Pathology of Hirschsprung’s Disease and Ischaemic Colitis

  • B. Wiebecke
Conference paper


Megacolon is a typical phenomenon in Hirschsprung’s disease and, as is well known, it is the consequence of aganglionosis in the narrow distal segment. This aganglionosis results from a failure of immigration into the bowel wall of neuroblasts from the vagal neural crest (Yntema and Hammond 1954), which normally progress from the caecum to the distal colon between the 8th and 12th weeks of embryonic life. Impaired embryo-genesis during this period therefore results in aganglionosis and absence of the intramural and submucous plexus of different extent according to the onset of the impairment, the supra-anal rectum nearly always being involved.


Circular Muscle Ischaemic Colitis Narrow Segment Ischaemic Lesion Rectal Suction Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Balslev I, Jensen H-E, Norgaard F, Poll P (1970) Ischemic colitis. Acta Chir Scand 136: 235PubMedGoogle Scholar
  2. Bodian M, Carter CO (1963) A family study of Hirschsprung’s disease. Ann Hum Genet 26: 261CrossRefGoogle Scholar
  3. Freeman NV (1971) Long segment Hirschsprung’s disease. Proc R Soc Med 64: 378PubMedGoogle Scholar
  4. Huber FB (1980) Ischämische Entero-Kolopathien. Aktuel Probl Chir Orthop 16Google Scholar
  5. Marston A, Pheils A, Thomas MT, Morson BC (1966) Ischaemic colitis. Gut 7: 1PubMedCrossRefGoogle Scholar
  6. Meier-Ruge W (1974) Hirschsprung’s disease: Its aetiology, pathogenesis and differential diagnosis.Google Scholar
  7. Norris HT (1977) Ischemic bowel disease. Its spectrum, In: Gadley JH (ed.) pp 15–30 The gastrointestinal tract. Williams & Wilkins, Baltimore International Academy of Pathology Monographs, vol 21Google Scholar
  8. Rehbein F, Halsband H, Hofmann S (1969) Hirschsprungsche Krankheit mit langem, engem Segment. Dtsch Med Wochenschr 94: 708PubMedCrossRefGoogle Scholar
  9. Saegesser F, Roenspies U, Robinson JWL (1979) Ischemic disease of the large intestine. Pathobiol Ann 9: 303Google Scholar
  10. Walker AW, Kempson RL, Ternberg JL (1966) Aganglionosis of the small intestine. Surgery 60: 449PubMedGoogle Scholar
  11. Yntema CL, Hammond WS (1954) Origin of intrinsic ganglia of trunk viscera from vagal neural crest in chick embryo. J Comp Neurol 101: 515PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • B. Wiebecke

There are no affiliations available

Personalised recommendations