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Determination of Plasma Apolipoprotein Profiles

  • Conference paper
Atherosclerosis VI

Abstract

Rapid advances in the chemistry and metabolism of plasma apolipoproteins have already produced a considerable impact on the existing conceptual views about the plasma lipoprotein system. They have shifted the attention from lipid to protein constituents and emphasized the significance of apolipoproteins as the most probable determinants of the structural stability and functional specificity of lipoprotein particles (1, 2). While the discovery of new apolipoproteins and their wide distribution throughout the density spectrum have revealed a new dimension in the complexity of plasma lipoproteins, the recognition of apolipoproteins as unique constituents and specific markers of a great variety of lipoprotein particles has provided a convenient and simple means for their identification and classification (1–3). According to this view, plasma lipoprotein system consists of a mixture of lipoprotein families which are differentiated and characterized on the basis of their constituent apolipoproteins. Lipoprotein families which contain a single apolipoprotein are referred to as simple or primary lipoprotein families; these lipoprotein families represent the simplest lipoprotein forms of the system. Lipoprotein families which contain two or more apolipoproteins are called complex or secondary lipoprotein families (2, 3). It has now become possible by use of specific immunological procedures to identify individual lipoprotein families and to monitor their formation, interactions and degradation irrespective of their size, hydrated density or lipid composition.

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Authors
  1. P. Alaupovic
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Editors and Affiliations

  1. Medizinische Klinik, Bergheimer Str. 58, 6900, Heidelberg, Germany

    F. Gotthard Schettler , Gert Middelhoff , Andreas J. R. Habenicht  & Klara R. Jurutka , ,  & 

  2. Department of Medicine, Baylor College of Medicine, 77030, Houston, Texas, USA

    Antonio M. Gotto Jr. M.D., Ph.D.

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© 1983 Springer-Verlag Berlin Heidelberg

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Alaupovic, P. (1983). Determination of Plasma Apolipoprotein Profiles. In: Schettler, F.G., Gotto, A.M., Middelhoff, G., Habenicht, A.J.R., Jurutka, K.R. (eds) Atherosclerosis VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81817-2_93

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  • DOI: https://doi.org/10.1007/978-3-642-81817-2_93

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81819-6

  • Online ISBN: 978-3-642-81817-2

  • eBook Packages: Springer Book Archive

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