Abstract
2-(N-acetoxyacetylamino)fluorene (AcO-AAF), a model of ultimate carcinogen of 2-(acetylamino)fluorene (AAF), reacts with DNA to give essentially N-(deoxygua-nosine-8-yl)AAF (for a review, see Grunberger and Weinstein 1979). This substitution induces a conformational change in the vicinity of the adduct, leading to a local denaturation of the double helix (Daune and Fuchs 1976).
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Pfohl-Leszkowicz, A., Fuchs, R.P.P., Keith, G., Dirheimer, G. (1983). Enzymatic Methylation of Chicken Erythrocyte DNA Modified by Two Carcinogens, 2-(N-Acetoxyacetylamino) Fluorene and Methylnitrosourea. In: Nass, G. (eds) Modified Nucleosides and Cancer. Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81947-6_14
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DOI: https://doi.org/10.1007/978-3-642-81947-6_14
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