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Trimethoprim Alone: Clinical Uses

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Inhibition of Folate Metabolism in Chemotherapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 64))

Abstract

Trimethoprim (TMP) is an effective and potent antibacterial agent. Although academics and practitioners alike have been intrigued by the consistent enhancement of TMP’s activity by sulfamethoxazole and have more recently been fascinated by its synergism with other sulfonamides as well as agents as disparate as polymyxin and rifampin, it would be unfortunate if this intellectual attraction were to prevent a critical examination of the potential use of TMP alone in certain infections. In this chapter, the accumulated clinical data on the use of TMP as a single entity will be reviewed so that the comparative safety and efficacy of this drug may be defined. We will also analyze those clinical situations in which its synergistic activity with sulfamethoxazole is required to cure the infection and those in which it is not. In addition, by examination of available in vitro, epidemiologic, and human experimental data, the risk and clinical relevance of the potential emergence of TMP-resistant organisms may be determined.

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  1. D. W. Barry
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  2. K. H. Pattishall
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  1. The Wellcome Research Laboratories, Burroughs Wellcome Co., 3030 Cornwallis Road, Research Triangle Park, 27709, NC, USA

    George H. Hitchings

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Barry, D.W., Pattishall, K.H. (1983). Trimethoprim Alone: Clinical Uses. In: Hitchings, G.H. (eds) Inhibition of Folate Metabolism in Chemotherapy. Handbook of Experimental Pharmacology, vol 64. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81890-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-81890-5_13

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