A Medical Perspective of Women Aged 35–45

  • W. H. Utian
Conference paper

Abstract

The process of aging, a continuum from conception until death, is demarcated in the female by several specific milestones, including menarche and menopause. The pertinent question addressed by this communication is whether the later reproductive years in the human female represent a period of real medical risk. The differentiation of specific sex-related disorders from the concurrent aging process and associated psychosocio-cultural factors represents a difficult challenge.

Keywords

Fatigue Obesity Migration Depression Estrogen 

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References

  1. Baird DT, Horton R, Longcope C et al. (1969) Steroid dynamics under steadystate conditions. Recent Prog Horm Res 25: 611PubMedGoogle Scholar
  2. Ben-David M, L’Hermite M (1976) Prolactin and menopause. In: van Keep (ed) Consenus on menopause research. MTP press, Lancaster, p 19Google Scholar
  3. Bloch E (1952) Acta Anat 14: 108CrossRefGoogle Scholar
  4. Bloch E (1953) A quantitative morphological investigation of the follicular system in newborn female infants. Acta Anat 17: 201CrossRefGoogle Scholar
  5. Costoff A (1974) An ultrastructural study of ovarian changes in the menopause. In: Greenblatt RB, Mahesh VB, McDonough PG (eds) The menopausal syndrome. Medcom, New York, p 12Google Scholar
  6. De Jong FH, Sharpe RM (1976) Evidence of inhibin like activity in bovine follicular fluid. Nature 263: 71PubMedCrossRefGoogle Scholar
  7. England PK, Skinner LG, Cottrell KM, Sellwood RA (1974) Serum oestradiol-17B in normal women. Br J Cancer 29: 462PubMedCrossRefGoogle Scholar
  8. Finn CA (1976) Investigations into reproductive ageing in experimental animals. In: Beard RD (ed) The menopause. MTP Press, LancasterGoogle Scholar
  9. Hodgen GD, Goodman AL, O’Connor A, Johnson DK (1977) Menopause in rhesus monkeys. Model for study of disorders in human climacteric. Am J Obstet Gynecol 127: 581PubMedGoogle Scholar
  10. Jones EC (1975) The post-reproductive phase in mammals. In: Estrogens in the postmenopause. Front Horm Res 3: 1PubMedGoogle Scholar
  11. Jones EC, Krohn PL (1961) The relationship between age, numbers of occytes and fertility in virgin and multiparous mice. J Endocrinol 21: 469PubMedCrossRefGoogle Scholar
  12. Kirschner MA, Jacobs JF (1971) Combined ovarian and adrenal vein catheterization to determine the site(s) of androgen overproduction in Hirsute women. J Clin Endocrinol Metab 33: 199PubMedCrossRefGoogle Scholar
  13. Mandl AM, Shelton M (1959) A quantitative study of oocytes in young and old multiparous rats. J Endocrinol 18: 44Google Scholar
  14. Mandl AM, Zuckerman S (1951) The relation of age to numbers of oocytes. J Endocrinol 7: 190PubMedCrossRefGoogle Scholar
  15. Mishell DR, Nakamura RM, Grosignani PG et al. (1971) Serum Gonadotropin and steroid patterns d during the normal menstrual cycle. Am J Obstet Gynecol 111: 60PubMedGoogle Scholar
  16. Moore KL (1973) The developing human — clinically orientated embryology. Saunders, PhiladelphiaGoogle Scholar
  17. National Center for Health Statistics (1965) Vital and Health Statistics. Changes in mortality trends: England and Wales 1931–1961. Series 3, Number 3, November. DHEW, WashingtonGoogle Scholar
  18. National Center for Health Statistics (1976) Blood pressure of persons 6–74 years of age in the United States. DHEW Publication No. (HRA) 77–1250, WashingtonGoogle Scholar
  19. Papanicolaou AD, Loraine JA, Dove GA, Loudon NB (1969) Hormone excretion patterns in peri-menopausal women. J Obstet Gynaecol Br Commonw 76: 308PubMedCrossRefGoogle Scholar
  20. Pincus G, Romanoff LP, Carlo J (1954) The excretion of urinary steroids by men and women of various ages. J. Gerontol 9: 113PubMedGoogle Scholar
  21. Reid DE, Ryan KJ, Benirshke K (1972) Principles and management of human reproduction. Saunders, PhiladelphiaGoogle Scholar
  22. Reyes FI, Winter SK, Faiman C (1977) Pituitary-ovarian relationships preceding the menopause. Am J Obstet Gynecol 129: 557PubMedGoogle Scholar
  23. Rice BF, SAvard K (1966) Steroid hormone formation in the ovary. J Clin Endocrinol 26: 593CrossRefGoogle Scholar
  24. Sherman BM, Korenman SG (1975) Hormonal characteristics of the human menstrual cycle throughout reproductive life. J Clin Invest 55: 699PubMedCrossRefGoogle Scholar
  25. Sherman BM, West JH, Korenman SG (1976) The menopausal transition: Analysis of LH, FSH, estradiol and progesterone concentrations during menstrual cycles of older women. J Clin Endocrinol Metab 42: 247CrossRefGoogle Scholar
  26. Smith OW, Ryan KJ (1962) Estrogen in the human ovary. Am J Obstet Gynecol 84: 141PubMedGoogle Scholar
  27. Treloar AE, Bynton RE, Benn BG, Brown BW (1967) Variation for the human menstrual cycle through reproductive life. Int J Fertil 12: 77PubMedGoogle Scholar
  28. U.S. Department of Health, Education and Welfare (1974) National Vital Statistics System: Mortality trends for leading causes of death. DHEW Publication No. (HRA) 74–1853, Rockville, MarylandGoogle Scholar
  29. U.S. Department of Health, Education and Welfare (1978a) Health, United States 1976–1977. DHEW Publication No. (HRA) 77–1232, MarylandGoogle Scholar
  30. U.S. Department of Health, Education and Welfare (1978b) The national ambulatory medical care survey: 1975 summary. DHEW Publication No. (PHS) 78–1784, Hyattsville, MarylandGoogle Scholar
  31. Utian WH (1980) Menopause in modern perspective. Appleton, New YorkGoogle Scholar
  32. Van de Wiele, Bogumil J, Dyrenfurth I et al. (1970) Mechanisms regulating the menstrual cycle in women. Recent Prog Horm Res 26: 63Google Scholar
  33. Van Keep, Lauritzen (1975) Front. Horm. Res. 3: 5Google Scholar
  34. van Look PFA, Lothian H, Hunter WM, Michie EA, Baird ST (1977) Hypothalamic-pituitary-ovarian function in perimenopausal women. Clin Endocrinol 7: 13CrossRefGoogle Scholar
  35. Vekemans M, Robyn C (1975) Influence of age on serum prolactin in women and men. Br Med J 4: 738PubMedCrossRefGoogle Scholar
  36. Wagenen G van (1972) Vital statistics from a breeding colony. J Med Primatol 1: 3Google Scholar
  37. Wide L, Nillius SJ, Gemzell C, Roos P (1973) Radio immunoabsorbent assay of FSH and LH in serum and urine from men and women. Acta Endocrinol [Suppl] 174: 41Google Scholar
  38. Witschi E (1948) Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. Contrib Embryol Carnegie Inst 32: 67Google Scholar
  39. Yen SSC, Ehara Y, Siler TM (1974) Augmentation of prolactin secretion by estrogen in hypogonada women. J Clin Invest 53: 652PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1982

Authors and Affiliations

  • W. H. Utian

There are no affiliations available

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