Formation and Removal of Methylated Nucleosides in Nucleic Acids of Mammalian Cells
This chapter compares the formation, turnover, and possible functions of methylated nucleosides present in nucleic acids under normal conditions and after exposure to alkylating agents. No attempt is made to provide a totally comprehensive review of the occurrence and biochemistry of such products. Many recent reviews have covered portions of this field, and to summarize such a broad area is probably impossible and unlikely to be useful. More relevantly, it is also outside the limited capabilities of the author. Attention, therefore, is concentrated on the methylation of DNA by certain carcinogens which may have environmental importance and on selected references to certain areas of the immense biochemical literature relating to normal cellular methylations.
KeywordsPyrimidine Aflatoxin Hydrazine Purine Cytosine
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