Ethionine-Induced Alterations of tRNA Metabolism

  • S. J. Kerr
Part of the Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer book series (RECENTCANCER, volume 84)


Ethionine, the ethyl analog of methionine, is a hepatoearcinogen when administered chronically in the diet to rats (Farber 1963). Studies with radioactive ethionine revealed that tRNA was the most extensively labeled nucleic acid species after ethionine administration (Farber et al. 1967). Further studies in recent years have led to extremely interesting findings concerning the effect of ethionine on tRNA metabolism.


Ethyl Methanesulphonate Methionine Adenosyltransferase tRNA Species Isozyme Form Methyl Metabolism 
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Copyright information

© Springer-Verlag Berlin • Heidelberg 1983

Authors and Affiliations

  • S. J. Kerr
    • 1
  1. 1.Department of Biochemistry, Biophysics, and GeneticsUniversity of Colorado, Health Sciences CenterDenverUSA

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