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Inhibition of Folate Metabolism in Chemotherapy pp 343–355Cite as

Treatment of Genital Infections with Trimethoprim, Sulfonamides, and Combinations

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 64))

Abstract

Shortly after their introduction into clinical medicine in the late 1930 s, sulfonamides were found to be effective treatment for several sexually transmitted diseases, specifically gonorrhea, chancroid, and lymphogranuloma venereum. Early studies showed that 80%–90% of gonococcal isolates were sensitive in vitro to sulfonamides, but by 1942 rapid emergence of resistance occurred and the majority of isolates from patients with uncomplicated gonorrhea were resistant to sulfonamides in vitro. Penicillin replaced sulfonamides as the preferred treatment for gonorrhea. Interestingly, by 1954 and continuing to the present, most gonococci again show in vitro sensitivity to sulfonamide. Unlike gonorrhea, chancroid, and lymphogranuloma venereum have been treated successfully with sulfonamides consistently since 1938.

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References

  • Arya OP, Pearson CH, Rao SJ, Blowers R (1970) Treatment of gonorrhea with trimethoprim-sulfamethoxazole in Uganda. Br J Vener Dis 46: 214–216

    PubMed  CAS  Google Scholar 

  • Asin J (1952) Chancroid — a report of 1,402 cases. Am J Syphilis Gonorrhea Vener Dis 36: 483–487

    CAS  Google Scholar 

  • Austin TW, Holmes KK (1975) The use of trimethoprim-sulfamethoxazole in gonococcal infections. Can Med Assoc J 112: S37–39S

    Google Scholar 

  • Austin TW, Brooks GF, Bethel M, Roberts FL, Turck M, Holmes KK (1973) Trimethoprim-sulfamethoxazole in the treatment of gonococcal urethritis: clinical and laboratory correlates. J Infect Dis 128:S 666—S 672

    Google Scholar 

  • Bowie WR, Alexander ER, Floyd JF, Holmes J, Miller Y, Holmes KK (1976) Differential response of chlamydial and ureaplasma-associated urethritis to sulphafurazole (sulfisoxazole) and aminocyclitols. Lancet 2: 1276–1278

    Article  PubMed  CAS  Google Scholar 

  • Brathwaite AR (1975) Treatment of gonorrhea in the male with trimethoprim-sulfamethox-azole using a one-or two-dose regimen. Can Med Assoc J 112:43 S-46

    Google Scholar 

  • S Bro-Jorgensen A, Jensen T (1973) Gonococcal pharyngeal infections: report of 110 cases. Br J Vener Dis 49: 491–499

    PubMed  CAS  Google Scholar 

  • Caerasques LG (1966) Chancroid treatment with sulfamethoxytyridazine. Dermatologica [Venezolana] 5: 86–87

    Google Scholar 

  • Carroll BRT, Nicol CS (1970) Trimethoprim-sulfamethoxazole in NGU and gonorrhea. Br J Vener Dis 46: 31–33

    PubMed  CAS  Google Scholar 

  • Csonka TW, Knight GJ (1967) Therapeutic trial of trimethoprim as a potentiator of sulfonamides in gonorrhea. Br J Vener Dis 43: 161–165

    PubMed  CAS  Google Scholar 

  • Danielsson D, Wikström KJ (1975) Diagnostic aspects of gonococcal and nongonococcal urethritis. Results of treatment with trimethoprim-sulfamethoxazole. In: Danielsson D, Juhlin L, Mârdh PA (eds) Genital infections and their complications. Almqvist and Viksel, Stockholm, pp 299–307

    Google Scholar 

  • Duncan WC, Knox JM, Jackson TH (1975) Trimethoprim-sulfamethoxazole in the treatment of gonorrhea. South Med J 68: 1147–1151

    Article  PubMed  CAS  Google Scholar 

  • Elliott WC, Reynolds G, Thornsberry C et al. (1977) Treatment of gonorrhea with trimethoprim-sulfamethoxazole. J Infect Dis 135: 939–943

    Article  PubMed  CAS  Google Scholar 

  • Evans AJ, Churcher TM, Human RP (1972) Trimethoprim-sulfamethoxazole in the treatment of gonorrhea. Br J Vener Dis 48: 179–181

    PubMed  CAS  Google Scholar 

  • Hammond GW, Lian CJ, Wilt JC, Ronald AR (1978) Antimicrobial susceptibility of Hemophilus ducreyi. Antimicrob Agents Chemother 13: 608–612

    PubMed  CAS  Google Scholar 

  • Kerber RE, Row CE, Gilbert KR (1969) Treatment of chancroid. Arch Dermatol 100: 604–607

    Article  PubMed  CAS  Google Scholar 

  • Koteen H (1945) Lymphogranuloma venereum. Medicine 24: 1–69

    Article  Google Scholar 

  • Kristensen JK, From E (1975) Trimethoprim-sulfamethoxazole in gonorrhea: a comparison with pivampicillin combined with probenecid. Br J Vener Dis 51: 31–33

    PubMed  CAS  Google Scholar 

  • Lawrence A, Phillips I, Nicol C (1973) Various regimens of trimethoprim-sulfamethoxazole used in the treatment of gonorrhea. J Infect Dis 128:S 673—S 678

    Google Scholar 

  • Lee VS (1975) Therapie-Erfahrung mit Trimethoprim-Sulfamethoxazole bei der post-gonorrhoischen Urethritis. Z Allg Med 27: 1207–1209

    Google Scholar 

  • Levaditi C (1938) Chemotherapie de la lymphogranulomatose inguinale experimentale. C R Soc Biol (Paris) 128: 138–142

    CAS  Google Scholar 

  • MacCallum FO, Findlay GM (1938) Chemotherapeutic experiments on the virus of lymphogranuloma inguinale in the mouse. Lancet 2: 136–138

    Article  Google Scholar 

  • Mahoney JDH, McCann JS, Harris JRW (1973) Comparison of trimethoprim-sulfameth- oxazole and penicillin in the treatment of gonorrhea. Br J Vener Dis 49: 517–520

    Google Scholar 

  • Mahoney JDH, McCann JS, Harris JRW, Howe JG, Dougan HJ (1974) Oxytetracycline compared with single-dose therapy with sulfamethopyrazine/streptomycin sulfate in NGU in males. Br J Clin Pract 28: 179–181

    Google Scholar 

  • Marmar JL (1972) The management of resistant chancroid in Vietnam. J Urol 107: 807–808

    PubMed  CAS  Google Scholar 

  • Meheus AZ, Ngamige E, Freyens P (1974) Treatment of gonorrhea with trimethoprim-sul-famethoxazole and probenecid plus procaine penicillin in Rwanda. Br J Vener Dis50: 447–449

    Google Scholar 

  • Nelson M, Bresher JT, Duncan WC, Eakins W, Knox JM (1975) Comparison of trimethoprim-sulfamethoxazole with penicillin and tetracycline in the treatment of uncomplicated gonorrhea in women. Can Med Assoc J 112:43 S-46S

    Google Scholar 

  • Paavonen J, Kousa M, Saikku T, Vartiainen E, Kanerva L, Lassus A (1980) Treatment of nongonococcal urethritis with trimethoprim-sulfadiazine and with placebo: a double-blind, partner-controlled study. Br J Vener Dis 56: 101–104

    PubMed  CAS  Google Scholar 

  • Rahim G (1975) Single-dose treatment of gonorrhea with cotrimoxazole — a report of 1,023 cases. Br J Vener Dis 51: 179–182

    PubMed  CAS  Google Scholar 

  • Rodin T, Seth AD (1972) Treatment of gonorrhea with cotrimethoxazole, procaine penicil- lin alone, and procaine penicillin plus probenecid. Br J Vener Dis 48: 517–521

    PubMed  CAS  Google Scholar 

  • Sattler FR, Ruskin J (1978) Therapy of gonorrhea: comparison of trimethoprim-sulfameth-oxazole and ampicillin. JAMA 240: 2267–2270

    Article  PubMed  CAS  Google Scholar 

  • Stamps TJ (1974) Experience with doxycycline in the treatment of chancroid. J Trop Med Hyg 77:55-60

    Google Scholar 

  • Svindland HB (1973) Treatment of gonorrhea with trimethoprim-sulfamethoxazole: Lack of effect on concomitant syphilis. Br J Vener Dis 49: 50–53

    PubMed  CAS  Google Scholar 

  • Ullman S, Niordson AM, Zachariae H (1971) Trimethoprim-sulfamethoxazole in gonorrhea. Acta Derm Venereol (Stockh) 51: 394–395

    CAS  Google Scholar 

  • Watko LP, Kilpatrick ME, Hooper RR, Harrison WO (1977) Evaluation of cotrimoxazole in the treatment of penicillin-resistant gonorrhea. Program Abstr 17th Intersci Conf Antimicrob Agents Chemother, Abstr 262. American Society for Microbiology, Washington, DC

    Google Scholar 

  • Wigfield AS, Selkon JB, Rich GE (1973) Single-session treatment of uncomplicated gonor-rhea in men using penicillin combined with cotrimoxazole. Br J Vener Dis 49: 277–290

    PubMed  CAS  Google Scholar 

  • Wilcox RR (1963) The treatment of chancroid. Br J Clin Pract 17: 455–460

    Google Scholar 

  • Wormser GP (1978) Trimethoprim-sulfamethoxazole in the treatment of genital infections.NY State J Med 78: 2058–2067

    CAS  Google Scholar 

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Authors
  1. W. E. Stamm
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Burroughs Wellcome Co., 3030 Cornwallis Road, Research Triangle Park, 27709, NC, USA

    George H. Hitchings

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© 1983 Springer-Verlag Berlin Heidelberg

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Stamm, W.E. (1983). Treatment of Genital Infections with Trimethoprim, Sulfonamides, and Combinations. In: Hitchings, G.H. (eds) Inhibition of Folate Metabolism in Chemotherapy. Handbook of Experimental Pharmacology, vol 64. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81890-5_17

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  • DOI: https://doi.org/10.1007/978-3-642-81890-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81892-9

  • Online ISBN: 978-3-642-81890-5

  • eBook Packages: Springer Book Archive

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