Benefits and Complications of Combined Management of Children with Malignant Disease

  • D. Pearson
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 88)


The modern management of children with malignant diesease requires the close cooperation of the radiotherapist and chemotherapist with surgeons of several disciplines. The clinicians so involved need to be aware of both the benefits and complications which may arise from the combination of the different treatment modalities. Tumours are rare in children; so it is essential that the expertise gathered together for the management of the patients should be in reasonably large oncology centres and also that there is cooperation at both national and international levels to maximise the benefits of treatment.


Late Effect Growth Hormone Deficiency Combine Management Embryonal Rhabdomyosarcoma Testicular Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bamford FM, Morris Jones PH, Beardwell CG, Ribiero GG, Shalet SM, Pearson D (1976) Residual disabilities in children treated for intra-cranial space-occupying lesions. Cancer 37: 1149–1151PubMedCrossRefGoogle Scholar
  2. 2.
    Chapman JA, Deakin DP, Green GH (1980) Slipped upper femoral epiphysis after radiotherapy. J Bone Joint Surg 62: 337–339Google Scholar
  3. 3.
    D’Angio GH, Farber S, Maddock CL (1959) Potentiation of x-ray effects by actinomycin D. Radiology 73: 175PubMedGoogle Scholar
  4. 4.
    D’Angio GJ, Meodows A, Miké V, Harris C, Evans A, Jaffe N, Newton W, Schweisguth O, Sutow W, Morris-Jones P (1976) Decreased risk of radiation-associated second malignant neoplasms in actinomycin D treated patients. Cancer (Suppl) 37: 1177–1185Google Scholar
  5. 5.
    Pearson D, Deakin DP, Hendry JH, Moore JV (1978) The interaction of actionomycin D and radiation. Int J Radiat Oncol Biol Phys 4: 71–73PubMedGoogle Scholar
  6. 6.
    Shalet SM, Beardwell CG, Morris Jones PH, Pearson D (1976) The effect of varying doses of cerebral irradiation on growth hormone production in children. Clin Endocrinol 5: 287–290CrossRefGoogle Scholar
  7. 7.
    Shalet SM, Rosenstock JD, Beardwell CG, Morris Jones PH, Pearson D (1977) Thyroid dysfunction following external irradiation to the neck for Hodgkin’s disease in childhood. Clin Radiol 28: 511–515PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1983

Authors and Affiliations

  • D. Pearson
    • 1
  1. 1.Department of Radiotherapy and OncologyChristie Hospital and Holt Radium InstituteManchesterUK

Personalised recommendations