Abstract
Behavioral teratology represents an integration of teratology with experimental psychology, and is primarily concerned with the study of neurobehavioral changes that result from exposure of germ cells, embryos, fetuses, and immature postnatal individuals to a variety of environmental disturbances and events. Like its parent discipline, teratology, these include drugs, industrial chemicals, pesticides, food additives and preservatives, and environmental pollutants, as well as irradiation, stress, infectious agents, and endocrine and metabolic disturbances (Wilson 1973). Its major objective is the description of the behavioral effects induced by these conditions and an understanding of the embryopathic mechanisms by which they are produced. I should emphasize, however, the current state of behavioral teratology as a fledgling discipline; its subject matter remains largely unexplored and uncharted, its methodology has been uneven and occasionally wanting, and its accomplishments strike a tenuous balance between false starts and palpable inroads made by a few pioneering researchers. But despite its immaturity and tentative beginnings, there should be no doubt that it is emerging as a new scientific specialty.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abel EL (1980) The fetal alcohol syndrome: behavioral teratology. Psychol Bull 87:29–50
Bartolome J, Seidler FJ, Anderson TR, Slotkin TA (1976) Effects of prenatal reserpine administration on development of rat adrenal medulla and central nervous system. J Pharmacol Exp Ther 197:293–302
Blinick G, Jerez E, Wallach RC (1973) Methadone maintenance, pregnancy and progency. JAMA 225:477–479
Butcher RE, Brunner RL, Roth T, Kimmel CA (1972 a) A learning impairment associated with maternal hypervitaminosis-A in rats. Life Sci 11:141–145
Butcher RE, Vorhees CV, Kimmel C (1972 b) Learning impairment from maternal salicylate treatment in rats. Nature New Biol 236:211–212
Butcher RE, Scott WJ, Kazmaier K, Ritter EJ (1973) Postnatal effects in rats of prenatal treatment with hydroxyurea. Teratology 7:161–165
Butcher RE, Hawver K, Burbacher T, Scott W (1975) Behavioral effects from antenatal exposure to teratogens. In: Ellis NR (ed) Aberrant development in infancy: human and animal studies. L Erlbaum, Hillside NJ, pp 161–167
Carr JN (1975) Drug patterns among drug-addicted mothers: incidence in use, and effects on children. Pediatr Ann 4:65–77
Chambers CD, Griffey MS (1975) Use of legal substances within the general population: the sex and age variables. In: Harbison RD (ed) Perinatal addiction. Spectrum, Hollis-wood NY, pp 7–19
Clark VH, Gorman D, Vernadakis, A (1970) Effects of prenatal administration of psychotropic drugs on behavior of developing rats. Dev Psychobiol 3:225–235
Clarren SK, Alvord EC, Sumi SM, Streissguth AP, Smith DW (1978) Brain malformations related to prenatal exposure to ethanol. J Pediatr 92:64–67
Cooper JE, Cummings AJ, Jones H (1977) The placental transfer of phencyclidine in the pig: plasma levels in the sow and its piglets [Abstr]. J Physiol 267:17P–18P
Desmond MM, Schwanecke RP, Wilson GS, Yasunaga S, Burgdorff I (1972) Maternal barbiturate utilization and neonatal withdrawal symptomatology. J Pediatr 80:190–197
Dinges DF, Davis MM, Glass P (1980) Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance. Sience 209:619–621
Fowler H, Hicks SP, D’Amato CJ, Beach FA (1962) Effects of fetal irradiation on behavior in the albino rat. J Comp Physiol Psychol 55:309–314
Friedler G, Cochin J (1972) Growth retardation in offspring of female rats treated with morphine prior to conception. Science 175:654–656
Gauron EF, Rowley VN (1969) Effects on offspring behavior of mothers’ early chronic drug experience. Psychopharmacologia 16:5–15
Geber WF, Schramm LC (1969) Comparative teratogenicity of morphine, heroin and methadone in the hamster [Abstr]. Pharmacology 11:248
German JA, Kowal A, Ehlers KH (1970) Trimethadione and human teratogenesis. Teratology 3:349–362
Golden NL, Sokal RJ, Rubin IL (1980) Angel dust: possible effects on the fetus. Pediatrics 65:18–20
Goodfriend WJ, Shey IA, Klein MD (1956) The effects of maternal narcotics addiction in the newborn. Am J Obstet Gynecol 71:29–36
Hanson JW, Smith DW (1975) The fetal hydantoin syndrome. J Pediatr 87:285
Hanson JW, Jones KL, Smith DW (1976 a) Fetal alcohol syndrome: Experience with 41 patients. JAMA 235:1458–1460
Hanson JW, Myrianthopoulos NC, Sedgwick-Harvey MA, Smith DW (1976b) Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. J Pediatr 89:662–668
Hicks SP, D’Amato CJ (1966) Effects of ionizing radiation on mammalian development. In: Wollam DHM (ed) Advances in teratology. Logos Press, London, pp 195–250
Hutchings DE (1978) Behavioral teratology: embryopathic and behavioral effects of drugs during pregnancy. In: Gottlieb G (ed) Various influences on brain and behavioral development. Academic Press, New York
Hutchings DE, Gaston J (1974) The effects of vitamin A excess administered during the mid-fetal period on learning and development in rat offspring. Dev Psychobiol 7:225–233
Hutchings DE, Gibbon J, Kaufman M (1973) Maternal vitamin A excess during the early fetal period. Effects on learning and development in offspring. Dev Psychobiol 6:445–447
Hutchings DE, Hunt HF, Towey JP, Rosen TS, Gorinson HS (1976) Methadone during pregnancy in the rat: dose level effects on maternal and perinatal mortality and growth in the offspring. J Pharmacol Exp Ther 197:171–179
Hutchings DE, Feraru E, Gorinson HS, Golden RR (1979 a) Effects of prenatal methadone on the rest-activity cycle of the pre-weanling rat. Neurobehav Toxicol 1:33–40
Hutchings DE, Towey JP, Gorinson HS, Hunt HF (1979 b) Methadone during pregnancy: assessment of behavioral effects in the rat offspring. J Pharmacol Exp Ther 208:106–112
Isaacson RL (1974) The limbic system. Plenum Press, New York
Joffe JM (1969) Prenatal determinants of behavior. Pergamon Press, Oxford
Jones KL, Smith DW (1975) The fetal alcohol syndrome. Teratology 12:1–10
Jones KL, Smith DW, Ulleland CW, Streissguth AP (1973) Pattern of malformation in offspring of chronic alcoholic women. Lancet 1:1267–1271
Jones KL, Smith DW, Streissguth AP, Myrianthopoulos NC (1974) Outcome in offspring of chronic alcoholic women. Lancet 1:1076–1078
Kalter H (1968) Teratology of the central nervous system. University of Chicago Press, Chicago
Kandall SR (1977) Late complications in passively addicted infants. In: Rementeria JL (ed) Drug abuse in pregnancy and neonatal effects. CV Mosby, St Louis, pp 116–128
Langman J, Welch GW (1967) Excess vitamin A and development of the cerebral cortex. J Comp Neurol 131:15–26
Langman J, Webster W, Rodier P (1975) Morphological and behavioral abnormalities caused by insults to the CNS in the perinatal period. In: Berry CL, Poswillo DE (eds) Teratology: trends and applications. Springer, Berlin Heidelberg New York, pp 182– 200
Levitt M, Hutchings DE, Bodnarenko SR, Leicach LL (1982) Postnatal persistence of methadone following prenatal exposure in the rat. Neurobehav Toxicol Teratol 4:383–385
Lipsitz PJ, Blatman S (1974) Newborn infants of mothers on methadone maintenance. NY State J Med X:994–999
Lodge A (1976) Developmental findings with infants born to mothers on methadone maintenance: a preliminary report. In: NIDA: Symposium on comprehensive health care for addicted families and their children, May 20–21, 1976. pp 79–85
Lydiard RB, Sparber SB (1974) Evidence for a critical period for postnatal elevation of brain tyrosine hydroxylase activity resulting from reserpine administration during embryonic development. J Pharmacol Exp Ther 189:370–379
Marble RD, Thomas RG, Sterling ML (1980) Screening for angel dust in newborns. Peda-trics 66:334
Markham JK, Emmerson JL, Owen NV (1971) Teratogenicity studies of methadone HCL in rats and rabbits. Nature 233:342–343
Marks TA, Worthy WC, Staples RE (1980) Teratogenic potential of phencyclidine in the mouse. Teratology 21:241–246
McFie J, Robertson J (1973) Psychological test results of children with thalidomide deformities. Dev Med Child Neurol 15:719–727
Middaugh LD, Simpson LW (1980) Prenatal maternal methadone effects on pregnant C57BL/6 mice and their offspring. Neurobehav Toxicol 2:307–313
Middaugh LD, Blackwell LA, Santos CA III, Zemp JW (1974) Effects of d-amphetamine sulfate given to pregnant mice on activity and on catecholamines in the brains of offspring. Dev Psychobiol 7:429–438
Middaugh LD, Santos CA III, Zemp JW (1975 a) Effects of phenobarbital given to pregnant mice on behavior of mature offspring. Dev Psychobiol 8:305–313
Middaugh LD, Santos CA III, Zemp JW (1975 b) Phenobarbital during pregnancy alters operant behavior of offspring in C57BL/6J mice. Pharmacol Biochem Behav 3:1137–1139
Persinger MA (1971) Pre-and neonatal exposure to 1019 Hz and 0.5 Hz electromagnetic fields and delayed conditioned approach behavior. Ph.D. dissertation, University of Manitoba
Peters MA (1977) The effect of maternally administered methadone on brain development in the offspring. J Pharmacol Exp Ther 203:340–346
Pierog S, Chandarasu O, Wexler I (1977) Withdrawal symptoms in infants with the fetal alcohol syndrome. J Pediatr 90:630–633
Ramer CM, Lodge A (1975) Clinical and developmental characteristics of infants of mothers on methadone maintenance. Addict Dis 2:227–234
Rech RH, Lomuscio G, Algeri S (1980) Methadone exposure in utero: effects on brain biogenic amines and behavior. Neurobehav Toxicol 2:75–78
Rodier PM (1980) Chronology of neuron development: animal studies and their clinical implications. Child Neurol 22:525–545
Rodier PM, Webster W, Langman J (1975) Morphological and behavioral consequences of chemically induced lesions of the CNS. In: Ellis NR (ed) Aberrant development in infancy: human and animal studies. L Erlbaum, Hillsdale NJ, pp 169–176
Rosen TS, Pippenger CE (1976) Pharmacological observations on the neonatal withdrawal syndrome. J Pediatr 88:1044
Rosett HL, Sander LW (1979) Effects of maternal drinking on neonatal morphology and state regulation. In: Osofsky JD (ed) Handbook of infant development. Wiley, New York, pp 809–836
Schulman CA (1969) Alterations of the sleep cycle in heroin-addicted and “suspect” newborns. Neuropadiatrie 1:89–100
Shapiro S, Hartz SC, Siskind V et al. (1976) Anticonvulsants and parental epilepsy in the development of birth defects. Lancet 1:272–275
Shaywitz SE, Cohen DJ, Shaywitz BA (1980) Behavior and learning difficulties in children of normal intelligence born to alcoholic mothers. J Pediatr 96:978–982
Shenefelt RE (1972) Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment. Teratol 5:103–118
Sisson TRC, Wickler M, Tsai P, Rao IP (1974) Effect of narcotic withdrawal on neonatal sleep patterns. Pediatr Res 8:451
Slotkin TA, Law C, Bartolome M (1976) Effects of neonatal or maternal methadone administration on ornithena decarboxylase activity in brain and heart of developing rats. J Pharmacol Exp Ther 199:141–148
Sobrian SK (1977) Prenatal morphine alters behavioral development in the rat. Pharmacol Biochem Behav 7:285–288
Sparber SB, Shideman FE (1968) Prenatal administration of reserpine: effect upon hatching, behavior and brainstem catecholamines of the young chick. Dev Psychobiol 1:236–244
Stephenon JPB (1976) Epilepsy: a neurological complication of thalidomide embryopathy. Dev Med Child Neurol 18:189–197
Stillman R, Petersen RC (1979) The paradox of phencyclidine (PCP) abuse. Ann Intern Med 90:428–429
Strauss ME, Starr RH, Ostrea EM, Chavez CJ, Stryker JC (1976) Behavioral concomitants of prenatal addiction to narcotics. J Pediatr 89:842–846
Strauss ME, Lessen-Firestone JK, Chavez CJ, Stryker JC (1979) Children of methadone-treated women at five years of age. Protracted effects of perinatal drug dependence. Pharmacol Biochem Behav [Suppl] 11:3–6
Streissguth AP, Herman CS, Smith DW (1978) Intelligence, behavior, and dysmorphogenesis in the fetal alcohol syndrome: a report on 20 patients. J Pediatr 92:363–367
Streissguth AP, Landesman-Dwyer S, Martin JC, Smith DW (1980) Teratogenic effects of alcohol in humans and laboratory animals. Science 209:353–361
Ting R, Keller A, Berman P, Finnegan L (1974) Follow-up studies of infants born to methadone-dependent mothers [Abstr]. Pediatr Res 8:346
Vacca L, Hutchings DE (1977) Effect of maternal vitamin A excess on S-100 in neonatal rat cerebellum: a preliminary study. Dev Psychobiol 10:171–176
Warner RH, Rosett HL (1975) The effects of drinking on offspring: an historical survey of the American and British literature. J Stud Alcohol 36:1395–1420
Werboff J, Dembicki EL (1962) Toxic effects of tranquilizers administered to gravid rats. J Neuropsychiatry 4:87–91
Werboff J, Havlena J (1962) Postnatal behavioral effects of tranquilizers administered to the gravid rat. Exp Neurol 6:263–269
Werboff J, Kesner R (1963) Learning deficits of offspring after administration of tranquilizing drugs to the mothers. Nature 197:106–107
Werboff J, Gottlieb JS, Dembicki EL, Havlena J (1961 a) Postnatal effect of antidepressant drugs administered during gestation. Exp Neurol 3:542–555
Werboff J, Gottlieb JS, Havlena J, Word JJ (1961 b) Behavioral effects of prenatal drug administration in the white rat. Pediatrics 27:318–324
Wilson G, Desmond M, Verniaud W (1973) Early development of infants of heroin-addicted mothers. Am J Dis Child 126:457–462
Wilson GS, McCreary R, Kean J, Baxter JC (1979) The development of preschool children of heroin-addicted mothers: a controlled study. Pediatrics 63:135–141
Wilson JG (1973) Environment and birth defects. Academic Press, New York
Young RD (1967) Developmental psychopharmacology: a beginning. Psychol Bull 67:73–86
Zackai EH, Mellman WJ, Neiderer B, Hanson JW (1975) The fetal trimethadione syndrome. J Pediatr 87:280–284
Zagon IS, McLaughlin PJ (1977 a) The effects of different schedules of methadone treatment on rat brain development. Explor Neurol 56:538–552
Zagon IS, McLaughlin PJ (1977 b) Methadone and brain development. Experientia 33:1486
Zagon IS, McLaughlin PJ, Thompson CI (1979 a) Development of motor activity in young rats following perinatal methadone exposure. Pharmacol Biochem Behav 10:743–749
Zagon IS, McLaughlin PJ, Thompson CI (1979 b) Learning ability in adult female rats perinatally exposed to methadone. Pharmacol Biochem Behav 10:889–894
Zemp JW, Middaugh LD (1975) Some effects of prenatal exposure to d-amphetamine sulfate and phendbarbital on developmental neurochemistry and on behavior. Addict Dis 2:307–331
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hutchings, D.E. (1983). Behavioral Teratology: A New Frontier in Neurobehavioral Research. In: Johnson, E.M., Kochhar, D.M. (eds) Teratogenesis and Reproductive Toxicology. Handbook of Experimental Pharmacology, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81919-3_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-81919-3_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81921-6
Online ISBN: 978-3-642-81919-3
eBook Packages: Springer Book Archive