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Role of Extent and Persistence of DNA Modifications in Chemical Carcinogenesis by Aromatic Amines

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Modified Nucleosides and Cancer

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Abstract

Numerous known and suspected human carcinogens belong to the chemical class of aromatic amines, among them many compounds used extensively in industrial processes and in the manufacture of drugs, pesticides, and plastics. Industrial bladder cancer has been attributed primarily to exposure to aromatic amines; this group of compounds has therefore received considerable attention. Particular problems are the wide variety of species and the tissue specificity elicited by these compounds in experimental systems, and much effort has been devoted in the past to identifying the common properties of aromatic amines and explaining specific effects.

Work carried out in the author’s laboratory was supported by the Deutsche Forschungsgemeinschaft

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Abbreviations

AAF:

2-N-acetylaminofluorene

AF:

2-aminofluorene

trans-AAS:

trans-4-N-acetylaminostilbene

trans-DAS:

trans-4-N-acetylaminostilbene

DDT:

1,1,1,-trichloro-2,2-bis-(p-chloro-phenyl)-ethane

TPA:

phorbol-12-tetradecanoyl-13-acetyl-diester

Ade-N6 :

adenine-N 6 derivative

Gua-C-8:

guanine-C-8 derivative

Gua-N2 :

guanine-N2 derivative

Gua-O6 :

guanine-O6 derivative

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Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacherstrasse 9, 8700, Würzburg, Germany

    H.-G. Neumann

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  1. H.-G. Neumann
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  1. Zentrallaboratorium für Mutagenitätsprüfung, Deutschen Forschungsgemeinschaft, Breisacher Strasse 33, D-7800, Freiburg, Germany

    Gisela Nass

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© 1983 Springer-Verlag Berlin • Heidelberg

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Neumann, HG. (1983). Role of Extent and Persistence of DNA Modifications in Chemical Carcinogenesis by Aromatic Amines. In: Nass, G. (eds) Modified Nucleosides and Cancer. Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81947-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-81947-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81949-0

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