Skip to main content

Fluorescence-Histochemical and Electron-Microscopical Investigations in Melanoma Patients After Isolated Cytostatic Perfusion

  • Chapter
Vascular Perfusion in Cancer Therapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 86))

  • 87 Accesses

Abstract

In the light-microscopic examination of melanoma metastases with heavily damaged tumor cells after isolated cytostatic perfusion it is often difficult to decide whether the therapy has completely destroyed all tumor cells or has only partly affected them. It must be assumed that viable tumor cells resistant to therapy may be the source of repeated tumor growth, i.e., relapse of further spreading of tumor cells.

The authors are grateful to Dr. S. Syed Ali, at the Center of Anatomy and Cytobiology for assistance in ultrastructural studies, and to Mrs. G. Thiele, at the Department of Clinical and Experimental Dermatology, for skilled technical assistance. We are indebted to Prof. Dr. Dr. h.c. A. Oksche and Prof. Dr. R. Lange, at the Center of Anatomy and Cytobiology, for the provision of a work place

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Björklund A, Falck B, Owman C (1972) Fluorescence-microscopic and microspectrofluorometric techniques for the cellular localization and characterization of biogenic amines. In: Kopin J (ed) Methods of investigative and diagnostic endocrinology. North Holland, Amsterdam

    Google Scholar 

  • David H, Uerlinge J, Grupe M (1971) Strukturveränderungen von Leberzellen bei supranormalen Temperaturen. Exp Pathol 5: 2–10

    CAS  Google Scholar 

  • Dietzel F (1975) Tumor und Temperatur. Urban and Schwarzenberg, München

    Google Scholar 

  • Falck B, Hillarp N-A, Thieme G, Torp A (1962) Fluorescence of catecholamines and related compounds condensed with formaldehyde. J Histochem Cytochem 10: 348–354

    Article  CAS  Google Scholar 

  • Häkanson R, Sundler F (1974) Formaldehyde condensation at reduced temperature. Increased sensitivity and specificity of the fluorescence-microscopic method for demonstrating primary catecholamines. J Histochem 22: 887–894

    Google Scholar 

  • Harisiadis L, Hall EJ, Kraljevic U, Borek C (1975) Hyperthermia: biological studies at the cellular level. Radiation Biology 117: 447–452

    CAS  Google Scholar 

  • Illig L, Aigner K (1980) Therapie des malignen Melanoms unter besonderer Berücksichtigung der isolierten Extremitätenperfusion. Dtsch Ärzteblatt 77: 2911–2925

    Google Scholar 

  • Illig L, Paul E (1976) Unspezifische Immuntherapie des malignen Melanoms der Haut mit DNCB nach Malek-Mansour. Hautarzt 27: 579–587

    PubMed  CAS  Google Scholar 

  • Kerr JFR, Searle J (1980) Apoptosis: its nature and kinetic role. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research, Raven, New York pp 367–384

    Google Scholar 

  • Krementz ET, Creach O Jr (1970) Advances in the treatment of malignant melanoma. Proc Natl Canc Conf 6: 529–542

    CAS  Google Scholar 

  • Morgan LR Jr, Samuels MS, Carter RD, Krementz ET (1976) Effects of dimethyltriazeno imidazole carboxamide (DTIC; NSC 45, 388) on melanoma metabolites and enzymes. Pigment cell 2. Karger, Basel, 327–338

    Google Scholar 

  • Paul E, Hartwig H-G, Möller W, Illig L (1975a) Fluoreszenzhistochemische Untersuchungen und mikrofluorometrische Analysen an pigmentbildenden Tumoren der Haut (unter besonderer Berücksichtigung der Melanom-Theorie von Mishima). Arch Dermatol Res 253: 125–144

    Article  PubMed  CAS  Google Scholar 

  • Paul E, Illig L, Möller W (1975b) Vitalitätsbeurteilung von Metastasen eines malignen Melanoms nach endolymphatischer Radionuklidtherapie mit der Falck-Hillarp-Methode. Hautarzt 26: 317–320

    PubMed  CAS  Google Scholar 

  • Rorsman H (1974) The melanocyte illuminated. Trans St John’s Hosp Derm Soc 60: 135–141

    CAS  Google Scholar 

  • Schraffordt Koops H, Oldhoff J, van der Ploeg E, Vermey A, Eibergen R, Beekhuis H (1977) Some aspects of the treatment of primary malignant melanoma of the extremities by isolated regional perfusion. Cancer 39: 27–33

    Article  PubMed  CAS  Google Scholar 

  • Stehlin JS Jr, Giovanelly BC, de Ipolyi RD, Muenz LR, Anderson RF (1975) Results of hyperthermic perfusion for melanoma of the extremities. Surg Gynecol Obstet 140: 338–349

    Google Scholar 

  • Strom R, Santoro AS, Crifo C, Bozzi A, Mondovi B, Rossi-Fanelli A (1973) The biochemical mechanism of selective heat sensitivity of cancer cells. Inhibition of RNA synthesis. Eur J Cancer 9: 103–112

    Article  PubMed  CAS  Google Scholar 

  • Tonak J (1981) Die hypertherme Zytostatikaperfusion beim malignen Melanom. Eine experimentelle und klinische Untersuchung. In: Nagel G, Sauer R, Schreiber HW (eds) Zuckschwerdt, München

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Paul, E., Ishii, M., Aigner, K., Hild, P., Illig, L. (1983). Fluorescence-Histochemical and Electron-Microscopical Investigations in Melanoma Patients After Isolated Cytostatic Perfusion. In: Schwemmle, K., Aigner, K. (eds) Vascular Perfusion in Cancer Therapy. Recent Results in Cancer Research, vol 86. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82025-0_41

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-82025-0_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82027-4

  • Online ISBN: 978-3-642-82025-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics