Role of Connective Tissue in the Arterio-Atherosclerotic Process. Interest of a Cell-Matrix Directed Pharmacology

  • L. Robert
  • W. Hornebeck
  • A. M. Robert
Conference paper

Abstract

Vascular wall of all sizes from capillaries to the large arterial trunks contain cells and intercellular matrix variable in quantity (cell/matrix ratio), and also in quality (nature and relative amount of matrix macromolecules). Capillaries contain basement membranes elaborated by endothelial cells and perhaps pericytes. Basement membranes are known to be composed of several matrix macromolecules, such as collagen type IV, laminin, fibronectin, heparan-sulphate proteoglycans and some other less well characterised glycoproteins (1, 2, 3). The large vessel walls such as the aorta contain several differentiated cell types such as the endothelial cells, smooth muscle cells, fibroblasts and probably also migrating cells such as monocytes-macrophages. Such vessels contain also large amounts of intercellular matrix macromolecules and the cell/matrix ratio is often much in favor of the intercellular matrix. Several laboratories invested a great effort in the isolation and characterisation of the intercellular matrix components of vascular wall. It is beyond the scope of this presentation to review this rapidly growing field. Instead we shall describe shortly some of those experiments which enlighten the intricate interrelationship between cells and the intercellular matrix elements of the vascular wall.

Keywords

Cholesterol Permeability Oligomer Prostaglandin Calcitonin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • L. Robert
  • W. Hornebeck
  • A. M. Robert

There are no affiliations available

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