Abstract
Soft tissue sarcomas occur throughout childhood. By far the commonest is rhabdomyosarcoma, but undifferentiated embryonal sarcomas, fibrosarcomas, liposarcomas and synovial sarcomas may occur. Rhabdomyosarcoma accounts for more than 10% of childhood malignant solid tumours, and was seen in 11.3% of 612 successive children treated by the Royal Marsden Hospital and St Bartholomew’s Hospital Children’s Solid Tumour Group. It is being used as a model for development of treatment of other soft tissue sarcomas, and it will form the main subject of this chapter.
The patients presented in this report have been under the care of Dr. J. E. Freeman, Dr. J. Graham-Pole and Dr. E. R. Sandland. Dr. A. G. Stansfeld has been responsible for the histological diagnosis, and I have been much helped by Dr. J. Kingston in reviewing the data. Mr D. Hughes of the Research Centre for Mathematical Modelling of Clinical Trials at Warwick University has provided the actuarial curves. I am grateful to Jo Barton for typing the manuscript Soft Tissue Sarcomas in Children
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Green DM, Jaffe N (1978) Progress and controversy in the treatment of childhood rhabdomyosarcoma. Cancer Treat Rev 5: 7–23
Li FP, Fraumeni JF (1979) Soft tissue sarcomas, breast cancer and other neoplasms. A familial syndrome? Ann Intern Med 71: 747–752
Malek RS, Kelalis PP (1977) Paratesticular rhabdomyosarcoma in childhood. J Urol 118: 450–453
Malpas JS, Freeman JE, Paxton AM, Walker-Smith J, Stansfeld AG, Wood CBS (1976) Radiotherapy and adjuvant combination chemotherapy for childhood rhabdomyosarcoma. Br Med J 1: 247–249
Maurer HM, Moon I, Donaldson M, Fernandez C, Gehan EA, Hammond D, Hays DM, Lawrence W, Newton W, Ragab A, Raney B, Soule EH, Sutow WW, Tefft M (1977) Intergroup rhabdomyosarcoma study: preliminary report. Cancer 40: 2015–2026
Pinkel D, Pickren J (1961) Rhabdomyosarcoma in children. J Am Med Assoc 175: 293–298
Pratt CB, Hustu HO, Fleming ID, Pinkel D (1972) Co-ordinated treatment of childhood rhabdomyosarcoma with surgery, radiotherapy and combination chemotherapy. Cancer Res 32: 606–610
Pratt CB, George S (1980) Response of childhood rhabdomyosarcoma (RMS) to combination chemotherapy. Proc Am Assoc Cancer Res (Abstr 723 ) 21: 181
Ransom JL, Pratt CB, Shanks E (1977) Childhood rhabdomyosarcoma of extremity. Results of combined modality therapy. Cancer 40: 2810–2816
Tefft M, Fernandez C, Donaldson M, Newton W, Moon TF (1978) Incidence of meningeal involvement by rhabdomyosarcoma of the head and neck in children. Report of Intergroup Rhabdomyosarcoma Study. Cancer 42: 253–258
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Malpas, J.S. (1983). Soft Tissue Sarcomas in Children. In: Duncan, W. (eds) Paediatric Oncology. Recent Results in Cancer Research, vol 88. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82034-2_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-82034-2_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82036-6
Online ISBN: 978-3-642-82034-2
eBook Packages: Springer Book Archive