Pharmacokinetic Modeling and the Teratologist

  • J. F. Young
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 65)


Pharmacokinetics has proven to be an exceptional tool in pharmaceutical and pharmacologic research. Its development has enhanced the capabilities of providing optimum dosing schedules and formulations for delivery of ethical drugs by relating blood levels of a particular drug to its therapeutic efficacy. Likewise, perturbations in the pharmacokinetic parameters of a compound produced by interactions with a second chemical or with fiver or kidney insufficiency, for example, have provided a more logical basis for the study of drug-drug or drug-chemical interactions, as well as effects of disease states in clinical pharmacology.


Central Compartment Elimination Rate Constant Peripheral Compartment Absorption Rate Constant Deep Compartment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1983

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  • J. F. Young

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