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Kinetics of Antibacterial Effects

  • Chapter
Inhibition of Folate Metabolism in Chemotherapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 64))

Abstract

Several bacteriologic and biochemical investigations have been done to evaluate the effectiveness and mode of action of the drug combination, Septrin, Eusaprim, and Bactrim, consisting of trimethoprim, 2,4-diamino-5-(3′,4′,5′-trimethoxybenzyl)pyrimidine (TMP) and a sulfonamide, sulfamethoxazole (SMX). Many of these studies have been concerned with the mode of action, sensitivity testing procedures, or the development of resistance (Hitchings and Burchall 1965; Bushby and Barnett 1967; Böhni 1969; Tiesler 1970). A potentiating effect of TMP on sulfonamides (or vice versa) has been stated to occur (Bushby and Hitchings 1968; Fowle 1970; Bushby 1970; Then and Angehrn 1973; Then 1977). This has been said to be the consequence of the fact that the sites of action of the inhibitors are two different steps in the same biosynthetic pathway (Hitchings and Burchall 1965). In addition, decrease in the rate of development of resistance has been claimed when the bacterial strain is initially sensitive to both antibacterials (Bushby and Barnett 1967). A review article has summarized these studies as well as the pharmacologic and clinical investigations of the antibacterial combination (Garrod 1971).

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Authors
  1. J. K. Seydel
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Burroughs Wellcome Co., 3030 Cornwallis Road, Research Triangle Park, 27709, NC, USA

    George H. Hitchings

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© 1983 Springer-Verlag Berlin Heidelberg

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Seydel, J.K. (1983). Kinetics of Antibacterial Effects. In: Hitchings, G.H. (eds) Inhibition of Folate Metabolism in Chemotherapy. Handbook of Experimental Pharmacology, vol 64. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81890-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-81890-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81892-9

  • Online ISBN: 978-3-642-81890-5

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