Neuroblastoma: Recent Developments in Assessment and Management
Not all children with neuroblastoma succumb to the disease. “Good-prognosis”, “intermediate-prognosis” and “bad-prognosis” patients can now be defined; unfortunately, the latter predominate and give the tumour its overall unsavoury reputation. Children with good-prognosis disease are often cured by surgery alone; by contrast there is little evidence to date of a fall in mortality for bad-prognosis patients. However, neuroblastoma is a chemoresponsive and radioresponsive tumour, and the “tail” on the survival curves published for several series of children treated with combination drug therapy indicate that, even for patients with advanced disease, cure is a less than remote possibility.
KeywordsTotal Body Irradiation High Dose Melphalan Vanillyl Mandelic Acid Good Partial Response Occult Tumour Cell
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