated collecting tubule. J Clin Invest 53:796–804Google Scholar
  3. Aikawa JK, Fitz RH (1956) Exchangeable potassium content of the body in congestive heart failure: Changes during treatment. Circulation 14:1093–1098PubMedGoogle Scholar
  4. Alter S, Cushman P, Hilton JG (1967) A new guanidine diuretic, amipramizide. Reduction of the kaliuretic effect of ethacrynic acid in man. Clin Pharmacol Ther 8:243–248PubMedGoogle Scholar
  5. Amery A, Bulpit C, de Schaepdryver A, Fagard R, Hellmans J, Mutsers A, Berthaux P, Deruyttere M, Dollery C, Forette F, Lund-Johansen P, Tuomilehto J (1978) Glucose intolerance during diuretic therapy. Results of trial by the European working party on hypertension in the elderly. Lancet I:681–683Google Scholar
  6. Ames RP, Hill P (1976a) Elevation of serum lipids during diuretic therapy of hypertension. Am J Med 61:748–757Google Scholar
  7. Ames RP, Hill P (1976b) Increase in serum-lipids during treatment of hypertension with chlorthalidone. Lancet I:721–723Google Scholar
  8. Ames RP, Hill P (1978) Raised serum lipid concentrations during diuretic treatment of hypertension : a study of predictive indexes. Clin Sci Mol Med 55:311Google Scholar
  9. Anderson J, Godfrey BE, Hill DM, Munro-Favre AD, Sheldon J (1971) A comparison of the effects of hydrochlorothiazide and of Frusemide in the treatment of hypertensive patients. Q J Med 40:541–560PubMedGoogle Scholar
  10. Andreasen F, Sigurd B, Steness E (1980) Effect of probenecid on excretion and natriuretic action of furosemide. Eur J Clin Pharmacol 18:489PubMedGoogle Scholar
  11. Andreasen F, Christensen CK, Jacobsen FK, Jansen J, Mogensen CE, Ledersen OL (1982) The individual variation in pharmacokinetics and pharmacodynamics of furosemide in young normal male subjects. Eur J Clin Invest 12:247–255PubMedGoogle Scholar
  12. Antonello A, Cargnielli G, Ferrari M, Melacini P, Montanaro D (1976) Effect of digoxin on plasma renin activity in man. Lancet II:850Google Scholar
  13. Asbury MJ, Gatenby PBB, O’Sullivan N, Bourke E (1972) Bumetanide: a potent new loop diuretic. Br Med J I:211–213Google Scholar
  14. Ashraf N, Locksley R, Arieff AI (1981) Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients. Am J Med 70:1163–1168PubMedGoogle Scholar
  15. Avery GS (1976) Drug treatment: Principles and practice of clinical pharmacology and therapeutics. Mass Publishing Science GroupGoogle Scholar
  16. Baba WI, Tudhope GR, Wilson GM (1962) Triamterene, a new diuretic drug. Br Med J II:756–764Google Scholar
  17. Baba WI, Lant AF, Smith AJ, Townshend MM, Wilson GM (1968) Pharmacological effects in animals and normal human subjects of the diuretic amiloride hydrochloride (MK 870). J Clin Pharmacol Ther 9:318–327Google Scholar
  18. Baer JE, Beyer KH (1966) Renal Pharmacology. Annu Rev Pharmacol 6:261–292PubMedGoogle Scholar
  19. Baer JE, Beyer KH (1972) Subcellular Pharmacology of natriuretic on potassium sparing drugs. Prog Biochem Pharmacol 7:59–93PubMedGoogle Scholar
  20. Baer PB, Navar LG (1973) Renal vasodilation and uncoupling of blood flow and filtration rate autoregulation. Kidney Int 4:12–21PubMedGoogle Scholar
  21. Baer JE, Leidy HL, Brooks AV, Beyer KH (1959a) The physiological disposition of chlorothiazide (Diuril) in the dog. J Pharmacol Exp Ther 125:295–302Google Scholar
  22. Baer JE, Russo HF, Beyer KH (1959b) Saluretic activity of hydrochlorthiazide (6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide) in the dog. Proc Soc Exp Biol Med 100:442–446Google Scholar
  23. Baer JE, Russo HF, Michaelson JK, Beyer KH (1962) A new class of diuretic-saluretic agents, the α,β-unsaturated ketone derivatives of aryloxyacetic acids. Pharmacologist 4:158 (Abstr)Google Scholar
  24. Baer JE, Michaelson JK, Russo HF, Beyer KH (1963) 2,3-Dichloro-4-(2 Methylenebutyryl)-Phenoxyacetic acid (I), a novel and potent diuretic-saluretic agent. Fed Proc 22:598 (Abstr)Google Scholar
  25. Baer JE, Michaelson JK, Mc Kinstry DN, Beyer KH (1964) A new class of diureticsaluretic agents. The α,β-unsaturated derivatives of aryloxyacetic acids. Proc Soc Exp Biol Med 115:87–90PubMedGoogle Scholar
  26. Baer JE, Michaelson JK, Jones CB, Russo HF, Beyer KH (1966a) Die Wirkung von 2,3-Dichlor-4-(2-methylenbutyryl)-phenoxy-essigsäure (Etacrynsäure) auf die Urinkonzentration und auf den renalen Soluten-Gradienten beim Hund. Arzneimittelforsch 16:373–380Google Scholar
  27. Baer JE, Mucha CM, Spitzer SA, Yee HW (1966b) A K +-sparing natriuretic pyrazinamide derivative. Fed Proc 25:197Google Scholar
  28. Baer JE, Iones CB, Spitzer SA, Russo HF (1967) The potassium sparing and natriuretic activity of N-amidino-3,5-diamino-6-chlorpyrazine-carboxamide hydrochloride dihydrate (amiloride hydrochloride). J Pharmacol Exp Ther 157:472–485PubMedGoogle Scholar
  29. Bailie MD, Crosslan K, Hook JB (1976) Natriuretic effect of furosemide after inhibition of prostaglandin synthetase. J Pharmacol Exp Ther 199:469–476PubMedGoogle Scholar
  30. Baitsch G, Bertel O, Burkart F, Steiner A, Vettiger K, Ritz R (1979) Haemodynamische Konsequenzen bei Herzinsuffizienzbehandlung mit Furosemid beim frischen Myokardinfarkt. Schweiz Med Wochenschr 109:1663–1669PubMedGoogle Scholar
  31. Barger AC (1966) Renal hemodynamic factors in congestive heart failure. Ann NY Acad Sci 139:276–284PubMedGoogle Scholar
  32. Barger AC, Muldowney FP, Liebowitz MR (1959) Role of kidney in the pathogenesis of congestive heart failure. Circulation 20:273–285PubMedGoogle Scholar
  33. Bathia ML, Singh I, Machanda SC, Khanna PK, Roy SB (1969) Effect of furosemide on pulmonary blood volume. Br Med J II:551–552Google Scholar
  34. Beerman B, Groschinsky-Grind M (1977) Pharmacokinetics of hydrochlorothiazide in man. Eur J Clin Pharmacol 12:297–303Google Scholar
  35. Beisenherz G, Koss FW, Klatt L, Binder B (1966) Distribution of radioactivity in the tissues and excretory products of rats and rabbits following administration of C14-hygroton. Arch Int Pharmacodyn Ther 161:75–79Google Scholar
  36. Belair EJ (1971) The renal pharmacology of metolazone, 3-methyl-3-O-tolyl-6-Sulfamyl-7-Chloro-1,2,3,4-tetrahydro-4-quinazolinone. Res Commun Chem Pathol Pharmacol 2:98–117PubMedGoogle Scholar
  37. Belair E, Kaiser F, van Denburg B, Borelli A, Lawlor R, Panasevich R, Yeenoski J (1969) Pharmacology of SR 720-22. Arch Int Pharmacodyn Ther 177:71–87PubMedGoogle Scholar
  38. Bell NH, Schedl HP, Bartter FC (1964) An explanation for abnormal water retention and hypoosmolality in congestive heart failure. Am J Med 36:351–360PubMedGoogle Scholar
  39. Bell PD, Navar LG (1982a) Cytoplasmatic calcium in the mediation of macula densa tubulo-glomerular feedback responses. Science 215:670–673Google Scholar
  40. Bell PD, Navar LG (1982b) Macula densa feedback control of glomerular filtration: Role of cytosolic calcium. Mineral-Electrolyte Metabol 8:61–77Google Scholar
  41. Beller G, Smith TW, Abelman WH, Haber E, Hood WB Jr (1971) Digitalis intoxication: A prospective clinical study with serum level correlations. N Engl J Med 284:989–997PubMedGoogle Scholar
  42. Benet LZ (1979) Pharmacokinetics/pharmacodynamics of furosemide in man: A review. J Pharmacokinet Biopharm 7:1–27PubMedGoogle Scholar
  43. Berchtold P, Cüppers HJ, Berger M (1981) Diuretika, Serum-Glucose und Diabetes mellitus. Dtsch Med Wochenschr 106:1712–1714PubMedGoogle Scholar
  44. Beresford HR (1970) Polydipsia, hydrochlorothiazide and water intoxication. JAMA 214:879–883PubMedGoogle Scholar
  45. Berg KJ, Loew D (1977) Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs. Scand J Clin Lab Invest 37:125–131PubMedGoogle Scholar
  46. Berg KJ, Iørstad S, Tromsdal A (1976) Studies on the clinical pharmacology of a new potent diuretic, Bay g 2821. Pharmacotherapeutica 1:319–332Google Scholar
  47. Beyer KH (1958) The mechanism of action of chlorothiazide. NY Acad Sci 71:363–379Google Scholar
  48. Beyer KH, Baer JE (1961) Physiological basis for the action of newer diuretic agents. Pharmacol Rev 13:517–562PubMedGoogle Scholar
  49. Beyer KH, Russo HF, Tillson EK, Miller AK, Verwey WF, Gass SR (1951) “Benemid”, p-(di-n-Propyl-sulfamyl)-benzoic acid: its renal affinity and its elimination. Am J Physiol 166:625–639PubMedGoogle Scholar
  50. Beyer KH, Baer JE, Russo HF, Haimbach AS (1957) Chlorothiazide (6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1 dioxide): the enhancement of sodium chloride excretion. Fed Proc 16:282Google Scholar
  51. Beyer KH, Baer JE, Michaelson JK, Russo HF (1965) Renotropic characteristics of ethacrynic acid: a phenoxyacetic saluretic diuretic agent. J Pharmacol Exp Ther 147:1–22PubMedGoogle Scholar
  52. Bhatia ML, Singh I, Manchanda SC, Khanna PK, Roy SB (1969) Effect of frusemide on pulmonary blood volume. Br Med J 2:551–552PubMedGoogle Scholar
  53. Biagi RW, Bapat BN (1967) Frusemide in acute pulmonary oedema. Lancet I:849Google Scholar
  54. Biber TUL (1977) Uptake of sodium in epithelia. Effect of Amiloride. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Thieme, Stuttgart, pp 58–63Google Scholar
  55. Biber TUL, Aceves J, Mandel LJ (1972) Potassium uptake across serosal surface of isolated frog skin epithelium. Am J Physiol 222:1366–1373PubMedGoogle Scholar
  56. Biddle TL, Yu PN (1979) Effect of furosemide on hemodynamics and lung water in acute pulmonary edema secondary to myocardial infarction. Am J Cardiol 43:86–90PubMedGoogle Scholar
  57. Birbari A (1972) Intrarenal factors in the control of renin secretion. Pfluegers Arch 337:29–38Google Scholar
  58. Birtch AG, Zakheim RM, Iones LG, Barger AC (1967) Redistribution of renal blood flow produced by furosemide and ethacrynic acid. Circ Res 21:869–878PubMedGoogle Scholar
  59. Boehringer K, Meier A, Weidmann P, Schiffl H, Mordasini R, Rissen W (1981) Einfluß von Hydrochlorothiazid/Amilorid allein oder in Kombination mit α-Methyldopa auf die Serumlipoproteine. Schweiz Med Wochenschr 111:525–530PubMedGoogle Scholar
  60. Bojs G, Lundvall O (1966) Effects of ethacrynic acid on renal function in man. Acta Med Scand 179:95–101PubMedGoogle Scholar
  61. Bourke E, Asbury JMA, O’Sullivan S, Gatenby PBB (1973) The sites of action of bumetanide in man. Eur J Pharmacol 23:283–289PubMedGoogle Scholar
  62. Bowman RH (1975) Renal secretion of [35S]furosemide and its depression by albumin binding. Am J Physiol 229:93–98PubMedGoogle Scholar
  63. Bowman RH, Arnow J, Weiner IM (1978) The effects of 2,4,6-Triaminopyrimidin on sodium and potassium excretion by the rat kidney: Comparison with Amiloride. J Pharmacol Exp Ther 206:207–217PubMedGoogle Scholar
  64. Brater DC (1978a) Increase in diuretic effect of chlorothiazide by probenecid. Clin Pharmacol Ther 23:259–265Google Scholar
  65. Brater DC (1978b) Effects of probenecid on furosemide response. Clin Pharmacol Ther 24:548–554Google Scholar
  66. Breckenridge A, Dollery CT, Welborn TA, Fraser R (1967) Glucose tolerance in hypertensive patients on long-term diuretic therapy. Lancet I:61–64Google Scholar
  67. Breslau N, Moses AM, Weiner IM (1976) The role of volume contraction on the hypocalciuric action of chlorothiazide. Kidney Int 10:164–170PubMedGoogle Scholar
  68. Brest AN, Moyer JH (1966) Clinical pharmacology of diuretic drugs. Am J Cardiol 17:626–630PubMedGoogle Scholar
  69. Brettel HR, Aikawa JK, Gordon GS (1960) Studies with chlorothiazide tagged with radioactive carbon (C14) in human beeings. Arch Intern Med 106:57–63Google Scholar
  70. Brickman AS, Coburn JW, Koppel MH, Peacock M, Massry SG (1971) The effect of hydrochlorothiazide administration on serum an urinary calcium in normal, hypoparathyroid and hyperparathyroid subjects: Studies on mechanisms. Isr J Med Sci 7:518–519PubMedGoogle Scholar
  71. Brickman AS, Massry SG, Coburn JW (1972) Changes in serum and urinary calcium during treatment with hydrochlorothiazide: Studies on mechanisms. J Clin Invest 51:945–954PubMedGoogle Scholar
  72. Briggs JP, Wright FS (1979) Feedback control of glomerular filtration rate: Site of the effector mechanism. Am J Physiol 236:F40–F47PubMedGoogle Scholar
  73. Brod J, Fejfar Z, Fejfarova MH (1954) Role of neurohumoral factors in genesis of renal haemodynamic changes in heart failure. Acta Med Scand 148:273–290PubMedGoogle Scholar
  74. Brody MJ, Hook JB, Blatt AH, Williamson HE (1969) Effect of several diuretics on autoregulation of renal blood flow. Arch Int Pharmacodyn Ther 180:114–120PubMedGoogle Scholar
  75. Brown TC, Davis JO, Johnston CI (1966) Acute responses in plasma renin and aldosterone secretion to diuretics. Am J Physiol 211:437–441PubMedGoogle Scholar
  76. Brummelen P van, Woerlee M, Schalekamp MAHD (1979) Long-term versus short-term effects of hydrochlorothiazide on renal hemodynamics in essential hypertension. Clin Sci 56:463–469PubMedGoogle Scholar
  77. Brunner FB (1967) Klinische Erfahrungen mit dem neuen Kaliumsparenden Diureticum Amilorid (Moduretic, Colectril, MK 870). Schweiz Med Wochenschr 97:1542–1548PubMedGoogle Scholar
  78. Bryant JM, Ts’ai Fan Yü, Berger L, Schwartz N, Torosdag S, Fletcher L, Fertig H, Schwartz MS, Quan RB (1962) Hyperuricemia induced by the administration of chlorthalidone and other sulfonamide diuretics. Am J Med 33:408–420PubMedGoogle Scholar
  79. Burg MB (1976) Tubular chloride transport and the mode of action of some diuretics. Kidney Int 9:189–197PubMedGoogle Scholar
  80. Burg MB (1977) The mechanism of action of diuretics in renal tubules. In: Wesson LG, Fanelli GM Jr (eds) Recent advances in renal physiology and pharmacology. Park Press, Baltimore, pp 99–109Google Scholar
  81. Burg MB, Green N (1973a) Function of the thick ascending limb of Henle’s loop. Am J Physiol 224:659–668Google Scholar
  82. Burg MB, Green N (1973b) Effect of ethacrynic acid on the thick ascending limb of Henle’s loop. Kidney Int 4:301–308Google Scholar
  83. Burg MB, Green N (1973c) Effect of Mersalyl on the thick ascending limb of Henle’s loop. Kidney Int 4:245–251Google Scholar
  84. Burg MB, Stoner L, Cardinal J, Green N (1973) Furosemide effect on isolated perfused tubules. Am J Physiol 225:119–124PubMedGoogle Scholar
  85. Burke TJ, Duchin KL (1979) Glomerular filtration during furosemide diuresis in the dog. Kidney Int 16:672–680PubMedGoogle Scholar
  86. Burke TJ, Robinson RR, Clapp JR (1972) Determinants of the effect of furosemide on the proximal tubule. Kidney Int 1:12–20PubMedGoogle Scholar
  87. Calesnick B, Christensen JA, Richter M (1966) Absorption and excretion of Furosemide — S35 in human subjects. Proc Soc Exp Biol Med 123:17–22PubMedGoogle Scholar
  88. Cannon PJ, Ames RP, Laragh JH (1963) Methylenebutyryl phenoxyacetic acid. JAMA 185:854–863PubMedGoogle Scholar
  89. Cannon PJ, Heinemann HO, Statson WB, Laragh JH (1965) Ethacrynic acid. Effectiveness and mode of action in man. Circulation 31:5–18PubMedGoogle Scholar
  90. Cannon PJ, Svahn DS, Demartini FE (1970) The influence of hypertonic saline infusions upon the fractional reabsorption of urate and other ions in normal and hypertensive man. Circulation 41:97–108PubMedGoogle Scholar
  91. Canton A Dal, Russo D, Gallo R, Conte G, Andreucci VE (1981) Muzolimine: A new heigh-ceiling diuretic suitable for patients with advanced renal disease. Br Med J 282:595–598Google Scholar
  92. Cassin S, Vogh B (1966) Effects of hydrochlorothiazide on renal blood flow and clearance of Para-Amino hippurate and Creatinine. Proc Soc Exp Biol Med 122:970–973PubMedGoogle Scholar
  93. Catell WR, Havard CWH (1962) Diuretic action of triamterene in man. Br Med J II:1362–1366Google Scholar
  94. Cella JA, Kagawa CM (1957) Steroidal lactones. J Am Chem Soc 79:4808–4809Google Scholar
  95. Celsus, Cornelius A (1915) Artium A. Cornelii Celsi quae supersunt. In: Marx F (ed) Liber II, XXX. Teubner, Lipsiae et BerolinaeGoogle Scholar
  96. Chappelle PM, Genaim R, Meyrier R (1972) Traitement des oedèmes aigus pulmonaires graves par des doses élevées de furosemide. Coeur Med Interne 11:135–146Google Scholar
  97. Chennavasin P, Seiwell R, Brater DC, Liang WM (1979) Pharmacodynamic analysis of the furosemide-probenecid interaction in man. Kidney Int 16:187–195PubMedGoogle Scholar
  98. Clapp JR, Robinson RR (1968) Distal sites of action of diuretic drugs in the dog nephron. Am J Physiol 215:228–235PubMedGoogle Scholar
  99. Clapp JR, Nottebohm GA, Robinson RR (1971) Proximal site of action of ethacrynic acid: Importance of filtration rate. Am J Physiol 220:1355–1360PubMedGoogle Scholar
  100. Clark E (1965) Spironolactone therapy and gynecomastia. JAMA 193:163–164PubMedGoogle Scholar
  101. Clement DL (1982) Effect of spironolactone on systemic blood pressure, limb blood flow and response to sympathetic stimulation in hypertensive patients. Eur J Clin Pharmacol 21:263–267PubMedGoogle Scholar
  102. Coe FL (1977) Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria, or no metabolic disorder. Ann Intern Med 87:404–410PubMedGoogle Scholar
  103. Cohanim M, Yendt ER (1976) Reduction in urine oxalate excretion during chronic thiazide therapy. Clin Sci 24:685 (Abstr)Google Scholar
  104. Cohen E (1963) Quinazolone sulfonamides, Preparation of new diuretics. Arzneimittelforsch 13:660–661PubMedGoogle Scholar
  105. Cohen E, Klarberg B, Vaughan JR (1960) Quinazolinone sulphonamides as diuretic agents. J Am Chem Soc 82:2731–2732Google Scholar
  106. Conn JW (1965) Hypertension, the potassium ion and impaired carbohydrate tolerance. N Engl J Med 273:1135–1143PubMedGoogle Scholar
  107. Cooke CR, Brown TC, Zacherle JB, Walker WG (1970) The effect of altered sodium concentration in the distal nephron segments on renin release. J Clin Invest 49:1630–1638PubMedGoogle Scholar
  108. Coppage WS Jr, Liddle GW (1960) Mode of action and clinical usefulness of aldosterone antagonists. Ann NY Acad Sci 88:815–821PubMedGoogle Scholar
  109. Corcino J, Waxman S, Herbert V (1970) Mechanism of triamterene induced megaloblastosis. Ann Intern Med 73:419–424PubMedGoogle Scholar
  110. Corcoran AC, Macleod C, Dustan HP, Page IH (1959) Effect of chlorothiazide on specific renal functions in hypertension. Circulation 19:355–359PubMedGoogle Scholar
  111. Cornish AL, MacClellan JT, Johnston DH (1961) Effects of chlorothiazide on pancreas. N Engl J Med 265:673–675PubMedGoogle Scholar
  112. Corsini WA, Hook JB, Bailie MD (1975) Control of renin secretion in the dog: Effects of furosemide on the vascular and macula densa receptors. Circ Res 37:464–470PubMedGoogle Scholar
  113. Costanzo LS, Weiner IM (1974) On the hypocalciuric action of chlorothiazide. J Clin Invest 54:628–637PubMedGoogle Scholar
  114. Costanzo LS, Weiner IM (1976) Relationship between clearances of Ca and Na: Effect of distal diuretics and PTH. Am J Physiol 230:67–73PubMedGoogle Scholar
  115. Costanzo LS, Windhager EE (1978) Calcium and sodium transport by the distal convoluted tubule of the rat. Am J Physiol 235:F492–F506PubMedGoogle Scholar
  116. Counihan TB, Evans BM, Milne MD (1954) Observations on the pharmacology of the carbonic anhydrase inhibitor “Diamox”. Clin Sci 13:583–589PubMedGoogle Scholar
  117. Cox JR, Horrocks P, Speight CJ, Pearson RE, Hobson N (1971) Potassium and sodium distribution in cardiac failure. Clin Sci 41:55–61PubMedGoogle Scholar
  118. Crabbé J (1968) A hypothesis concerning the mode of action of amiloride and of triamterene. Arch Int Pharmacodyn Ther 173:474–477PubMedGoogle Scholar
  119. Crexellis C, Chatterjee K, Forrester JS, Dikshit K, Swan HCJ (1973) Optimal level of filling pressure in the left side of the heart in acute myocardial infarction. N Engl J Med 289:1263–1266Google Scholar
  120. Crosley AP Jr (1965) The pharmacologic actions of triamterene. In: Brest AN, Moyer JH (eds) Cardiovascular drug therapy. Grune & Stratton, New York, p 184Google Scholar
  121. Crosley AP Jr, Cullen RC, White D, Freeman JF, Castillo CA, Rowe GG (1960) Studies on the mechanism of action of chlorothiazide in cardiac and renal diseases. I. Acute effects on renal and systemic hemodynamics and metabolism. J Lab Clin Med 55:182–190PubMedGoogle Scholar
  122. Crosley AP, Ronquillo L, Alexander F (1961) Studies of a nonsteroidal aldosterone antagonist (SKF 8542) in man. Fed Proc 20:410Google Scholar
  123. Crosley AP, Ronguillo LM, Strickland WH, Alexander F (1962) Triamterene, a new natriuretic agent. Preliminary observations in man. Ann Intern Med 56:241–251PubMedGoogle Scholar
  124. Croxson MS, Neutze JM, John MB (1972) Exchangeable potassium in heart disease: long term effects of potassium supplements and amiloride. Am Heart J 84:53–60PubMedGoogle Scholar
  125. Cummings JR, Rousberg MA, Stockey EA, Gussin RG (1968) Pharmacodynamics of 4-(ααα-trifluoro-m-toluidino)-nicotinic acid, a diuretic with high ceiling activity. Pharmacologist 10:162–166Google Scholar
  126. Davidson RM, Goldman J, Whalen RE (1971) Hemodynamic effects of furosemide in acute myocardial infarction. Circulation [Suppl 2] 44:156Google Scholar
  127. Davies DL, Lant A, Millard AF, Smith NR, Ward JW, Wilson GM (1974) Renal action, therapeutic use, and pharmakokinetics of the diuretic bumetanide. Clin Pharmacol Ther 15:141–155PubMedGoogle Scholar
  128. Davis JO (1971) Review: What signals the kidney to release renin? Circ Res 28:301–306PubMedGoogle Scholar
  129. Davis JO (1973) The control of renin release. Am J Med 55:333–350Google Scholar
  130. Davis JO, Carpenter CCJ, Ayers CR, Holman JE, Bahn RC (1961) Evidence for secretion of an aldosterone-stimulating hormone by the kidney. J Clin Invest 40:684–696PubMedGoogle Scholar
  131. Davis JO, Hartroft PM, Titus EO, Carpenter CCJ, Ayers CR, Spiegel HE (1962) The role of the renin-angiotensin system in the control of aldosterone secretin. J Clin Invest 41:378–389PubMedGoogle Scholar
  132. Deetjen P (1966) Micropuncture studies on site and mode of diuretic action of furosemide. Ann NY Acad Sci 139:408–415Google Scholar
  133. Deetjen P (1980) Die Wirkungsweise diuretischer Substanzen in Abhängigkeit von ihrer renalen Behandlung. In : Krück F, Schrey A (Hrsg) Diuretika. Springer, Berlin Heidelberg New York, S 35–41Google Scholar
  134. Deetjen P, Buntig WE, Hardt K, Rohde R (1969) Direct effect of ethacrynic acid in the rat: a micropuncture study concerning the relationship of site and mode of diuretic action. In: Peters G, Roch-Ramel F (eds) Progress in nephrology. Springer, Berlin Heidelberg New York, pp 255–261Google Scholar
  135. Demartini FE, Wheaton EA, Healey LA, Laragh JH (1962) Effect of chlorothiazide on the renal excretion of uric acid. Am J Med 32:572–577Google Scholar
  136. Demartini FE, Briscoe AM, Ragan C (1967) Effect of ethacrynic acid on calcium and magnesium excretion. Proc Soc Exp Biol Med 124:320–324Google Scholar
  137. Dettli L, Spring P (1960) Vergleichende pharmakologische Prüfung eines neuen Salidiureticums (Cyclopenthiazid) am gesunden Menschen. Z Ges Exp Med 134:310–322Google Scholar
  138. Dikshit K, Vyden JD, Forrester JS, Swan HJC (1973) Renal and extrarenal hemodynamic effects of furosemide in congestive heart failure after acute myocardial infarction. N Engl J Med 288:1087–1090PubMedGoogle Scholar
  139. Dirks JH, Seely JF (1969) Micropuncture and diuretics. Am Rev Pharmacol 9:73–84Google Scholar
  140. Dirks JH, Cirksena WJ, Berliner RW (1965) The effect of saline infusion on sodium reabsorption by the proximal tubule of the dog. J Clin Invest 44:1160–1170PubMedGoogle Scholar
  141. Dirks JH, Cirksena WJ, Berliner RW (1966) Micropuncture study of the effect of various diuretics on sodium reabsorption by the proximal tubules of the dog. J Clin Invest 45:1875–1885PubMedGoogle Scholar
  142. Dörge A, Nagel W (1970) Effect of amiloride on sodium transport in frog skin. II. Sodium transport pool and unidirectional fluxes. Pfluegers Arch 321:91–101Google Scholar
  143. Dollery CT, Pentecost BL, Samaan NA (1962) Drug-induced diabetes. Lancet 11:735–737Google Scholar
  144. Donnelly RJ, Turner P, Sowry GSC (1962) Clinical trial of new oral diuretic — SK & F 8542. Lancet I:245–247Google Scholar
  145. Doucet A, Katz AI (1982) Short-term effect of aldosterone on Na-K-ATPase in single nephron segments. Am J Physiol 241 : F273–F278Google Scholar
  146. Duarte CG (1968) Effects of ethacrynic acid and furosemide on urinary calcium phosphate and magnesium. Metabolism 17:867–876PubMedGoogle Scholar
  147. Duarte CG, Bland JH (1965) Calcium phosphorus and uric acid clearances after intravenous administration of chlorothiazide. Metabolism 14:211–219PubMedGoogle Scholar
  148. Duarte CG, Chomety F, Giebisch G (1971a) Effect of amiloride, ouabain and furosemide on distal tubular function in the rat. Am J Physiol 221:632–639Google Scholar
  149. Duarte CG, Winnacker JL, Becker KL, Pace A (1971b) Thiazide induced hypercalcemia. N Engl J Med 284:828–830Google Scholar
  150. Duchin KL, Burke TJ (1976) Effect of furosemide on renal autoregulation. Kidney Int 10:581 (Abstr)Google Scholar
  151. Duchin KL, Peterson LN, Burke FJ (1977) Effect of furosemide on renal autoregulation. Kidney Int 12:379–386PubMedGoogle Scholar
  152. Düsing R, Kramer HJ (1978) Prostaglandins and renal sodium excretion. In: Lee JB (ed) Renal prostaglandins. Eden Press, Montreal, pp 92–107Google Scholar
  153. Düsing R, Bartter FC, Gill JR Jr, Harrison L, Bhathena SJ, Recant L, Kramer HJ (1980a) Experimentelle Hypokaliämie beim Menschen. Klin Wochenschr 58:881–887Google Scholar
  154. Düsing R, Kipnowski J, Kramer HJ (1980b) Effect of diuretics on urinary electrolyte excretion in healthy subjects and in patients with essential hypertension: Role of renal prostaglandins. In: Zumkley H, Losse H (eds) Intracellular elektrolytes and arterial hypertension. Thieme, Stuttgart New York, pp 250–262Google Scholar
  155. Düsing R, Harrison LC, Bhathena S, Recant L, Bartter FC (1981) Impairment of insulin secretion during experimental potassium depletion is not corrected by the prostaglandin synthesis inhibitor, indomethacin. Clin Endocrinol 15:567–572Google Scholar
  156. Duggan DE (1966) The accumulation of chlorothiazide and related saluretic agents by isolated renal tubules. J Pharmacol Exp Ther 152:122–129PubMedGoogle Scholar
  157. Duggan DE, Noll RM (1965) Effects of ethacrynic acid and cardiac glycosides upon a membrane adenosine-triphosphatase of renal cortex. Arch Biochem Biophys 109:388–396Google Scholar
  158. Duke M (1978) Thiazide-induced hypokalemia: association with acute myocardial infarction and ventricular fibrillation. JAMA 239:43–45PubMedGoogle Scholar
  159. Dunn MJ, Zambraski EJ (1980) Renal effects of drugs that inhibit prostaglandin synthesis. Kidney Int 18:609–622PubMedGoogle Scholar
  160. Dustan HR, Tarazi RC, Bravo EL (1974) Diuretic and diet treatment of hypertension. Arch Intern Med 133:1007–1013PubMedGoogle Scholar
  161. Earley LE, Friedler RM (1964) Diuretic action of ethacrynic acid in congestive heart failure. J Clin Invest 43:1495–1506PubMedGoogle Scholar
  162. Earley LE, Martino JA (1970) Influence of sodium balance on the ability of diuretics to inhibit tubular reabsorption. Circulation 42:323–334PubMedGoogle Scholar
  163. Earley LE, Orloff J (1962) The mechanism of antidiuresis associated with the administration of hydrochlorothiazide to patients with vasopressin-resistant diabetes insipidus. J Clin Invest 41:1988–1997PubMedGoogle Scholar
  164. Earley LE, Orloff J (1964) Thiazide diuretics. Annu Rev Med 15:149–166PubMedGoogle Scholar
  165. Earley LE, Kahn M, Orloff J (1961) The effects of infusions of chlorothiazide on urinary dilution and concentration in the dog. J Clin Invest 40:857–866PubMedGoogle Scholar
  166. Edmondson RPS, Thomas RD, Hilton JP, Patrick J (1974) Leucocyte electrolytes in cardiac and non-cardiac patients receiving diuretics. Lancet I:12–14Google Scholar
  167. Edwards BR, Baer PG, Sutton RAL, Dirks JH (1973) Micropuncture study of diuretic effects on sodium and calcium reabsorption in the dog nephron. J Clin Invest 52:2418–2427PubMedGoogle Scholar
  168. Eide I, Løyning EW, Kiil F (1973) Evidence for hemodynamic autoregulation of renin release. Circ Res 32:237–245PubMedGoogle Scholar
  169. Eide I, Løyning E, Langård Ø, Kiil F (1975) Influence of ethacrynic acid on intrarenal renin release mechanisms. Kidney Int 8:158–165PubMedGoogle Scholar
  170. Eknoyan G, Suki WN, Martinez-Maldonado M (1970) Effect of diuretics on urinary excretion of phosphate, calcium, and magnesiun in thyroparathyroidectomized dogs. J Lab Clin Med 76:257–266PubMedGoogle Scholar
  171. Elliott HC (1962) Reduced adrenocortical steroid excretion rates in man following aspirin administration. Metabolism 11:1015–1018Google Scholar
  172. Ellis PA (1961) Renal enlargement in chronic cor pulmonale. J Clin Pathol 14:552–556PubMedGoogle Scholar
  173. Enson Y, Giuntini C, Lewis ML, Morris TQ, Ferrer MI, Harvey RM (1964) The influence of hydrogen ion concentration and hypoxia on the pulmonary circulation. J Clin Invest 43:1146–1162PubMedGoogle Scholar
  174. Erbler H (1973) Selective inhibition of aldosterone synthesis by 11-hydroxylated spirolactone in rat adrenals. Naunyn Schmiedebergs Arch Pharmacol 280:331–337PubMedGoogle Scholar
  175. Erbler HC (1974) The effect of saluretics and spironolactone on aldosterone production and electrolyte excretion in man. Naunyn Schmiedebergs Arch Pharmacol 286:145–156PubMedGoogle Scholar
  176. Erdmann E, Krawietz W (1976) On the action of triamteren on isolated cell membranes. Arzneimittelforsch 26:1812–1817PubMedGoogle Scholar
  177. Evanson RL, Lockhart EA, Dirks JH (1972) Effect of mercurial diuretics on tubular sodium and potassium transport in the dog. Am J Physiol 222:282–289PubMedGoogle Scholar
  178. Fauchald P, Lind E (1977) Double-blind crossover study on the diuretic effect of Bay g 2821 and furosemide in patients with cardiac edema. Pharmacotherapeutica 1:409–414Google Scholar
  179. Feigen LP, Klainer E, Chapnik BM, Kadowitz PJ (1976) The effect of indomethacin on renal function in pentobarbital anesthetized dogs. J Pharmacol Exp Ther 198:457–463PubMedGoogle Scholar
  180. Fernandez PC, Puschett JB (1973) Proximal tubular actions of metolazone and chlorothiazide. Am J Physiol 225:954–961PubMedGoogle Scholar
  181. Fine SL, Levy RI (1965) Ethacrynic acid in acute pulmonary edema. N Engl J Med 273:583–586PubMedGoogle Scholar
  182. Fichman MP, Vorherr H, Kleeman CR, Telfer N (1971) Diuretic induced hyponatremia. Ann Intern Med 75:853–863PubMedGoogle Scholar
  183. Flear CTG, Quinton A, Carpenter RG, Domenet JG, Silver A (1966) Exchangeable body potassium and sodium in patients with congestive heart failure. Clin Chim Acta 13:1–12PubMedGoogle Scholar
  184. Flower RJ (1974) Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev 26:33–67PubMedGoogle Scholar
  185. Fonseca V, Phear DN (1982) Hyperosmolar non-ketotic diabetic Syndrome precipitated by treatment with diuretics. Br Med J 284:36–37Google Scholar
  186. Ford RV (1958) Diuretic therapy in congestive heart failure. Ann NY Acad Sci 71:397–408PubMedGoogle Scholar
  187. Ford RV (1960) The clinical pharmacologic investigation of a new benzothiadiazine diuretic, CMR-807. Am J Cardiol 5:407–412PubMedGoogle Scholar
  188. Forrester JS, Waters DD (1978) Hospital treatment of congestive heart failure. Management according to hemodynamic profile. Am J Med 65:173–180PubMedGoogle Scholar
  189. Forrester JS, Diamond GA, Swan HJC (1977) Correlative classification of clinical and hemodynamic function after acute myocardial infarction. Am J Cardiol 39:137–145PubMedGoogle Scholar
  190. Fraser R, James VHT, Brown JJ, Isaac P, Lever AF, Robertson JLS (1965) Effect of angiotensin and of furosemide on plasma aldosterone, corticosterone, cortisol and renin in man. Lancet II:989–991Google Scholar
  191. Friedberg CK, Taymor R, Minor JB, Halpern M (1953) The use of diamox, a carbonic anhydrase inhibitor, as an oral diuretic in patients with congestive heart failure. N Engl J Med 248:883–889PubMedGoogle Scholar
  192. Friedman PA, Roche-Ramel F (1977) Hemodynamic and natriuretic effects of bumetanide and furosemide in the cat. J Pharmacol Exp Ther 203:82–91PubMedGoogle Scholar
  193. Frölich JC, Hollifield JW, Dormois JC, Seyberth HI, Michelakis AM, Oates JA (1976) Suppression of plasma renin activity by indomethacin in man. Circ Res 39:447–452PubMedGoogle Scholar
  194. Frömter E (1974) Electrophysiology and isotonic fluid absorption of proximal tubules of mammalian kidney. In: Thurau K (ed) Physiology, series I, vol 6. University Park Press, Baltimore, pp 1–38Google Scholar
  195. Fuisz RE, Lauler DP, Cohen P (1962) Diuretic induced hyponatremia and sustained antidiuresis. Am J Med 33:783–791PubMedGoogle Scholar
  196. Gantt CL (1962) Observations on the mechanism of action of steroidal spirolactones. Metabolism 11:1061–1063PubMedGoogle Scholar
  197. Gantt CL, Ecklund RE (1962) Significance of aldosterone antagonism in the treatment of edema and ascites. Am J Med 33:490–500PubMedGoogle Scholar
  198. Gasch J, Krück F (1953) Die Diurèse unter Carboanhydrase-Hemmung. Klin Wochenschr 31:285PubMedGoogle Scholar
  199. Gatzky JT (1971) The effect of K+-sparing diuretics on ion transport across the excised toad bladder. J Pharmacol Exp Ther 176:580–594Google Scholar
  200. Gauer OH, Henry JP (1963) Circulatory basis of fluid volume control. Physiol Rev 43:423–482PubMedGoogle Scholar
  201. Genest J, Granger P, de Champlain J, Boucher R (1968) Endocrine factors in congestive heart failure. Am J Cardiol 22:35–42PubMedGoogle Scholar
  202. Gerber JG, Nies AS (1980) Furosemide-induced vasodilatation: Importance of the state of hydration and filtration. Kidney Int 18:454–459PubMedGoogle Scholar
  203. Gerber IG, Branch RA, Nies AS, Hollifield JW, Gerkens JF (1979) Influence of hypertonic saline on canine blood flow and renin release. Am J Physiol 237 : F441–F446Google Scholar
  204. Gerich JE, Martin MM, Recant L (1971) Clinical and metabolic characteristics of hyperosmolar nonketotic coma. Diabetes 20:220–229Google Scholar
  205. Gibson H, Harris P (1970) Effects of diuretics on microsomal (Na+, K+) ATPase in the human heart and the rat heart and kidney. Cardiovasc Res 4:343–347PubMedGoogle Scholar
  206. Giebisch G (1976) Effects of diuretics on renal transport of potassium. In: Martinez-Maldonado M (ed) Methods in pharmacology, vol 4A. Plenum, New York, pp 121–164Google Scholar
  207. Giebisch G, Stanton B (1979) Potassium transport in the nephron. Annu Rev Physiol 41:241–256PubMedGoogle Scholar
  208. Glitzer MS, Steelman SL (1966) N-Amidino-,3,5-diamino-6-chloropyrazine-carboxamide. An active diuretic in the carboxamide series. Nature 212:191–193PubMedGoogle Scholar
  209. Glück Z, Baumgartner G, Weidmann P, Peheim E, Bachmann C, Mordasini R, Flammer J, Keusch G (1978) Increased ratio between β- and α-lipoproteins during diuretic therapy: an adverse effect? Clin Sci Mol Med 55:325S–328SGoogle Scholar
  210. Glück Z, Weidmann P, Mordasini R, Bachmann C, Riesen W, Peheim E, Keusch G, Meier A (1980) Increased serum low-density-lipoprotein cholesterol in men treated short-term with the diuretic chlorthalidone. Metabolism 29:240–245PubMedGoogle Scholar
  211. Gochman N, Gantt CL (1962) A fluorimetric method for the determination of a major spironolactone (Aldactone) metabolite in human plasma. J Pharmacol Exp Ther 135:312–316PubMedGoogle Scholar
  212. Goetz KL, Hermreck AS, Slick GL, Starke HS (1970) Atrial receptors and renal function in conscious dogs. Am J Physiol 219:1417–1423PubMedGoogle Scholar
  213. Goldberg M (1966) Ethacrynic acid: Site and mode of action. Ann NY Acad Sci 139:443–452PubMedGoogle Scholar
  214. Goldberg M (1973) The renal physiology of diuretics. In: Orloff J, Berliner RW (eds) Handbook of physiology. American Physiological Society Washington, pp 1003–1031Google Scholar
  215. Goldberg M, Mc Curdy DK, Foltz EL, Bluemle LW (1964) Effects of ethacrynic acid (a new saluretic agent) on renal diluting and concentrating mechanisms: Evidence for site of action in the loop of Henle. J Clin Invest 43:201–216PubMedGoogle Scholar
  216. Goldman A, Stelle B, Schnaper H, Fitz A, Fröhlich E, Perry HM (1980) Serum lipoprotein levels during chlorthalidone therapy. JAMA 244:1691–1695PubMedGoogle Scholar
  217. Goldner MG, Zarowitz H, Akgun S (1960) Hyperglycemia and glycosuria due to thiazide derivatives administered in diabetes mellitus. N Engl J Med 262:403–405PubMedGoogle Scholar
  218. Gombos EA, Freis ED, Moghadam A (1967) Effects of MK 870 in normal subjects and hypertensive patients. N Engl J Med 275:1215–1220Google Scholar
  219. Graf W, Girod E, Schmid E, Stoll WG (1959) Zur Konstitution von Benzophenon-2-Carbonsäure-Derivaten. Helv Chim Acta 42:1085–1087Google Scholar
  220. Grant AM, Wolff FW (1969) The hyperglycemie activity of triamterene. Pharmacol Res Commun 1:224–230Google Scholar
  221. Grantham J, Burg MB, Orloff J (1970) The nature of transtubular Na+ and K+ transport in isolated renal collecting tubules. J Clin Invest 49:1815–1827PubMedGoogle Scholar
  222. Greeff K, Köhler E (1975) Tierexperimentelle Untersuchungen über den Einfluß von Triamteren und Amiloid auf Herz, Kreislauf und die Toxizität des Digoxins. Arzneimittelforsch 25:1766–1769PubMedGoogle Scholar
  223. Greven J, Defrain W, Glaser K, Meywald K, Heidenreich O (1980) Studies with the optically active isomers of the new diuretic drug ozolinone: I. Diffrences in stereoselectivity of the renal target structures of ozolinone. Pfluegers Arch 384:57–60Google Scholar
  224. Grimm RH, Leon AS, Hunninghake DB, Lenz K, Hannan P, Blackburn H (1981) Effects of thiazide diuretics on plasma lipids and lipoproteins in mildly hypertensive patients. A double-blind controlled trial. Ann Intern Med 94:7–11PubMedGoogle Scholar
  225. Guidoux R (1969) Effects diabétogénes des diuretiques thiazidiques et du solvant Nmonométhylamide de l’acide acétique chez le rat. Diabetologia 5:11–21PubMedGoogle Scholar
  226. Gussin RG, Cummings JR, Stockey EA, Rousberg MA (1969) (4-(ααα-trifluoro-m-toluidino)-nicotinic acid. A novel “high ceiling” diuretic. J Pharmacol Exp Ther 167:194–198PubMedGoogle Scholar
  227. Hänze S, Seyberth H (1967) Untersuchungen zur Wirkung der Diuretika Furosemid, Etacrynsäure und Triamteren auf die renale Magnesium- und Calciumausscheidung. Klin Wochenschr 45:313–314PubMedGoogle Scholar
  228. Häussier A, Hajdu P (1964) Untersuchungen mit dem Salidiureticum 4-Chlor-N-(Furylmethyl)-5-Sulfamyl-Anthranilsäure. Arzneimittelforsch 14:713–716Google Scholar
  229. Hantman D, Rossier B, Zohlman R, Schrier R (1973) Rapid correction of hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone. Ann Intern Med 78:870–875PubMedGoogle Scholar
  230. Hanzelik E, Peppercorn M (1969) Deafness after ethacrynic acid. Lancet I:416Google Scholar
  231. Hänze S (1960) Untersuchungen zur Wirkung verschiedener Diuretica auf die renale Magnesium- und Calcium-Ausscheidung. Klin Wochenschr 38:1168Google Scholar
  232. Harris AS, Bisteni A, Russell RA, Brigham JC, Firestone JE (1954) Excitatory factors in ventricular tachycardia resulting from myocardial ischemia potassium a major excitant. Science 119:200–203PubMedGoogle Scholar
  233. Harrison JE, Hitchman JW, Finlay JM, Fraser D, Yendt ER, Bayley TA, Mc Neil KG (1971) Effect of treatment on calcium kinetic in metabolic bone disease. Metabolism 20:1107–1118PubMedGoogle Scholar
  234. Healey LA, Magid GJ, Decker JL (1959) Uric acid retention due to hydrochlorothiazide. N Engl J Med 261:1358–1362PubMedGoogle Scholar
  235. Healy JJ, Mc Kenna TJ, Canning B, Brien TG, Duffy GJ, Muldowney FP (1970) Body composition changes in hypertensive subjects on long-term oral diuretic therapy. Br Med J I:716–719Google Scholar
  236. Heidenreich O, Gharemani G, Keller P, Kook Y, Schmiz K (1964) Die Wirkungen von 2-Carbäthoxymethylen-3-methyl-5-N-piperidino-thiazolidon-4 auf Nierenfunktion von Ratten und Hunden. Arzneimittelforsch 14:1242–1248PubMedGoogle Scholar
  237. Heidland A, Klütsch K, Schneider KW, Suzuki F (1964) Thiaziddiuretika und Nierenfunktion bei Hypertonie und kardialer Dekompensation. Klin Wochenschr 42:831–833Google Scholar
  238. Heidland A, Klütsch K, Moormann A (1967) Zur renalen Kalium-Retention nach Verabreichung von Amiloride HCl. Arzneimittelforsch 10:1314–1318Google Scholar
  239. Heimsoth V, Hartmann F (1965) Klinische Bewertung der Kohlenhydratstoffwechselstörungen durch Saluretika. Dtsch Med Wochenschr 90:1467–1473PubMedGoogle Scholar
  240. Heinemann HO (1978) Right-sided heart failure and the use of diuretics. Am J Med 64:367–370PubMedGoogle Scholar
  241. Heinemann HO, Demartini FE, Laragh JH (1959) The effect of chlorothiazide on renal excretion of electrolytes and free water. Am J Med 26:853–861PubMedGoogle Scholar
  242. Hempelmann FW (1975a) Die Proteinbindung von Xipamid (4-Chlor-5-sulfamoyl-2′,6′-salicyloxylidid). Arzneimittelforsch 25:258–259Google Scholar
  243. Hempelmann FW (1975b) Die Hemmung der Carboanhydrase durch Xipamid (4-Chlor-5-sulfamoyl-2′,6′-salicyloxylidid) im modifizierten Philpot-Test. Arzneimittelforsch 25:259–260Google Scholar
  244. Hempelmann FW, Leuschner F, Liebenow W (1975) Die saluretische Wirkung von Xipamid (4-Chlor-5-sulfamoyl-2′,6′-salicyloxylidid) bei gesunden Probanden. Arzneimittelforsch 25:252–255PubMedGoogle Scholar
  245. Henry JP, Gauer OH, Reeves JL (1956) Evidence of atrial location of receptors influencing urine flow. Circ Res 4:85–94PubMedGoogle Scholar
  246. Hierholzer K, Wiederholt W, Holzgreve H, Giebisch G, Klose RM, Windhager EE (1965) Micropuncture study of renal transtubular concentrations gradients of sodium and potassium in adrenalectomised rats. Pfluegers Arch 285:193–210Google Scholar
  247. Higgins BA, Nassim JR, Collins J, Hilb A (1964) The effect of bendrofluazide on urine calcium excretion. Clin Sci 27:457–462PubMedGoogle Scholar
  248. Higgins JT, Frömter E (1974) Potential profile in necturus urinary bladder. Pfluegers Arch 347:R32Google Scholar
  249. Hild R, Krück F (1961) Die aldosteron-antagonistischen Spirolactone. II. Klinik. Klin Wochenschr 39:178–181PubMedGoogle Scholar
  250. Hoffmeister W, Krück F (1956) Die Bedeutung der Acidose bei der Carboanhydrase-Hemmungsdiurese. Klin Wochenschr 34:394–399PubMedGoogle Scholar
  251. Hoffmeister W, Krück F (1957a) Die Diurèse durch Carboanhydrasehemmung. Problematik der klinischen Anwendung. I. Teil. Aerztl Wochenschr 12:49–57Google Scholar
  252. Hoffmeister W, Krück F (1957b) Die Diurèse durch Carboanhydrasehemmung. Problematik der klinischen Anwendung, II. Teil. Aerztl Wochenschr 12:81–89Google Scholar
  253. Hofmann LM, Krupnick MI (1972) Interactions of spironolactone an hydrochlorothiazide with aspirin in the rat and dog. J Pharmacol Exp Ther 180:1–5PubMedGoogle Scholar
  254. Hohenegger M (1973) Potassium-escape-phenomenon in rats during continuous application of amiloride. IV. Etiology of the excape phenomenon. Pharmacology 9:27–34PubMedGoogle Scholar
  255. Holland OB, Nixon JV, von Kuhnert L (1981) Diuretic-induced ventricular ectopic activity. JAMA 70:762–768Google Scholar
  256. Holzgreve H (1973) Diuretika. In: Kuemmerle HP, Goossens N (Hrsg) Klinik und Therapie der Nebenwirkungen. Thieme, Stuttgart, S 707–732Google Scholar
  257. Homeida M, Roberts C, Branch RA (1977) Influence of probenecid and spironolactone on furosemide kinetics and dynamics in man. Clin Pharmacol Ther 22:402–409PubMedGoogle Scholar
  258. Homer MJ (1971) Deafness after ethacrynic acid. N Engl J Med 285:1152PubMedGoogle Scholar
  259. Hook JB, Williamson HE (1965a) Effect of furosemide on renal medullary sodium gradient. Proc Soc Exp Biol Med 118:372–374Google Scholar
  260. Hook JB, Williamson HE (1965b) Influence of probenecid and alterations on acid-base balance of the saluretic activity of furosemide. J Pharmacol Exp Ther 149:404–408Google Scholar
  261. Hook JB, Blatt AH, Brody MJ, Williamson HE (1966) Effect of several saluretic-diuretic agents on renal hemodynamics. J Pharmacol Exp Ther 154:667–673PubMedGoogle Scholar
  262. Horowitz J, Keynan A, Ben Ishay D (1972) A syndrome of inappropriate ADH secretion induced by cyclothiazide. J Clin Pharmacol 12:337–341Google Scholar
  263. Hull AR, Suki WN, Rector FC jr, Seidin DW (1967) Mechanism of diuretic-induced hyperuricemia. Proc Am Soc Nephrol 31 (Abstr)Google Scholar
  264. Hummerich W, Krause DK, Konrads A, Kaufmann W (1980) Die Bedeutung von Volumenfaktoren und neuralen Mechanismen bei der Reninfreisetzung nach Furosemid und Etacrynsäure. In: Krück F, Schrey A (Hrsg) Diuretika. Springer, Berlin Heidelberg New York, S 123–132Google Scholar
  265. Ikram H, Chan W, Espiner EA, Nicholls MG (1980) Haemodynamic and hormone responses to acute and chronic frusemide therapy in congestive heart failure. Clin Sci 59:443–449PubMedGoogle Scholar
  266. Imbs JL, Velly J, Fontaine JL, Schwartz J (1970) Contrôle de la sećrétion de rénine. Nephron 7:499–511PubMedGoogle Scholar
  267. Imbs JL, Desaulles E, Velly J, Block R, Schwartz J (1972) Action du dopamide et de l’acide ethacrynique sur la sécrétion de rénine chez le chien. Pfluegers Arch 331:294–306Google Scholar
  268. Imbs JL, Schmidt M, Velly J, Schwartz J (1977) Comparison of the effect of two groups of diuretics on renin secretion in the anesthetized dog. Clin Sci Mol Med 52:171–172PubMedGoogle Scholar
  269. Jacobsen HR, Kokko JP (1976) Diuretics: Sites and mechanism of action. Annu Rev Pharmacol Toxicol 16:201–214Google Scholar
  270. Jahnecke J (1967) Hochdruck, Saluretika und Glucosetoleranz. Dtsch Med Wochenschr 92:1270–1278PubMedGoogle Scholar
  271. Jahnecke J, Konietzko H, Krück F (1964) Kliniche Pharmakologie des Furosemid im akuten Versuch. Verh Dtsch Ges Inn Med 70:1001–1004PubMedGoogle Scholar
  272. Johnson JA, Moore WW, Segar WE (1969) Small changes in left atrial pressure and plasma antidiuretic hormone titers in dogs. Am J Physiol 217:210–214PubMedGoogle Scholar
  273. Joos C, Kewitz H, Reinhold-Kourniati D (1980) Effects of diuretics on plasma lipoproteins in healthy men. Eur J Clin Pharmacol 17:251–257PubMedGoogle Scholar
  274. Jørgensen FS (1971) The effect of bendroflumethiazide (centyl) on the renal excretion of calcium and sodium in normal, parathyroidectomized, thyroidectomized and thyroparathyroidectomized rats. Acta Pharmacol Toxicol 30:296–307Google Scholar
  275. Jørgensen FS, Nielsen SP (1972) Effects of long term administration of bendroflumethiazide on bone metabolism in the rat. Acta Pharmacol Toxicol 31:521–528Google Scholar
  276. Jørgensen FS, Transbol I, Binder C (1973) The effect of bendroflumethiazide on total, ultrafiltrable and ionized calcium in serum in normocalcemic renal stone fromers and hyperparathyroidims. Acta Med Scand 194:323–326PubMedGoogle Scholar
  277. Kaess H, Schlierf G, Ehlers W, Mikulicz-Radecki JG von, Hassenstein P, Walter K, Brecht W, Hengstmann J (1971) The carbohydrate metabolism of normal subjects during potassium depletion. Diabetologia 7:82–86PubMedGoogle Scholar
  278. Kagawa CM, Jacobs RS (1959) Action of testosteron in blocking urinary effects of desoxycorticosterone. Proc Soc Exp Biol Med 102:521–523PubMedGoogle Scholar
  279. Kagawa CM, Cella JM, Arman CG van (1957) Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science 126:1015–1021PubMedGoogle Scholar
  280. Kagawa CM, Sturtevant FM, Arman CG (1959) Pharmacology of a new steroid that blocks salt activity of aldosterone and desoxycorticosterone. J Pharmacol Exp Ther 126:123–130PubMedGoogle Scholar
  281. Kassirer JP, Harrington JT (1977) Diuretics and potassium metabolism: A reassessment of the need, effectiveness and safety of potassium therapy. Kidney Int 11:505–515PubMedGoogle Scholar
  282. Keeler R (1974) Natriuresis after unilateral stimulation of carotid receptors in unanesthetized rats. Am J Physiol 226:507–511PubMedGoogle Scholar
  283. Kempner W (1948) Treatment of hypertensive vascular disease with rice diet. Am J Med 4:545–577PubMedGoogle Scholar
  284. Kennedy RM, Earley LE (1970) Profound hyponatremia resulting from a thiazide-induced decrease in urinary diluting capacity in a patient with primary polydipsia. N Engl J Med 202:1185–1186Google Scholar
  285. Khaleeli AA, Wyman AL (1978) Hyperosmolar non-ketotic coma induced by frusemide in modest dosage. Postgrad Med J 54:43–44PubMedGoogle Scholar
  286. Kiely JD, Kelly T, Taylor DR, Pitt B (1973) The role of furosemide in the treatment of left ventricular dysfunction associated acute myocardial infarction. Circulation 48:581–587PubMedGoogle Scholar
  287. Kiil F (1975) Influence of autoregulation on renin release and sodium excretion. Kidney Int [Suppl 5] 8:210–218Google Scholar
  288. Kiil F, Kjekshus J, Løyning E (1969) Role of autoregulation in maintaining glomerular filtration rate at large urine flow. Acta Physiol Scand 76:24–39PubMedGoogle Scholar
  289. King CV (1957) Mercury: Its scientific history and its role in physical chemistry and electrochemistry. Ann NY Acad Sci 65:407–414Google Scholar
  290. Kiowski W, Julius S (1978) Renin response to stimulation of cardiopulmonary mechanoreceptors inman. J Clin Invest 62:656–663PubMedGoogle Scholar
  291. Kirkendall WM, Stein JH (1968) Clinical pharmacology of furosemide and ethacrynic acid. Am J Cardiol 22:162–167PubMedGoogle Scholar
  292. Kirschenbaum MA, White N, Stein JH, Ferris TH (1974) Redistribution of renal cortical blood flow during inhibition of prostaglanding synthesis. Am J Physiol 227:801–805PubMedGoogle Scholar
  293. Kleeberg UR, Belz GG (1974) Die Hemmung der Na+ — K+-Membran-ATPase und der 86Rubidiumaufnahme menschlicher Erythrocyten durch Spironolacton und seine Metaboliten. Verh Dtsch Ges Inn Med 80:1521–1523PubMedGoogle Scholar
  294. Kleeman CR, Bohannan J, Bernstein D, Ling S, Maxwell MM (1964) Effect of variations in sodium intake on calcium excretion in normal humans. Proc Soc Exp Biol Med 115:29–32PubMedGoogle Scholar
  295. Knauf H (1977) Mechanisms of action of the potassium-retaining diuretics Spironolactone, Triamterene and Amiloride. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Thieme, Stuttgart, pp 85–90Google Scholar
  296. Knauf H, Mutschier E (1980) Pharmakokinetik von Diuretika bei eingeschränkter Nierenfunktion. In: Krück F, Schrey A (Hrsg) Diuretika. Springer, Berlin Heidelberg New York, S 14–23Google Scholar
  297. Knauf H, Vais U, Lübcke R, Albiez G (1976a) On the mechanism of action of triamterene. Effects on transport of Na +, K+, and H+-/HCO3 --ions. Eur J Clin Invest 6:43–50Google Scholar
  298. Knauf H, Simon B, Wais U (1976b) Non-specific inhibition of membrane-ATPase by amiloride. Naunyn-Schmiedebergs Arch Pharmacol 292:189–192Google Scholar
  299. Knight TF, Senekjian HO, Taylor K, Steplock DA, Weinman EJ (1979) Renal transport of oxalate: Effects of diuretics, uric acid and calcium. Kidney Int 16:572–576PubMedGoogle Scholar
  300. Kochar MS (1979) Alterations in Serum lipids with antihypertensive therapy. Prev Med 8:181 (Abstr)Google Scholar
  301. Königstein RP, Mähr G (1962) Die Verwendung von Saluretika bei Diabetikern. Wien Med Wochenschr 112:82–84Google Scholar
  302. Kohner EM, Dollery CT, Lowy C, Schumer B (1971) Effect of diuretic therapy on glucose tolerance in hypertensive patients. Lancet I:986–990Google Scholar
  303. Komorn RM, Cafruny EJ (1964) Ethacrynic acid: diuretic property coupled to reaction with sulfhydryl groups of renal cells. Science 143:133–134PubMedGoogle Scholar
  304. Kraikitpanitsch S, Antonion LG, Lindeman RD (1976) Effects of diuretics on increased cation excretion after glucose ingestion. Kidney Int 10:571 (Abstr)Google Scholar
  305. Kramer HJ (1977) In vitro effects of Bay g 2821 on rat renal Na-K-ATPase. Pharmacotherapeutica 1:353–359Google Scholar
  306. Kramer HJ, Düsing R, Stinnesbeck B, Prior W, Bäcker A, Eden J, Kipnowski J, Glänzer K, Krück F (1980) Interaction of conventional and antikaliuretic diuretics with the renal prostaglandin system. Clin Sci 59:67–70PubMedGoogle Scholar
  307. Kramer HJ, Kipnowski J, Düsing R, Glänzer K, Klingmüller D, Krück F (1981) Wechselwirkung zwischen Diuretika und renalem Prostaglandin- und Kininsystem : Untersuchungen bei gesunden Probanden und bei Patienten mit essentieller Hypertonie. In: Krück F, Schrey A (Hrsg) Diuretika II. Wolff, München, S 184–201Google Scholar
  308. Krecke HJ, Klein H, Uhse HG, Krück F (1971) Renale Hämodynamik, Elektrolytausscheidung und Säure-Basen-Haushalt unter Etacrynsäure im akuten Versuch beim Menschen. Klin Wochenschr 49:397–405PubMedGoogle Scholar
  309. Krück F (1958) Wirkungsmechanismus und Indikationsbereich der Anionendiuretika bei oraler Verabreichung. Aerztl Wochenschr 13:1058–1064Google Scholar
  310. Krück F (1959) Klinische Untersuchungen zum Wirkungsmechanismus neuer Saluretika. Dtsch Med Wochenschr 84:1216–1220PubMedGoogle Scholar
  311. Krück F (1963a) Klinische Pharmakologie des 2,4,7-Triamino-6-Phenyl-Pteridin, einer neuartigen diuretisch wirksamen Substanz. In : Reubi F, Pauli HG (Hrsg) Das nephrotische Syndrom. Thieme, Stuttgart, S 177–181Google Scholar
  312. Krück F (1963b) Osmotische Clearance, Elektrolytausscheidung und Säure-Basenhaushalt unter der Einwirkung verschiedener Diuretika. Arzneimittelforsch 13:673–676Google Scholar
  313. Krück F (1968) Diuretika. Fortschr Med 86:354–359Google Scholar
  314. Krück F (1969) Influence of humoral factors on renal tubular sodium handling. Nephron 6:205–216PubMedGoogle Scholar
  315. Krück F (1970a) Physiological natriuretic activity in human urine. In: Cort JH, Lichardus B (eds) Regulation of body fluids by the kidney. Karger, Basel München New York Paris, pp 100–113Google Scholar
  316. Krück F (1970b) Das natriuretische Prinzip. Bedeutung und Nachweisversuche. Med Klin 65:1155–1160Google Scholar
  317. Krück F (1970c) Antikaliuretische Diuretika. Therapiewoche 20:1122–1126Google Scholar
  318. Krück F, Hild R (1960) Die aldosteron-antagonistischen Spirolactone I. Pharmakologie. Klin Wochenschr 38:962–965Google Scholar
  319. Krück F, Hild R (1961) Untersuchungen über die Wirkung von 2,4,7-Triamino-6-Phenylpteridin am Menschen. Klin Wochenschr 39:1300–1301Google Scholar
  320. Krück F, Hild R (1962) Untersuchungen zur Lokalisation des Angriffspunktes von 2,4,7-Triamino-6-Phenyl-Pteridin am Nephron. Verh Dtsch Ges Inn Med 68:685–688Google Scholar
  321. Krück F, Jahnecke J (1966) Pharmakologische Untersuchungen zur Beeinflussung der Clearance freien Wassers durch Furosemid. Klin Wochenschr 44:1355–1360PubMedGoogle Scholar
  322. Krück F, Kramer HJ (1978) Third factor and edema formation. Contrib Nephrol 13:12–20PubMedGoogle Scholar
  323. Krück F, Kroitzsch C (1961) Analyse der renalen Kaliumverluste bei Diuresetherapie durch CAH-Inhibitoren und Thiazidderivate. Klin Wochenschr 39:677–679Google Scholar
  324. Kunau RT, Weiler DR, Webb HL (1975) Clarification of the site of chlorothiazide in the rat nephron. J Clin Invest 56:401–407PubMedGoogle Scholar
  325. Lal S, Murtagh JG, Pollock AM, Fletcher E, Binnion PR (1969) Acute hemodynamic effects of furosemide in patients with normal and raised left arterial pressures. Br Heart J 31:711–717PubMedGoogle Scholar
  326. Lamberg BA, Kuhlback B (1959) Effect of chlorothiazide and hydrochlorothiazide on the excretion of calcium in urine. Scand J Clin Lab Invest 2:351–357Google Scholar
  327. Landau RL, Lugibihl K (1958) Inhibition of the sodium-retaining influence of aldosterone by progesterone. J Clin Endocrin Metab 18:1237–1245Google Scholar
  328. Landau RL, Bergenstal DM, Lugibihl K, Kascht ME (1955) The metabolic effects of progesterone in man. J Clin Endocrinol Metab 15:1194–1215PubMedGoogle Scholar
  329. Lane P (1960) Drug-induced gout. Br Med J II:1383–1384Google Scholar
  330. Lang F, Greger R, Deetjen P (1977) Effect of diuretics on uric acid metabolism and excretion. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Thieme, Stuttgart, pp 213–224Google Scholar
  331. Lant AF, Smith AJ, Wilson GM (1969) Clinical evaluation of amiloride, a potassium sparing diuretic. Clin Pharmacol Ther 10:50–63PubMedGoogle Scholar
  332. Laragh JH (1954) Effect of potassium chloride on hyponatremia. J Clin Invest 33:807–818PubMedGoogle Scholar
  333. Laragh JH (1958) Some effects of chlorothiazide on electrolyte metabolism and its use in edematous states. Ann NY Acad Sci 71:409–419PubMedGoogle Scholar
  334. Laragh JH (1962) Hormones and the pathogenesis of congestive heart failure: Vasopressin, aldosterone and angiotensin II. Further evidence for renal-adrenal interaction from studies in hypertension and in cirrhosis. Circulation 25:1015–1023PubMedGoogle Scholar
  335. Laragh JH, Heinemann HO, Demartini FE (1958) The effect of chlorothiazide on electrolyte transport in man and its use in the treatment of edema of congestive heart failure, nephrosis and cirrhosis. JAMA 166:145–153Google Scholar
  336. Laragh JH, Angers M, Kelly WG, Lieberman S (1960) The effect of epinephrine, norepinephrine, angiotensin II and others on the secretory rate of aldosterone in man. JAMA 174:234–240PubMedGoogle Scholar
  337. Laragh JH, Reilly EB, Stites TB, Angers M (1961) Pteridine compound as an inhibitor of aldosterone action in man. Fed Proc 20:410Google Scholar
  338. Laragh JH, Cannon PJ, Stason WB, Heinemann HO (1966) Physiologic and clinical observations on furosemide and ethacrynic acid. Ann NY Acad Sci 139:453–465PubMedGoogle Scholar
  339. Larson C, Weber PC, Anggard E (1974) Arachidonic acid increases and indomethacin decreases plasma renin activity in the rabbit. Eur J Pharmacol 28:391–394Google Scholar
  340. Lassen JB, Nielsen OE (1963) Investigations into the diuretic effect and elimination of triamterene. Acta Pharmacol Toxicol 20:309–316Google Scholar
  341. Lassiter WE, Gottschalk CW, Mylle M (1963) Micropuncture study of renal tubular reabsorption of calcium in normal rodents. Am J Physiol 204:771–775Google Scholar
  342. Lavender S, Mc Gill MB (1974) Non-ketotic hyperosmolar coma and frusemide therapy. Diabetes 23:247–248PubMedGoogle Scholar
  343. Ledigham JGG (1964) Ethacrynic acid parenterally in treatment and prevention of pulmonary edema. Lancet I:952–954Google Scholar
  344. Lee JB, Patak RV, Mookerjee BK (1976) Renal prostaglandins and the regulation of blood pressure and sodium and water homeostasis. Am J Med 60:798–816PubMedGoogle Scholar
  345. Leuschner F (1969) Chemie und Pharmakologie von 4-Chlor-5-sulfamyl-salicylsäure-2′,6′-dimethylanilid. In: Krück F, Leppla W (Hrsg) Klinische Pharmakologie der Diuretika. Urban & Schwarzenberg, München, S 193–203Google Scholar
  346. Leuschner F, Neumann W, Bahrmann H (1975) Pharmakologische und toxikologische Eigenschaften des Saluretikum Xipamid (4-Chlor-5-sulfamoyl-2′,6′-salicyloxylidid). Arzneimittelforsch 25:245–251PubMedGoogle Scholar
  347. Lewis PJ, Kohner EM, Petrie A, Dollery CT (1976) Deterioration of glucose tolerance in hypertensive patients on prolonged diuretic treatment. Lancet I:564–566Google Scholar
  348. Lichtwitz A, Parlier R, de Seze S, Hioco D, Miravet L (1961) L’effect hypocalciurique des sulfamides diuretiques. Sem Hop Paris 37:2350–2362Google Scholar
  349. Liddle GW (1957) Sodium diuresis induced by steroidal antagonists of aldosterone. Science 126:1016–1018PubMedGoogle Scholar
  350. Liddle GW (1958) Aldosterone antagonists. Arch Intern Med 102:998–1004Google Scholar
  351. Liddle GW (1960) Studies on aldosterone antagonism: experimentel eivdence and practical application. In: Bartter FC (ed) The clinical use of aldosterone antagonists. Thomas, Springfield, pp 14–23Google Scholar
  352. Liebenow W, Leuschner F (1975) Struktur-Wirkungsbeziehungen beim Diuretikum Xipamid (4-Chlor-5-sulfamoyl-2′,6′-salicyloxylidid). Arzneimittelforsch 25:240–244PubMedGoogle Scholar
  353. Lieberman FL, Bateman JR (1968) Megaloblastic anemia possibly induced by triamterene in patients with alcoholic cirrhosis. Ann Intern Med 68:168–173PubMedGoogle Scholar
  354. Lockhart EA, Dirks JH (1972) Effects of Triflocin on renal tubular reabsorption and blood flow distribution. Am J Physiol 223:89–96PubMedGoogle Scholar
  355. Lockwood RH, Lum BKB (1974) Effects of adrenergic agonists and antagonists on potassium metabolism. J Pharmacol Exp Ther 189:119–129PubMedGoogle Scholar
  356. Loew D, Meng K (1977) The renal mechanism of Bay g 2821. Pharmacotherapeutica 1:333–340Google Scholar
  357. Lopez-Ovejero JA, Weber MA, Drayer JIM, Sealey JE, Laragh JH (1978) Effects of indomethacin alone and during diuretic or β-adrenoceptor blockade therapy on blood pressure and the renin system in essential hypertension. Clin Sci Mol Med 55:203s–205s Google Scholar
  358. Losert W, Seuft G, Sitt R (1965) Hormonale Regulationsstörungen als Ursache der Benzothiadiazin-bedingten Kaliumverluste. Naunyn Schmiedebergs Arch Pharmacol 251:120–121Google Scholar
  359. Luboshitzky R, Tal-Or Z, Barilai D (1978) Chlorthalidone-induced syndrome of inappropriate secretion of antidiuretic hormone. J Clin Pharmacol 18:336–339PubMedGoogle Scholar
  360. Ludens JH, Hook JB, Brody MJ, Williamson HE (1968) Enhancement of renal blood flow by furosemide. J Pharmacol Exp Ther 163:456–460PubMedGoogle Scholar
  361. Ludens JH, Heitz DC, Brody MJ, Williamson HE (1970) Differential effects of furosemide on renal and limb blood flows in the conscious dog. J Pharmacol Exp Ther 171:300–306PubMedGoogle Scholar
  362. Lüderitz B, Naumann d’Alnoncourt C (1976) Einfluss diuretischer Substanzen auf elektrophysiologische Paramaeter des Herzens. Herz Kreisl 8:649–653Google Scholar
  363. Lüderitz B, Naumann d’Alnoncourt C, Avenhaus H, Boite HD (1972) Zur kardialen Wirkung der Aldosteronantagonisten — elektrophysiologische Messungen am Papillarmuskel des Herzens. Verh Dtsch Ges Inn Med 78:1066–1069PubMedGoogle Scholar
  364. Lüderitz B, Tiedemann W, Steinbeck G (1974) Elektrophysiologische Untersuchungen über die kardiale Wirkung von Amilorid. Verh Dtsch Ges Inn Med 80:1523–1527PubMedGoogle Scholar
  365. Lüderitz B, Naumann d’Alnoncourt C, Thomas E, Steinbeck G (1977a) Effects of diuretics on electrophysiological parameters of heart muscle cells. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Thieme, Stuttgart, pp 121–129Google Scholar
  366. Lüderitz B, Naumann d’Alnoncourt C, Steinbeck G (1977b) Direct effects of diuretic drugs on the myocardium. In: Riecker G, Weber A, Goodwin J (eds) Myocardial failure. Springer, Berlin Heidelberg New York, pp 297–310Google Scholar
  367. Maass AR, Wiebelhaus VD (1967) Die biologischen und diuretischen Eigenschaften von Triamterene. In: Fellinger K (Hrsg) Therapie mit Triamterene. Thieme, Stuttgart, S 2–21Google Scholar
  368. Maher JF, Schreiner GF (1965) Studies on ethacrynic acid in patients with refractory edema. Ann Intern Med 62:15–29PubMedGoogle Scholar
  369. Maher JF, O’Connell JMB, Setler JG, Schreiner GE (1964) Effect of ethacrynic acid in refractory edema. Clin Res 12:70 (Abstr)Google Scholar
  370. Malnic G, Steinmetz PR (1976) Transport processes in urinary acidification. Kidney Int 9:172–188PubMedGoogle Scholar
  371. Malnic G, Klose RM, Giebisch G (1964) Micropuncture study of renal potassium excretion in the rat. Am J Physiol 206:647–686Google Scholar
  372. Malnic G, Klose RM, Giebisch G (1966a) Micropuncture study of distal tubular potassium and sodium transport in rat nephron. Am J Physiol 211:529–547Google Scholar
  373. Malnic G, Klose RM, Giebisch G (1966b) Microperfusion study of distal tubular potassium and sodium transfer in rat kidney. Am J Physiol 211:548–559Google Scholar
  374. Malnic G, Mello Aires M, de Mello GM, Giebisch G (1972) Acidification of phosphate puffer in cortical tubules of rat kidney. Pfluegers Arch 331:275–278Google Scholar
  375. Mann NM (1963) Gynecomastia during therapy with spironolactone. JAMA 190:160–162Google Scholar
  376. Mann T, Keilin D (1940) Sulfanilamide as a specific inhibitor of carbonic anhydrase. Nature 146:164–165Google Scholar
  377. Manuel MA, Steele TH (1974a) Changes in renal urate handling after prolonged thiazide treatment. Am J Med 57:741–746Google Scholar
  378. Manuel MA, Steele TH (1974b) Pyrazinamide suppression of the uricosuric response to sodium chloride infusion. J Lab Clin Med 83:417–427Google Scholar
  379. Maren TH (1956) Carbonic anhydrase inhibition. The effect of metabolic acidosis on the response to Diamox. Bull Johns Hopk Hosp 98:159–183Google Scholar
  380. Maren TE, Mayer E, Wadsworth BC (1954) Carbonic anhydrase inhibition. I. The pharmacology of Diamox: 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide. Bull Johns Hopk Hosp 95:199–243Google Scholar
  381. Martinez-Maldonado M, Tsaparas N, Inagaki C, Schwartz A (1974) Interactions of digoxin and ethacrynic acid with renal sodium-potassium activated adenosine triphosphatase. J Pharmacol Exp Ther 188:605–614PubMedGoogle Scholar
  382. Mason J, Thurau K (1976) The physiological mechanism responsible for the adjustment of renal function during acute renal failure. Proc VI Internat Congr Nephrology. Karger, Basel, pp 572–577Google Scholar
  383. Matz GJ, Naunton RF (1968) Ototoxic drugs and poor renal function. JAMA 206:2119PubMedGoogle Scholar
  384. McGiff JC, Vane JR (1975) Prostaglandines and the regulation of blood pressure. Kidney Int [Suppl 5] 8:S262–S270Google Scholar
  385. Mehnert H, Stüdlein H, Förster H (1964) Klinische Beobachtungen zum blutzuckersteigernden Effekt saluretisch wirksmer Substanzen. Klin Wochenschr 42:1099–1100Google Scholar
  386. Meng K (1967) Mikropunktionsuntersuchungen über die saluretische Wirkung von Hydrochlorothiazid, Acetazolamid und Furosemid. Naunyn Schmiedebergs Arch Pharmakol 257:355–363Google Scholar
  387. Meng K (1969) Mikropunktionsuntersuchungen über die Wirkung von Diuretika in der Henle’schen Schleife. Klin Wochenschr 47:668–672PubMedGoogle Scholar
  388. Meng K, Kroneberg K (1965) Untersuchungen an der Ratte zur Frage der diabetogenen Wirkung von Saluretika. Naunyn Schmiedebergs Arch Pharmacol 251:433–444Google Scholar
  389. Meyer P, Menard J, Papanicolaou N, Alexandre N, Devaux JM, Milliez P (1968) Mechanism of renin release following furosemide diuresis in rabbit. Am J Physiol 215:908–915PubMedGoogle Scholar
  390. Mikolajewski V (1968) Beeinflussung der Folatreductase durch Triamteren und Triamterenderivate. Dissertation, Universität BerlinGoogle Scholar
  391. Miller WH, Dessert AM, Roblin RO (1950) Heterocyclic sulfonamides as carbonic anhydrase inhibitors. J Am Chem Soc 72:4893–4896Google Scholar
  392. Möller E, Horstmann H, Meng K (1977) The chemistry of muzolimine (Bay g 2821), a new nonsulphonamide diuretic. Pharmacotherapeutica 1:540–545Google Scholar
  393. Mokier CM (1960) Antiarrhythmic activity of various steroidal spirolactones in dogs. Proc Soc Exp Biol Med 105:257–259Google Scholar
  394. Mond H, Hunt D, Sloman G (1974) Haemodynamic effects of furosemide in patients suspected of having acute myocardial infarction. Br Heart J 36:44–53PubMedGoogle Scholar
  395. Monroe KE, Grant L, Sashara AA, Littmann D (1959) Effect of chlorothiazide on serum uric acid and uric acid excretion. N Engl J Med 261:290–292PubMedGoogle Scholar
  396. Moore PF (1968) The effects of diazoxide and benzothiazide diuretics upon phosphodiesterase. Ann NY Acad Sci 150:256–260PubMedGoogle Scholar
  397. Moret B (1965) Zur diabetogenen Wirkung der Saluretika. Dtsch Med Wochenschr 90:1136–1139PubMedGoogle Scholar
  398. Morgan T, Berliner RW (1969) A study by continuous microperfusion of water and electrolyte movement in the loop of Henle and distal tubule of the rat. Nephron 6:388–405PubMedGoogle Scholar
  399. Morgan T, Tadokoro M, Martin D, Berliner RW (1970) Effect of furosemide on Na and K transport studies by microperfusion of the rat nephron. Am J Physiol 218:292–297PubMedGoogle Scholar
  400. Muschaweck R, Hajdu P (1964) Die salidiuretische Wirksamkeit der Chlor-N-(2-furylmethyl)-5-sulfamyl-anthranilsäure. Arzneimittelforsch 14:44–47PubMedGoogle Scholar
  401. Musgrave GE, Born CK, Davidson CP, Hamrick ME (1977) Interaction of spironolactone and digoxin in dogs. J Pharmacol Exp Ther 202:696–701PubMedGoogle Scholar
  402. Nager F (1976) Digitalis- und Diuretikatherapie der Herzinsuffizienz. Schweiz Rundschau Med (Praxis) 65:911–922Google Scholar
  403. Nash HL, Fitz AE, Wilson WR, Kirkendall WM, Kioschos JM (1966) Cardiorenal hemodynamic effects of ethacrynic acid. Am Heart J 71:153–165PubMedGoogle Scholar
  404. Naumann d’Alnoncourt C, Hornberger M, Lüderitz B (1976) Interaktionen von Triamteren und Herzglykosiden am Erregungsleitungssystem des Herzens. Verh Dtsch Ges Inn Med 82:1236–1239PubMedGoogle Scholar
  405. Navar LG (1978) Renal autoregulation : perspectives from whole kidney and single nephron studies. Am J Physiol 234:F357–F370Google Scholar
  406. Nechtwatel W, Stange A, Sigel H, Kress P, Resch A, Stauch M (1982) Der Einfluss von Piretanid auf die zentrale Haemodynamik und Belastungstoleranz von Patienten mit Angina pectoris. Herz/Kreisl 14:91–96Google Scholar
  407. Nies AS (1975) Adverse reactions and interactions limiting the use of antihypertensive drugs. Am J Med 58:495–503PubMedGoogle Scholar
  408. Noble MIM, Trenchard D, Guz A (1966) The value of diuretics in respiratory failure. Lancet II:257–262Google Scholar
  409. Noel PR, Leahy (1962) The estimation of the activity of aldosterone antagonist in man: Spironolactone (Aldactone) activity. Clin Sci 23:477–483Google Scholar
  410. Novak LP, Harrison CE Jr (1973) Abnormalities of cellular potassium concentration in uncompensated and compensated congestive heart failure. Mayo Clin Proc 48:107–113PubMedGoogle Scholar
  411. Novello FC, Sprague JM (1957) Benzothiadiazine dioxides as novel diuretics. J Am Chem Soc 79:2028–2029Google Scholar
  412. Ochs H, Bodem G (1976) Pharmakokinetische und pharmakodynamische Grundlagen einer Behandlung mit Spironolactonen. Inn Med 3:469–477Google Scholar
  413. Ogilvie RI, Ruedy J (1971) Hemodynamic effect of ethacrynic acid in anephric dogs. J Pharmacol Exp Ther 176:389–396PubMedGoogle Scholar
  414. Ogilvie RI, Schlieper E (1971) Comparative effects of ethacrynic acid, furosemide, and diazoxide in the perfused dog hindlimb. Can J Physiol Pharmacol 49:1038–1043PubMedGoogle Scholar
  415. Olesen KH, Sigurd B, Steiness E, Leth A (1973) Bumetanide, a new potent diuretic. A clinical evaluation in congestive heart failure. Acta Med Scand 193:119–131PubMedGoogle Scholar
  416. Olsen UB (1977) The pharmacology of bumetanide : A review. Acta Pharmacol Toxicol [Suppl 3] (Kbh) 41:1–29Google Scholar
  417. Oren BG, Rich M, Belle MS (1958) Chlorothiazide (Diuril) as a hyperuricemic agent. JAMA 168:2128–2129Google Scholar
  418. Orloff J, Wagner HN Jr, Davidson DG (1958) The effect of variations in solute excretion and vasopressin dosage in the excretion of water in the dog. J Clin Invest 37:458–464PubMedGoogle Scholar
  419. Østergaard EH, Magnussen MP, Nielsen CK, Eilertsen E, Frey HH (1972) Pharmacological properties of 3-n-butylamino-4-phenoxy-5-sulfamylbenzol acid (Bumetanide), a new potent diuretic. Azneimittelforsch 22:66–72Google Scholar
  420. Paintal AS (1973) Vagal sensory receptors and their reflex effects. Physiol Rev 53:159–227PubMedGoogle Scholar
  421. Parfitt AM (1969) Chlorothiazide-induced hypercalcemia in juvenile osteoporosis and hyperparathyroidism. N Engl J Med 281:55–59PubMedGoogle Scholar
  422. Parfitt AM (1972) The interactions of thiazide diuretics with parathyroid hormone and vitamin D: Studies in patients with hypoparathyroidism. J Clin Invest 51:1879–1888PubMedGoogle Scholar
  423. Patak RV, Mookerjee BK, Bentzel CJ, Hysert PE, Baben M, Lee JB (1975) Antagonism of the effects of furosemide by indomethacin in normal and hypertensive man. Prostaglandins 10:649–659PubMedGoogle Scholar
  424. Perry HM (1977) Treatment of mild hypertension. Veterans Administration NHLBI study group for cooperative studies on antihypertensive therapy: mild hypertension. Circ Res [Suppl I] 40:1180–1189Google Scholar
  425. Peters G, Guidoux R, Grassi L (1966) Die diabetogene Wirkung von N-Monomethylacetamid. Naunyn Schmiedebergs Arch Pharmacol 255:58–59Google Scholar
  426. Pickleman JR, Straus II FH, Forland M, Paloyan E (1969) Thiazide-induced parathyroid stimulation. Metabolism 18:867–873PubMedGoogle Scholar
  427. Pillay VKG, Schwartz FD, Aimi K, Kark RM (1969) Transient and permanent deafness, following treatment with ethacrynic acid in renal failure. Lancet I:77–79Google Scholar
  428. Pinson R Jr, Schreiber EC, Wiseman EH, Chiaini J, Baumgartner D (1962) The fate and excretion of polythiazide in the dog. J Med Pharm Chem 5:491–503Google Scholar
  429. Pitts RF, Alexander RS (1945) The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144:239–254Google Scholar
  430. Pitts RF, Krück F, Lozano R, Taylor DW, Heidenreich OPA, Kessler RH (1958) The mechanism of diuretic action of chlorothiazide. J Pharm Exp Therap 123:89–97Google Scholar
  431. Poole-Wilson PA, Cobbe SM, Fry CH (1978) Acute effects of diuretics on potassium exchange, mechanical function and the action potential in rabbit myocardium. Clin Sci Mol Med 55:555–559Google Scholar
  432. Popovtzer MM, Subryan AC, Alfrey AC, Reeve EB, Schrier RW (1975) The acute effect of chlorothiazide on serum-ionized calcium. Evidence for a parathyroid hormonedependent mechanism. J Clin Invest 55:1295–1302PubMedGoogle Scholar
  433. Porter RH, Cox BG, Heaney D, Hostetter TH, Stinebrugh BJ, Suki WN (1978) Treatment of hypoparathyroid patients with chlorthalidone. N Engl J Med 298:577–581PubMedGoogle Scholar
  434. Prazma J, Pecorak JB (1975) Ethacrynic acid. Effects on the cochlear potentials in normal and high blood oxygen. J Clin Invest 55:840–844PubMedGoogle Scholar
  435. Prazma J, Thomas WG, Fischer ND, Presler MJ (1972) Ototoxicity of ethacrynic acid. Arch Otolaryngol 95:448–456PubMedGoogle Scholar
  436. Pugh LCG, Wyndham (1949) The circulatory effects of mercurial diuretics in congestive heart failure. Clin Sci 8:11–19PubMedGoogle Scholar
  437. Pulver R, Wirz H, Stenger EG (1959) Über das Verhalten des Diureticums Hygroton (G 93 182) im Stoffwechsel. Schweiz Med Wochenschr 89:1130–1133PubMedGoogle Scholar
  438. Quick CA, Duvall AJ (1970) Early changes in the cochlear duct from ethacrynic acid: An electronmicroscopic evaluation. Laryngoscope 80:954–965PubMedGoogle Scholar
  439. Rader B, Smith WW, Barger AR, Eichna LW (1964) Comparison of the hemodynamic effects of mercurial diuretics and digitalis in congestive heart failure. Circulation 29:328–344PubMedGoogle Scholar
  440. Radtke HW, Rumrich G, Kinne-Saffran E, Ullrich KJ (1970) Dual action of acetazolamide and furosemide on proximal volume absorption in the rat kidney. Kidney Int 1:100–105Google Scholar
  441. Ramirez A, Abelman WH (1968) Hemodynamic effects of diuretics by ethacrynic acid in normal subjects and in patients with congestive heart failure. Arch Intern Med 121:320–327PubMedGoogle Scholar
  442. Rapoport ML, Hurd HF (1964) Thiazide-induced glucose intolerance treated with potassium. Arch Intern Med 113:405–408PubMedGoogle Scholar
  443. Rector FC, Brunner FP, Sellman JC, Seldin DW (1966) Pittfalls in the use of micropuncture for the localization of diuretic action. Ann NY Acad Sci 139:400–407PubMedGoogle Scholar
  444. Reutter F, Labhart A (1961) Saluretika und Glucosetoleranz. Helv Med Acta 28:487–495PubMedGoogle Scholar
  445. Reutter F, Schaub F (1959) Klinische Untersuchungen und Erfahrungen mit Hygroton, einem neuartigen, oral wirksamen Diureticum. Schweiz Med Wochenschr 89:1158–1165Google Scholar
  446. Richet G, Hagege J, Gabe M (1970) Corrélations entre les transferts de bicarbonate et la morphologie du segment terminal du nephron chez le rat. Nephron 7:413–429PubMedGoogle Scholar
  447. Richterich R (1958) Erfahrungen mit Chlotride, einem neuen qucksilberfreien Diuretikum in der Therapie cardialer Ödeme. Schweiz Med Wochenschr 88:906–910PubMedGoogle Scholar
  448. Richterich R (1959) Experimentell-klinische Untersuchungen über Hydrochlorothiazid, (Esidrex), ein neues diuretisch wirksames Sulfonamid. Klin Wochenschr 37:355–365PubMedGoogle Scholar
  449. Roblin RO, Clapp JW (1950) The preparation of heterocyclic sulfonamides. Am Chem Sox 72:4890–4892Google Scholar
  450. Rocha AS, Kokko JP (1973) Sodium chloride and water transport in the medullary thick ascending limb of Henle: Evidence for active chloride transport. J Clin Invest 52:612–623PubMedGoogle Scholar
  451. Roos JC, Boer P, Koomans HA et al. (1981) Hemodynamic and hormonal changes during acute and chronic diuretic treatment in essential hypertension. Eur J Clin Pharmacol 19:107–112PubMedGoogle Scholar
  452. Rose LI, Underwood RH, Newmark SR, Kisch ES, Williams GH (1977) Pathophysiology of spironolactone-induced gynecomastia. Ann Intern Med 87:398–403PubMedGoogle Scholar
  453. Rosenberg B, Dobkin GB, Wolentz A (1964) Intravenous use of ethacrynic acid in management of acute pulmonary edema. Circulation [Suppl 4] 30:147Google Scholar
  454. Rosenberg L, Shapiro S, Slone D, Kaufman DW, Miettinen OS, Stolly PD (1980) Thiazides and acute cholecystitis. N Engl J Med 303:546–548PubMedGoogle Scholar
  455. Rosenthal J, Boucher R, Nowaszynski W, Genest J (1968) Acute changes in plasma volume, reninactivity, and free aldosterone levels in healthy subjects following frusemide administration Canad J Physiol Pharmaco 46:85–91Google Scholar
  456. Rossier PH, Reutter F, Frick P (1961) Das hyperosmolale nichtazidotische Koma bei Diabetes mellitus. Dtsch Med Wochenschr 86:2145–2148PubMedGoogle Scholar
  457. Rowe GG, Afonso S, Castillo CA, Lowe WC, Crumpton CW (1962) Systemic and coronary hemodynamic effects of Triamterene (2,4,7-Triamino-6-Phenyl Pteridine). Proc Soc Exp Biol Med 110:27–29PubMedGoogle Scholar
  458. Rutledge R, Barrett WE, Plummer AJ (1961) The comparative diuretic acitivty of some analogues of cyclopenthaizide (Navidex). Fed Proc 20:409Google Scholar
  459. Sagild U, Anderson V, Andreasen PG (1961) Glucose tolerance and insulin responsiveness in experimental potassium depletion. Acta Med Scand 169:243–251PubMedGoogle Scholar
  460. Samaan N, Dollery CT, Fraser R (1963) Diabetogenic action of benzothiadiazines. Lancet 1:1244–1246Google Scholar
  461. Samet P, Bernstein WH (1968) Acute effects of intravenous ethacrynic acid upon cardiovascular dynamics. Am J Med Sci 255:78–83Google Scholar
  462. Sato K (1973) Inhibition of respiration in the isolated eccrine sweet gland by ethacrynic acid. Pfluegers 341:233–242Google Scholar
  463. Satzinger G (1977) Struktur-Aktivitäts-Betrachtungen zu Etozolin, einem neuartigen Diuretikum. Arzneimittelforsch 27:1742–1745PubMedGoogle Scholar
  464. Saxl P, Heilig R (1920) Über die diuretische Wirkung von Novasurol und anderen Quecksilberinjektionen. Wien Klin Wochenschr 33:943–944Google Scholar
  465. Schad H, Seller H (1976) Reduction of renal nerve activity by volume expansion in conscious cats. Pfluegers Arch 363:155–159Google Scholar
  466. Schafter JA, Patlak CS, Andreoli TE (1975) A component of fluid absorption linked to passive ion flows in the superficial pars recta. J Gen Physiol 66:445–471Google Scholar
  467. Schaumann W (1962) Zum Wirkungsmechanismus von 2-,4-,7-Triamino-6-phenylpteridin (Triamteren). Klin Wochenschr 40:756PubMedGoogle Scholar
  468. Schedl HP, Bartter FC (1960) An explanation for and experimental correction of the abnormal water diuresis in cirrhosis. J Clin Invest 29:248–261Google Scholar
  469. Scheinman M, Brown M, Rapaport E (1971) Hemodynamic effects of ethacrynic acid in patients with refractory acute left ventricular heart failure. Am J Med 50:291–296PubMedGoogle Scholar
  470. Schirmeister J, Willmann H (1964) Über die Harnsäure- und andere Clearances nach intravenöser Gabe von Furosemide beim Menschen. Klin Wochenschr 43:523–628Google Scholar
  471. Schirmeister J, Man NK, Hailauer W, Keller P (1969) Lactat und Harnsäurestoffwechsel unter Einwirkung von Saluretika. Verh Dtsch Ges Inn Med 75:120–123PubMedGoogle Scholar
  472. Schlebusch H, Sorger M, Höck A, Krück F (1981) Kaliumbestimmungen in Leukozyten. In: Krück F, Schrey A (Hrsg) Diuretika II. Wolf, München, S 106–116Google Scholar
  473. Schmid E, Fricke G (1969) Studies on urinary excretion of the potassium-retaining diuretic Amiloride (Desmethyl-pipazuroyl-guanidine, MK 870) in man. Pharmacologia Clinica 1:110–113Google Scholar
  474. Schmidt U, Dubach UC (1975) Regulation of Na +-K +-ATPase in the nephron: Inhibition of aldosterone induced activation by spironolactone. Proc Internat Congr Nephrology, R 32Google Scholar
  475. Schnaper H, Fitz A, Frohlich E, Goldman A, Perry HM Jr, Steele B (1977) Chlorthalidone and serum cholesterol. Lancet II:295Google Scholar
  476. Schneider WJ, Becker EL (1966) Acute transient hearing loss after ethacrynic acid therapy. Arch Intern Med 117:715–717PubMedGoogle Scholar
  477. Schnermann J (1975) Regulation of single nephron filtration rate by feedback: Facts and theories. Clin Nephrol 3:75–81PubMedGoogle Scholar
  478. Schnermann J, Briggs JP (1981) Participation of renal cortical prostaglandins in the regulation of glomerular filtration rate. Kidney Int 19:802–815PubMedGoogle Scholar
  479. Schnermann J, Wright FS, Davis JM, Stackelberg W v, Gill G (1970) Regulation of superficial nephron filtration rate by tubulo-glomerular feedback. Pfluegers Arch 318:147–175Google Scholar
  480. Schnermann J, Hermle M, Schmidmeier E, Dahlheim H (1975) Impaired potency for feedback regulation of glomerular filtration rate in DOCA expanded rats. Pfluegers Arch 358:325–338Google Scholar
  481. Schnermann J, Ploth DW, Hermle M (1976) Activation of tubuloglomerular feedback by chloride transport. Pfluegers Arch 362:229–240Google Scholar
  482. Schoenfield MR, Goldberger E (1964) Hypercholesterinemia indiced by thiazides: A pilot study. Curr Ther Res 6:180–184Google Scholar
  483. Schrier RW, Lehman D, Zacherle B, Earley LE (1973) Effect of furosemide on free water excretion in edematous patients with hyponatremia. Kidney Int 3:30–34PubMedGoogle Scholar
  484. Schrier RW, Miller PD, Lacher JW (1977) Diuretics and hyponatrenia. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Thieme, Stuttgart, pp 184–192Google Scholar
  485. Schröder R, Schüren KP, Biamino G, Dennert J, Meyer V, Sadee W (1971a) Die Wirkung von Aldactone auf Herzdynamik und Kontraktilität. Verh Dtsch Ges Kreislaufforsch 37:438Google Scholar
  486. Schröder R, Ramdohr B, Hüttemann U, Leitner E, Schüren KP (1971b) Direkte positiv inotrope Herzwirkung durch orale Spironolacton-Behandlung. Verh Dtsch Ges Kreislaufforsch 38:349–353Google Scholar
  487. Schröder R, Schüren KP, Biamino G, Meyer V, Sedee W (1971c) Positiv inotrope Herzwirkung von Aldadiene-Kalium (Aldactone pro injectione). Klin Wochenschr 49:1093Google Scholar
  488. Schröder R, Ramdohr B, Hüttemann U, Schüren KP (1972) Direkte positiv-inotrope Herzwirkung von Aldactone (Spironolacton, Canrenoat-Kalium). Dtsch Med Wochenschr 97:1535–1538PubMedGoogle Scholar
  489. Schultz EM, Cragoe EJ Jr, Bicking JB, Bolhofer WA, Sprague JM (1962) α,β-unsatured Ketone derivatives of aryloxyacetic acids, a new class of diuretics. J Med Pharm Chem 5:660–662Google Scholar
  490. Schultz G, Losert W, Senft G, Sitt R (1966) Vergleichende Untersuchungen über den Einfluss von Diazoxide, Hydrochlorothiazide und Furosemid auf den Kohlenhydratstoffwechsel der Ratte. Naunyn Schmiederbergs Arch 255:74–76Google Scholar
  491. Schwarting G (1959) Diuretische und saluretische Wirkungen von Chlorothiazid unter normalen und pathologischen Bedingungen. Klin Wochenschr 37:476–483PubMedGoogle Scholar
  492. Schwartz GH, David DS, Riggio RR, Stenzel KH, Rubin AL (1970) Ototoxicity induced by furosemide. N Engl J Med 282:1413–1414PubMedGoogle Scholar
  493. Schwartz WB (1949) Effect of sulfanilamide on salt and water excretion in congestive heart failure. N Engl J Med 240:173–177PubMedGoogle Scholar
  494. Schwartz WB, van Ypersele de Strihou C, Kassirer JP (1968) Role of anions in metabolic alcalosis and potassium deficiency. N Engl J Med 279:630–639PubMedGoogle Scholar
  495. Seely JF, Dirks JH (1977) Site of action of diuretics drugs. Kidney Int 11:1–8PubMedGoogle Scholar
  496. Seitz H, Jaworski FF (1964) Effect of hydrochlorothiazide on serum and urinary calcium and urinary citrate. Can Med Assoc J 90:414–420PubMedGoogle Scholar
  497. Seldin DW, Eknoyan G, Suki WN, Rector FC Jr (1966) Localization of diuretic action from the pattern of water and electrolyte excretion. Ann NY Acad Sci 139:328–343PubMedGoogle Scholar
  498. Seller RH, Banach S, Nameh T, Neff M, Swartz G (1975a) Cardiac effect of diuretic drugs. Am Heart J 89:493–500Google Scholar
  499. Seller RH, Greco J, Banach S, Seth R (1975b) Increasing the inotropic effect and toxic dose of digitalis by the administration of antikaliuretic drugs — further evidence for a cardiac effect of diuretic agents. Am Heart J 90:56–67Google Scholar
  500. Seltzer HS, Allen EW (1969) Hyperglycemia and inhibition of insulin secretion during administration of diazoxide and trichlormethiazide. Diabetes 18:19–28PubMedGoogle Scholar
  501. Selye H (1969) Effect of various diuretics upon experimental cardiac necrosis. Am Heart J 77:653–656PubMedGoogle Scholar
  502. Settle HP Jr, Munsie WJ, Owen JA Jr (1968) Toxic effects of a chlorothiazide-diazoxide combination on adipose tissue and kidneys of intact rats. Diabetologia 4:136–140PubMedGoogle Scholar
  503. Shanklin DR (1962) Pancreatic atrophy apparently secondary to hydrochlorothiazide. N Engl J Med 266:1097–1099PubMedGoogle Scholar
  504. Shapiro AP, Benedek TG, Small JL (1961) Effect of thiazides on carbohydrate metabolism in patients with hypertension. N Engl J Med 265:1028–1033Google Scholar
  505. Sharp GWG, Komack CL, Leaf A (1966) Studies on the binding of aldosterone in the toad bladder. J Clin Invest 45:450–459PubMedGoogle Scholar
  506. Shepherd JT (1973) Intrathoracic Baroreflexes. Mayo Clin Proc 48:426–437PubMedGoogle Scholar
  507. Shepherd JT (1981) The lungs as Receptor sites for cardiovascular regulation. Circulation 63:1–10PubMedGoogle Scholar
  508. Sjorgen A (1970) The earley haemodynamic effects of ouabain and furosemide in patients with acute myocardial infarction and raised pulmonary artery diatolic pressure. Acta Med Scand [Suppl] 510:53–55Google Scholar
  509. Skorecki KL, Brenner BM (1981) Body fluid homeostasis in man. A contemporary overview. Am J Med 70:77–88PubMedGoogle Scholar
  510. Slone D, Iick H, Lewis GP, Shapiro S, Miettinen OS (1969) Intravenously given ethacrynic acid and gastrointestinal bleeding. JAMA 209:1668–1671PubMedGoogle Scholar
  511. Sotornik I, Schück O, Stribrná J (1969) Influence of diuretics on renal calcium excretion. Experientia (Basel) 25:591–592Google Scholar
  512. Southworth H (1937) Acidosis associated with the administration of paraamino-benezenesulfonamide (Prontylin). Proc Soc Exp Biol Med 36:58–61Google Scholar
  513. Spear GS (1964) The glomerulus in cyanotic congenital heart diseae and primary pulmonary hypertension. A review. Nephron 1:238–248Google Scholar
  514. Sprague JM (1958) The chemistry of diuretics. Ann NY Acad Sci 71:328–343PubMedGoogle Scholar
  515. Squires RD, Crosley AP Jr, Elkinton JR (1951) The distribution of body fluids in congestive heart failure: III. Exchanges in patients during diuresis. Circulation 4:868–880PubMedGoogle Scholar
  516. Stampfer M, Epstein SE, Beiser GD, Braunwald E (1968) Hemodynamic effects of Diuresis at rest and during intense upright exercise in patients with impaired cardiac function. Circulation 37:900–911PubMedGoogle Scholar
  517. Starling EH (1896) On the absorption of fluid from the connective tissue spaces. J Physiol (Lond) 19:312–316Google Scholar
  518. Statson WB, Cannon PJ, Heinemann HO, Laragh JH (1966) Furosemide: A clinical evaluation of its diuretic action. Circulation 34:910–920Google Scholar
  519. Steele TH (1969) Evidence for altered renal urate reabsorption during changes in volume of the extracellular fluid. J Lab Clin Med 74:288–299PubMedGoogle Scholar
  520. Steele TH, Oppenheimer S (1969) Factors affecting urate excretion following diuretic administration in man. Am J Med 47:564–574PubMedGoogle Scholar
  521. Stein JH, Wilson CB, Kirkendall WM (1968) Differences in the acute effects of furosemide and ethacrynic acid in man. J Lab Clin Med 71:654–665PubMedGoogle Scholar
  522. Steiness E (1974) Renal tubular secretin of digoxin. Circulation 50:103–107PubMedGoogle Scholar
  523. Steinmüller SR, Puschett JB (1972) Effects of metolazone in man: comparison with chlorothiazide. Kidney Int 1:169–181PubMedGoogle Scholar
  524. Stenger EG (1959) Die diuretische Wirkung neuer Sulfamylderivate. Bull Schweiz Akad Med Wiss 15:339–345PubMedGoogle Scholar
  525. Stenger EG, Witz H, Pulver R (1959) Hygroton (G 33182), ein neues Salidiureticum mit protrahierter Wirkung. Schweiz Med Wochenschr 89:1126–1130PubMedGoogle Scholar
  526. Stevens G de, Werner LH, Halamandaris A, Ricca S Jr (1958) Dihydrobenzothiadiazine dioxides with potent diuretic effect. Experientia (Basel) 14:463Google Scholar
  527. Stock E (1970) Furosemide after recent myocardial infarction. Med J Aust 1:480–481PubMedGoogle Scholar
  528. Stoner LC (1979) Studies with Amiloride on isolated distal nephron segments. In: Cuthberg AW, Farelli GM, Scriabine A (eds) Amiloride and epithelial sodium transport. Urban & Schwarzenberg, Baltimore, pp 51–60Google Scholar
  529. Stoner LC, Burg MB, Orloff J (1974) Ion transport in cortical collecting tubule effect of amiloride. Am J Physiol 227:453–459PubMedGoogle Scholar
  530. Stote RM, Schmith LH, Wilson DM, Dube WJ, Goldsmith RS, Arnauld CD (1972) Hydrochlorothiazide effects on serum calcium and immunoreactive parathyroid hormone concentrations. Studies in normal subjects. Ann Intern Med 77:587–591PubMedGoogle Scholar
  531. Strandhoy JF, Williamson HE (1971) The effect of furosemide and hydrochlorothiazide on renal blood flow and sodium excretion in dogs with reduced renal blood flow. Pharmacologist 13:226Google Scholar
  532. Strauer BE (1972a) Evidence for a positive inotropic effect of aldadiene (−K, −Na) on the isolated ventricular myocardium. Klin Wochenschr 50:387–389Google Scholar
  533. Strauer BE (1972b) Contractile responses to morphine, piritramide, meperidine, and fentanyl: A comparative study of effects on the isolatd ventricular myocardium. Anesthesiology 37:304–310Google Scholar
  534. Strauer BE (1973a) Force-velocity relations of isotonic relaxation in mammalian heart muscle. Am J Physiol 224:431–434Google Scholar
  535. Strauer BE (1973b) The influence of the aldosterone-antagonist Spironolactone on myocardail contractility. Arch Int Pharmacodyn Ther 201:59–70Google Scholar
  536. Strauer BE, Avenhaus H, Nose M (1972) Die Wirkung von Aldadiene (−K, −Na) auf Herzmechanik und Contraktilität des isolierten Ventrikelmyocard. Klin Wochenschr 50:387–389PubMedGoogle Scholar
  537. Strauss H (1903) Zur Behandlung und Verhütung der Nierenwassersucht. Ther Ggw 5:193–195Google Scholar
  538. Strauss MB, Southworth H (1938) Urinary changes due to sulfamilamide administration. Bull Johns Hopk Hosp 63:41–45Google Scholar
  539. Strieder N, Khuri RN, Wiederholt M, Giebisch G (1974) Studies on renal action of ouabein in the rat. Effects in the nondiuretic state. Pfluegers Arch 349:91–107Google Scholar
  540. Suki W, Rector FJ Jr, Seidin DW (1965) The site of action of furosemide and other sulfonamide diuretics in the dog. J Clin Invest 44:1458–1469PubMedGoogle Scholar
  541. Suki WN, Hull AR, Rector FC, Seldin DW (1967) Mechanism of the effect of thiazide diuretics on calcium and uric acid (Abstr). J Clin Invest 46:1121Google Scholar
  542. Suki WN, Yium JJ, von Minden M, Saller-Herbert C, Eknoyan G, Martinez-Monaldo M (1970) Acute treatment of hypercalcemia with furosemide. N Engl J Med 283:836–840PubMedGoogle Scholar
  543. Suki WN, Rouse D, Ng RCK, Kokko JP (1980) Calcium transport in the tick ascending limb of Henle. Heterogeneity of function in the medullary and cortical segments. J Clin Invest 66:1004–1009PubMedGoogle Scholar
  544. Sullivan LP, Pirch JH (1966) Effect of bendroflumethiazide on distal nephron transport of sodium, potassium and chloride. J Pharmacol Exp Ther 151:168–179PubMedGoogle Scholar
  545. Swan HJC (1977) Hemodynamic effects of furosemide in heart failure in man. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Tieme, Stuttgart, pp 151–162Google Scholar
  546. Szatalowicz VL, Miller PD, Lacher JW, Gordon JA, Schrier RW (1982) Comparative effects of diuretics in hyponatraemic oedematous disorders. Clin Sci 62:235–238PubMedGoogle Scholar
  547. Tambyah JA (1969) Effect of frusemide on calcium excretion. Br Med J I:751–752Google Scholar
  548. Tanz RD (1959) Relative inotropic actions of some steroids upon isolated cardiac tissue. Circulation 20:777 (Abstr)Google Scholar
  549. Tanz RD (1962) Studies on the inotropic action of aldosterone on isolated cardiac tissue proparation including the effects of pH, ouabain and SC-8109. J Pharmacol Exp Ther 135:71–78PubMedGoogle Scholar
  550. Tarazi RC, Dustan HP, Fröhlich ED (1970) Long-term thiazide therapy in essential hypertension. Circulation 41:709–717PubMedGoogle Scholar
  551. Tasker PRW, Mitchell-Heggs PF (1976) Non-ketotic diabetic precoma associated with high-dose frusemide therapy. Br Med J 1:626–627PubMedGoogle Scholar
  552. Tattersfield AE, Mc Nicol NW (1970) Diuretics in acute myocardial infarction. Clin Sci 28:32PGoogle Scholar
  553. Thurau K (1964) Renal hemodynamics. Am J Med 36:698–719PubMedGoogle Scholar
  554. Thurau K (1966) Nature of autoregulation of renal blood flow. Proc 3rd Int Nat Contr Nephrology 1:162–173Google Scholar
  555. Thurau K (1974) JGA renin activity. Constituent of single nephron function and dependance on NaCl at the macula densa. Proc Vth Internat Congr Nephrology 2:183–192Google Scholar
  556. Thurau K (1977) Diuretics and tubuloglomerular feedback regulation of GFR. In: Siegenthaler W, Beckerhoff R, Vetter W (ed) Diuretics in research and clinics. Thieme, Stuttgart, pp 43–50Google Scholar
  557. Thurau K, Mason J (1974) The intrarenal function of the juxtaglomerular apparatus. In : Guyton AC, Thurau K (eds) MTP international review of science. Kidney and urinary tract physiology; Physiology Ser 1, vol IV. University Park Press, Baltimore, pp 357–389Google Scholar
  558. Thurau K, Mylle M (1965) Mikropunktionsversuche zur Funktion des juxtaglomerulären Apparates der Warmblüterniere. In: Ullrich KJ, Hierholzer K (Hrsg) Normale und pathologische Funktionen des Nierentubulus. Huber, Bern Stuttgart, S 113–118Google Scholar
  559. Thurau K, Schnermann J (1965) Die Natriumkonzentration an den Macula densa-Zellen als regulierender Faktor für das Glomerulumfiltrat. Klin Wochenschr 43:410–413PubMedGoogle Scholar
  560. Thurau K, Wober E (1962) Zur Lokalisation der autoregulativen Widerstandsänderungen in der Niere. Pfluegers Arch 274:553–566Google Scholar
  561. Thurau K, Dahlheim H, Grüner A, Mason J, Granger P (1972) Activation of renin in the single juxtaglomerular apparatus by sodium chloride in the tubular fluid at the macula densa. Circ Res 30/31:II182–II186Google Scholar
  562. Thurau K, Vogt C, Dahlheim H (1976) Renin activity in the juxtaglomerular apparatus of the rat during post-ischemic acute renal failure. Kidney Int 10:S177–S182Google Scholar
  563. Tiggeler RGWL, Koene RAP, Wijdevela PGAB (1977) Inhibition of frusemide-induced natriuresis by indomethacin in patients with nephrotic syndrome. Clin Sci Mol Med 52:149–151PubMedGoogle Scholar
  564. Tisch DE, Hoekstra JB, Pindell MH (1959) Pharmacology of two new oral diuretic agents: 7-sulfamyl-6-trifluoromethyl-1,2,4-benzothiadiazine-1,1-dioxide (Bl-H 320) and 7-sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide(BLH 346). Fed Proc 18:451Google Scholar
  565. Toivonen S, Mustala O (1966) Diabetogenic action of frusemide. Br Med J I:920–921Google Scholar
  566. Torrente A de, Robertson GL, Mc Donald KM, Schrier RW (1975) Mechanism of diuretic response to increased left atrial pressure in the anesthetized dog. Kidney Int 8:355–361PubMedGoogle Scholar
  567. Tschöpe W, Schmidt-Gayk H, Ritz E, Christ D, Beck C (1978) Thiazid (TH)-Therapie bei idiopatischer Hypercalciurie (IHC). Einfluss auf Parathormon (PTH)-Sekretion. Verh Dtsch Ges Inn Med 84:820–824PubMedGoogle Scholar
  568. Turino GM, Goldring RM, Heinemann HO (1974) Renal response to mechanical ventilation in patients with chronic hypercapnia. Am J Med 56:151–161PubMedGoogle Scholar
  569. Tweeddale MG, Ogilvie RI (1973) Antagonism of spironolactone-induced natriuresis by aspirin in man. N Engl J Med 289:198–200PubMedGoogle Scholar
  570. Vander AJ (1967) Control of renin release. Physiol Rev 47:359–382PubMedGoogle Scholar
  571. Vander AJ, Carlson J (1969) Mechanism of the effect of furosemide on renin secretion in anesthetized dogs. Circ Res 25:145–152PubMedGoogle Scholar
  572. Vander AJ, Luciano JR (1967) Effects of mercurial diuresis and acute salt deplation on renin release in dog. Am J Physiol 212:651–656PubMedGoogle Scholar
  573. Vander AJ, Miller R (1964) Control of the renin secretion of the dog. Am J Physiol 207:537–545PubMedGoogle Scholar
  574. Vander AJ, Malvin RL, Wilde WS, Sullivan LP (1958) Reexamination of salt and water retention in congestive heart failure: Significance of renal filtration fraction. Am J Med 25:497–502PubMedGoogle Scholar
  575. Vander AJ, Wilde WS, Malvin RL (1960) Stop flow analysis of aldosterone and steroidal antagonist SC 8109 on renal tubular sodium transport kinetics. Proc Soc Exp Biol Med 103:525–527PubMedGoogle Scholar
  576. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirinlike drugs. Nature New Biol 231:232–235PubMedGoogle Scholar
  577. Vollmer KO, Hodenberg A v, Poisson A, Gladigau V, Hengy H (1977) Resorption, Verteilung, Metabolismus und Ausscheidung von 14 C-Etozolin bei Ratte, Hund und Mensch. Arzneimittelforsch 27:1767–1776PubMedGoogle Scholar
  578. Vorburger C (1966) Propriétés et mode d’action de la furosemide. J Urol Nephrol (Paris) 72:581–590Google Scholar
  579. Waldorff S, Buch J (1979) Canrenoate — a spironolactone metabolic. Acute cardiac effects in digitalized patients. Eur J Cardiol 10:143–149PubMedGoogle Scholar
  580. Waldorff S, Andersen JD, Hieboll-Nielsen N, Nielsen OG, Moltke E, Sørensen U, Steiness E (1978) Spironolactone-induced changes in digoxin kinetics. Clin Pharmacol Ther 24:162–167PubMedGoogle Scholar
  581. Waldorff S, Berning J, Buch J, Steiness E (1982) Systolic time Intervalls during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease. Eur J Clin Pharmacol 21:269–273PubMedGoogle Scholar
  582. Walker WG (1966) Indications and contraindications for diuretic therapy. Ann NY Acad Sci 139:481–496PubMedGoogle Scholar
  583. Walker GW (1967) The clinical use fo Furosemide and Ethacrynic acid. Med Clin North Am 51:1277–1283PubMedGoogle Scholar
  584. Walser M (1961) Calcium clearance as a function of sodium clearance in the dog. Am J Physiol 200:1099–1104PubMedGoogle Scholar
  585. Walter SD (1976) Cardiac actions of kaliuretics and antikaliuretics without digitalis. Am Heart J 92:124–125Google Scholar
  586. Watkins J, Abbott EC, Hensby CN, Webster J, Dollery CT (1980) Attenuation of hypotensive effect of propranolol and thiazide diuretics by indomethacin. Br Med J 281:702–705PubMedGoogle Scholar
  587. Watson LS, van Pelt SM, Winter ChA (1964) Effect of chlorothiazide on blood sugar of rats. Fed Proc 23:438Google Scholar
  588. Weber DJ (1972) Intraveneous triamterene in the treatment of acute digitalis intoxication. Clin Pharmacol Ther 13:868–874PubMedGoogle Scholar
  589. Weidmann P, Meier A, Mordasini R, Riesen W, Bachmann C, Peheim E (1981) Diuretic treatment and serumlipoproteins : Effect of Tielinic acid and Indapamid. Klin Wochenschr 59:343–346PubMedGoogle Scholar
  590. Weiner IM, Mudge GH (1964) Renal tubular mechanisms for excretion of organic acids and bases. Am J Med 36:743–762PubMedGoogle Scholar
  591. Weinman EJ, Ekonoyan G, Suki WN (1975) The influence of extracellular fluid on the tubular reabsorption of uric acid. J Clin Invest 55:283–291PubMedGoogle Scholar
  592. Weiss P, Hersey RM, Dujovne CA, Bianchine JR (1969) The metabolism of amiloride hydrochloride in man. Clin Pharmacol Ther 10:401–406PubMedGoogle Scholar
  593. Weissel W (1962) Klinischer Beitrag zur diabetogenen Wirkung der Saluretika Wien. Z Inn Med 43:389–396Google Scholar
  594. Weller JM, Borondy PE (1965) Effect of benzothiadiazine drugs on carbohydrate metabolism. Metabolism 14:708–714PubMedGoogle Scholar
  595. Weller JM, Borondy M (1967) Effect of Furosemide on glucose metabolism. Metabolism 16:532–536PubMedGoogle Scholar
  596. Weller JM, Borondy M (1969) Inhibitory effect of chlorothiazide on glucose utilization by aorta. Proc Soc Exp Biol Med 132:1064–1066PubMedGoogle Scholar
  597. Welt LG, Young DT, Thorup OA, Burnett CH (1954) Renal tubular phenomena under the influence of a carbonic anhydrase inhibitor. Am J Med 16:612 (Abstr)Google Scholar
  598. Werning C, Baumann K, Schönbeck M, Gysling E, Weidmann P, Siegenthaler W (1969) Die Wirkung länger dauernder Hydrochlorothiazid-Gaben auf die Plasma-Renin-Aktivität und die Aldosteron-Exkretionsrate bei Normalpersonen. Klin Wochenschr 47:318–324PubMedGoogle Scholar
  599. White RJ (1970) Effect of potassium supplements on the exchangeable potassium in chronic heart disease. Br Med J II:141–142Google Scholar
  600. White RJ, Chamberlain DA, Hamer J, McAllister J, Hawkins LA (1969) Potassium depletion in severe heart disease. Br Med J 11:606–610Google Scholar
  601. Widal F, Lemierre A (1903) Pathogénic de certains oedèmes brigthiques: action du chlorure de sodium ingéré. Bull Soc Med (Paris) 20:678Google Scholar
  602. Wiebelhaus VD, Weinstock J, Brennau FT, Sosnowski G, Larsen TJ (1961) A potent, non-steroidal orally active antagonist of aldosterone. Fed Proc 20:409Google Scholar
  603. Wiederholt M, Sullivan WJ, Giebisch G, Solomon AK, Curran PF (1971) Transport of potassium and sodium across single distal tubules of Amphiuma. J Gen Physiol 57:495–529PubMedGoogle Scholar
  604. Wiggins RA, Hutchin ME, Carone JV, Doolan PD (1959) Effect of spirolactone 8109 on renal function in normal human subjects. Proc Soc Exp Biol Med 100:625–627PubMedGoogle Scholar
  605. Wilkins RW (1959) New drugs for the treatment of hypertension. Ann Intern Med 50:1–10PubMedGoogle Scholar
  606. Williams GH, Cain JP, Dluhy RG, Underwood RH (1972) Studies on the control of plasma aldosterone concentration in normal man. J Clin Invest 51:1731–1742PubMedGoogle Scholar
  607. Williamson HE, Bourland WA, Marchand G (1974) Inhibition of ethacrynic acid induced increase in renal blood flow by indomethacin. Prostaglandins 8:297–301PubMedGoogle Scholar
  608. Williamson HE, Marchand GR, Bourland WA, Farley DB, Orden DE van (1976) Ethacrynic acid induced release of prostaglandin E to increase renal blood flow. Prostaglandins 11:519–522PubMedGoogle Scholar
  609. Wilson JR, Reichet N, Dunkman WB, Goldberg S (1981) Effect of diuretics on the performance of the failing left ventricle in man. Am J Med 70:234–239PubMedGoogle Scholar
  610. Windhager EE (1981) Interaktionen zwischen Natrium- und Calciumresorption. In: Krück F, Schrey A (Hrsg) Diuretika II. Wolf, München, S 171–178Google Scholar
  611. Windhager EE, Giebisch G (1976) Proximal sodium and fluid transport. Kidney Int 9:121–133PubMedGoogle Scholar
  612. Withering W (1785) An account of the Foxglove and some of its medical uses: With practical remarks on dropsy and other diseases. Robinson, BirminghamGoogle Scholar
  613. Wolff FW (1969) A structural basis for the hyperglycemic action of diuretics? Biochem Med 2:333–336Google Scholar
  614. Wolff FW, Parmley WW, White K, Okun R (1963) Drug induced diabetes: diabetogenic activity of long term administration of benzothiadiazines. JAMA 185:568–574Google Scholar
  615. Wolff HP (1960) Diuretica in der Behandlung der Herzinsuffizienz. Inernist 1:14–22Google Scholar
  616. Wolff HP, Bette L, Blaise H, Düsterdieck G, Jahnecke J, Kobayaski T, Krück F, Lommer D, Schieffer H (1966) Role of aldosterone in edema formation. NY Acad Sci 139:285–294Google Scholar
  617. Wong N, Quamme GA, Dirks JH (1980) Hypocalciuric action of chlorothiazide (DTZ) in thyroparathyroidectomized (TPTX) hamsters. Fed Proc 39:2356AGoogle Scholar
  618. Wright FS (1977) Sites and mechanisms of potassium transport along the renal tubule. Kidney Int 11:415–432PubMedGoogle Scholar
  619. Wright FS, Schnermann J (1974) Interference with feedback control of glomerular filtration rate by furosemide, triflocin, and cyamide. J Clin Invest 53:1695–1708PubMedGoogle Scholar
  620. Yendt ER (1970) Renal calculi. Can Med Assoc J 102:479–489PubMedGoogle Scholar
  621. Yendt ER, Cohanim M (1977) Use of diuretics in hypercalciuria. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Thieme, Stuttgart, pp 198–201Google Scholar
  622. Yendt ER, Cohanim M (1978) Prevention of calcium stones with thiazides. Kidney Int 13:397–409PubMedGoogle Scholar
  623. Yendt ER, Gague RJA, Cohanim M (1965) The effects of thiazides in idiopathic hypercalciuria. Trans Am Clin Climatol Assoc 77:96–110Google Scholar
  624. Yendt ER, Gagnê RJA, Cohanim M (1966) The effects of thiazides in idiopathic hypercalciuria. Am J Med Sci 251:449–470PubMedGoogle Scholar
  625. Yendt ER, Guay GF, Garcia DA (1970) The use of thiazides in the prevention of renal calculi. Can Med Assoc J 102:614–620PubMedGoogle Scholar
  626. Zatuchni J, Kordasz F (1961) The diabetogenic effect of thiazide. Am J Cardiol 7:565–567Google Scholar
  627. Zehr, Hasbargen JA, Kurz KD (1976) Reflex suppression of renin secretion during distension of cardiopulmonary receptors in dogs. Circ Res 38:232–239PubMedGoogle Scholar
  628. Zicha L, Weist F, Scheiffarth, Schmid E (1964) Dünnschicht-chromatographische Untersuchungen des 3′-(3-Oxo-7-acethylthio-17β-hydroxy-4-androsten-17α-yl) propinsäurey-lactons und seiner Metaboliten beim Menschen. Arzneimittelforsch 14:699–705PubMedGoogle Scholar
  629. Zsotér TT, Suffiad K (1973) Effect of hydrochlorothiazide on calcium kinetics in blood vessels. Can J Physiol Pharmacol 51:579–582PubMedGoogle Scholar
  630. Zsotér TT, Hart F, Radde IC (1970) Mechanism of antihyper tensive action of prolonged administration of hydrochlorothiazide in rabbit and dog. Circ Res 28:717–725Google Scholar
  631. Zsotér TT, Hart F, Radde IC, Endrenyi L (1972) Effect of chlorthalidone on blood vessels. J Pharmacol Exp Ther 180:723–731PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • F. Krück

There are no affiliations available

Personalised recommendations