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Alteration of Enzymatic DNA Methylation by Chemical Carcinogens

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Modified Nucleosides and Cancer

Abstract

Experiments analyzing the methylation patterns in the vicinity of various eukaryotic genes in gamete DNA and in DNA of various differentiated cells of one organism have shown that during development, the fully methylated zygote DNA becomes devoid of 5-methylcytosines at certain sequences (McGhee and Ginder 1979; Kuo et al. 1979; Mandel and Chambon 1979; Shen and Maniatis 1980; van der Ploeg and Flavell 1980; Weintraub et al. 1981; Groudine and Weintraub 1981). Although there are no gross changes of enzymatic DNA methylation during development and cellular differentiation (Baur et al. 1979; Fabricant et al. 1979; Pollock et al. 1978; Singer et al. 1979; Lapeyre et al. 1980), it was shown that such a hypomethylation correlates with the expression of these particular genes (McGhee and Ginder 1979; Kuo et al. 1979; Mandel and Chambon 1979; Shen and Maniatis 1980; van der Ploeg and Flavell 1980; Weintraub et al. 1981; Groudine and Weintraub 1981; Boehm and Drahovsky 1981a; Chistman et al. 1977; Christman et al. 1980; Boehm and Drahovsky 1981).

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Authors and Affiliations

  1. Zentrum der Biologischen Chemie, Universität Frankfurt, Theodor-Stern-Kai 7, D-6000, Frankfurt a. M. 70, Germany

    T. L. J. Boehm & D. Drahovsky

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  1. T. L. J. Boehm
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  2. D. Drahovsky
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  1. Zentrallaboratorium für Mutagenitätsprüfung, Deutschen Forschungsgemeinschaft, Breisacher Strasse 33, D-7800, Freiburg, Germany

    Gisela Nass

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Boehm, T.L.J., Drahovsky, D. (1983). Alteration of Enzymatic DNA Methylation by Chemical Carcinogens. In: Nass, G. (eds) Modified Nucleosides and Cancer. Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81947-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-81947-6_16

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