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Ethionine-Induced Alterations of tRNA Metabolism

  • S. J. Kerr
Part of the Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer book series (RECENTCANCER, volume 84)

Abstract

Ethionine, the ethyl analog of methionine, is a hepatoearcinogen when administered chronically in the diet to rats (Farber 1963). Studies with radioactive ethionine revealed that tRNA was the most extensively labeled nucleic acid species after ethionine administration (Farber et al. 1967). Further studies in recent years have led to extremely interesting findings concerning the effect of ethionine on tRNA metabolism.

Keywords

Ethyl Methanesulphonate Methionine Adenosyltransferase tRNA Species Isozyme Form Methyl Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

SAM

S-adenosylmethionine

SAH

S-adenosylhomocysteine

SAE

S-adenosyletMonine

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Copyright information

© Springer-Verlag Berlin • Heidelberg 1983

Authors and Affiliations

  • S. J. Kerr
    • 1
  1. 1.Department of Biochemistry, Biophysics, and GeneticsUniversity of Colorado, Health Sciences CenterDenverUSA

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