Altered Growth Stimulation and LDL Degradation in Human Arterial Smooth Muscle Cells (ASMC) and Fibroblasts (F) by Low Molecular Weight Serum Factors from Typre II Diabetics

  • T. Koschinsky
  • C. Bünting
  • F. A. Gries
Conference paper


Effects of a prolonged exposure of arterial wall cells to an abnormal metabolic environment have been suspected as angiopathic factors in different metabolic diseases including diabetes. Altered growth and lipoprotein metabolism have been implicated but the nature of the pathogenic metabolic factors in non insulin dependent diabetics (NIDDM) is still unknown.


Serum Factor Arterial Smooth Muscle Cell Serum Fraction Altered Growth Growth Stimulate Activity 
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  1. 1).
    Koschinsky T, Bunting C, Schwippert B, Gries FA (1980) Increased growth stimulation of fibroblasts from diabetics by diabetic serum factors of low molecular weight. Atherosclerosis 37: 311–317PubMedCrossRefGoogle Scholar
  2. 2).
    Koschinsky T, Bunting C, Schwippert B, Gries FA (1982) Studies on inherited and acquired metabolic disorders in cultured arterial smooth muscle cells and fibroblasts. Int. J. Obes. (in press)Google Scholar
  3. 3).
    Koschinsky T, Bunting C, Schwippert B, Gries FA (1981) Regulation of diabetic serum growth factors for human vascular cells by the metabolic control of diabetes mellitus. Atherosclerosis 39: 313–319PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • T. Koschinsky
  • C. Bünting
  • F. A. Gries

There are no affiliations available

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