The Plasma Cholesterol: Cholesterol-Ester Cycle

  • S. Eisenberg
  • B. Perret
Conference paper


Three years ago, at the V International Symposium on Atherosclerosis (l), we have presented evidence that both LDL and HDL are metabolic products of the core and surface domains of triglyceride-rich lipoproteins. The data can be summarized as follows: Triglyceride-rich lipoproteins (chylomicrons and VLDL) are primary secretory products of intestinal and hepatic cells. In the plasma, the two lipoproteins interact with lipoprotein lipases at luminal surfaces of endothelial cells and deliver triglyceride-fatty acids to tissues. The reaction leaves behind a triglyceride-depleted lipoprotein that contains non-hydrolyzable core lipids (cholesterol esters) and residual triglycerides. As well, the post-lipolysis particles remain with excess of surface constituents, phospholipids, free cholesterol and apoproteins. Our experiments indicated that the metabolism of non-triglyceride molecules in chylomicrons and VLDL is best described along two pathways: a core pathway, and a surface pathway (2, 3). Along the core pathway, the lipoprotein cholesterol ester and residual triglyceride molecules together with apo B and sufficient quantities of phospholipids and free cholesterol form remnant particles or LDL (4). Along the surface pathway, HDL precursors are formed (4, 5). These precursors are converted to spherical HDL by the activity of the LCAT system and accumulation of cholesterol ester molecules.


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© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • S. Eisenberg
  • B. Perret

There are no affiliations available

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