Detection of Endocrine Responsiveness by Flow Cytometric DNA Analysis in Experimental Human Breast Cancer

  • N. Brünner
  • M. Spang-Thomsen
  • L. Vindeløv
  • A. Nielsen
  • S. A. Engelholm
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 90)

Abstract

In human metastatic breast cancer, the response to endocrine therapy is approximately 30%, regardless of type of endocrine therapy applied (McGuire et al. 1975). Mainly based on this observation, it has been suggested that different kinds of endocrine treatment share the same ultimate mode of action (Rose 1982). However, in recent years it has been shown that different endocrine treatment modalities do not always show cross-resistance (Smith et al. 1982, Murray and Pitt 1982), suggesting different modes of action.

Keywords

Estrogen Shrinkage Iodide Tamoxifen Progesterone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • N. Brünner
    • 1
  • M. Spang-Thomsen
    • 1
  • L. Vindeløv
    • 1
  • A. Nielsen
    • 1
  • S. A. Engelholm
    • 1
  1. 1.The University Institute of Pathological AnatomyUniversity of CopenhagenCopenhagenDenmark

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