The Pathology and Natural History of Childhood Tumours

  • H. B. Marsden
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 88)


In the past few decades cancer has become relatively more important in paediatrics due to the advances in prevention and treatment of infections. In 1970 neoplasia was the second most common cause of death between the ages of 1 and 15 years (Marsden and Steward 1976). The improvement in the results of therapy and the study of aetiological factors have shown that paediatric oncology is a particularly rewarding field. The Children’s Tumour Registry in Manchester1 (MCTR) has kept records of all cases of childhood cancer in the North West region of England since 1954 and has provided the data on which this review is based.


Germ Cell Tumour Renal Tumour Synovial Sarcoma Acute Lymphoid Leukaemia Childhood Tumour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Beckwith JB, Palmer NF (1978) Histology and prognosis of Wilms’ tumour. Results from the first national Wilms’ tumour study. Cancer 41: 1937–1948PubMedCrossRefGoogle Scholar
  2. 2.
    Birch JM, Marsden HB, Swindell R (1980) Incidence of malignant disease in childhood: a 24-year review of the Manchester Children’s Tumour Registry data. Br J Cancer 42: 215–223PubMedCrossRefGoogle Scholar
  3. 3.
    Dura WT, Gladkowska-Dura MJ, Johnson WW (1981) Non-Hodgkin’s lymphoma in the first two decades. Morphologic and immunocytochemical study. Virchows Archiv [Pathol Anat] 390: 23–62CrossRefGoogle Scholar
  4. 4.
    Evans AE, D’Angio GJ, Gerson JM, Robinson J. Schnaufer L (1980) A review of IV-S neuroblastoma patients at the Children’s Hospital of Philadelphia. Cancer 45: 833–839PubMedCrossRefGoogle Scholar
  5. 5.
    Gonzalez-Crussi F, Wiederhold MD, Sotelo-Avila C (1980) Congenital fibrosarcoma. Presence of a histiocytic component. Cancer 46: 77–86PubMedCrossRefGoogle Scholar
  6. 6.
    Gonzalez-Crussi F, Sotelo-Avila C, Kidd JM (1981) Mesenchymal renal tumours in infancy: a reappraisal. Hum Pathol 12: 78–85PubMedCrossRefGoogle Scholar
  7. 7.
    Haas JE, Palmer NF, Weinberg AG, Beckwith JB (1981) Ultrastructure of malignant rhabdoid tumour of kidney. Hum Pathol 12: 646–657PubMedCrossRefGoogle Scholar
  8. 8.
    Hughes M, Marsden HB, Palmer MK (1974) Neuroblastoma — relation of histology to prognosis and clinical staging. Cancer 34: 1706–1711PubMedCrossRefGoogle Scholar
  9. 9.
    Lawler W, Marsden HB, Palmer MR (1975) Wilms’ tumour — histologic variation and prognosis. Cancer 36: 1122–1126PubMedCrossRefGoogle Scholar
  10. 10.
    Lennert K, Stein H, Kaiserling E (1975) Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer 31 (Suppl II): 29–35Google Scholar
  11. 11.
    Llombart-Bosch A. Blache R, Peydro-Olaya A (1978) Ultrastructural study of 28 cases of Ewing’s sarcoma: typical and atypical forms. Cancer 41: 1362–1373PubMedCrossRefGoogle Scholar
  12. 12.
    Lukes RJ, Collins RD (1975) New approach to the classification of lymphomata. Br J Cancer (Suppl II ) 31: 1–28Google Scholar
  13. 13.
    Marsden HB (1963) Clinical and pathological features of neuroblastoma. In: Varley H, Gowenlock AH (eds) The clinical chemistry of monoamines, Elsevier Publishing Company, Amsterdam London New YorkGoogle Scholar
  14. 14.
    Marsden HB The pathology of soft tissue sarcomas. In: D’Angio G, Evans AE (eds) Bone and soft tissue sarcomas. Edward Arnold, London (in press)Google Scholar
  15. 15.
    Marsden HB, Steward JK (1964) Ewing’s tumour and neuroblastoma. J Clin Pathol 17: 411–417PubMedCrossRefGoogle Scholar
  16. 16.
    Marsden HB, Steward JK (eds) (1976) Tumours in children. Springer, Berlin Heidelberg New YorkGoogle Scholar
  17. 17.
    Marsden HB, Lennox EL, Lawler W, Kinnier-Wilson LM (1980) Bone metastases in childhood renal tumours. Br J Cancer 41: 875–879PubMedCrossRefGoogle Scholar
  18. 18.
    Marsden HB, Lawler W (1980) Bone-metastasizing renal tumour of childhood. Histopathological and clinical review of 38 cases. Virchows Archiv [Pathol Anat] 387: 341–351CrossRefGoogle Scholar
  19. 19.
    Marsden HB, Birch JM, Swindell R (1981) Germ cell tumours of childhood: a review of 137 cases. J Clin Pathol 34: 879–883PubMedCrossRefGoogle Scholar
  20. 20.
    Mickelson MR, Brown SA, Maynard JA, Cooper RR, Bonfiglio M (1980) Synovial sarcoma. An EM study of monophasic and biphasic forms. Cancer 45: 2109–2118PubMedCrossRefGoogle Scholar
  21. 21.
    Miller RW, Fraumeni JF Jr, Hill JA (1968) Neuroblastoma: epidemiologic approach to its origin. Am J Dis Child 115: 253–261PubMedGoogle Scholar
  22. 22.
    Ojeda VJ, Jacobsen PF, Papadimitriou JM (1980) Primary cerebral neuroblastoma. Case report with light microscopy, tissue culture and EM study. Pathology 12: 269–274PubMedCrossRefGoogle Scholar
  23. 23.
    Pollak ER, Miller JH, Vye MV (1981) Medulloblastoma presenting as leukaemia. Am J Clin Pathol 76: 98–103Google Scholar
  24. 24.
    Romansky SG, Crocker DW, Shaw KNF (1978) Ultrastructural studies on neuroblastoma. Cancer 42: 2392–2398PubMedCrossRefGoogle Scholar
  25. 25.
    Sawada T, Suginoto TS, Tazawa M, Takada H, Kusunoki T (1979) Serum immunoglobulin levels in patients with neuroblastoma and their prognosis. J Pediat Surg 14: 405–413PubMedCrossRefGoogle Scholar
  26. 26.
    Stout AP (1948) Myxoma. The tumor of primitive mesenchyme. Mesenchymoma, the mixed tumor of mesenchymal derivatives. Ann Surg 127: 278–290CrossRefGoogle Scholar
  27. 27.
    Watson AR, Evans DIK, Marsden HB, Miller V, Rogers PA (1981) Purine nucleoside phosphorylase deficiency associated with a fatal lymphoproliferative disorder. Arch Dis Child 56: 563–565PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1983

Authors and Affiliations

  • H. B. Marsden
    • 1
  1. 1.Department of PathologyUniversity of Manchester and Royal Manchester Children’s HospitalManchesterUK

Personalised recommendations