It is well-recognized that the level of serum cholesterol can be lowered significantly in human subjects by substituting polyunsaturated fat for saturated fat in their diet (1–3). Since a high level of serum cholesterol is considered to be a major risk factor for cardiovascular disease, individuals with elevated serum cholesterol are often advised to decrease their intake of saturated fat and to eat more polyunsaturated fat. A change in this direction was also recommended for the population of the United States as a whole in the Dietary Guidelines prepared by a Select Committee of the United States Senate. These Guidelines suggested that dietary fat intake be reduced to 30% of calories and that the proportions be altered so as to provide approximately equal amounts of polyunsaturated, monounsaturated, and saturated fat (4).
KeywordsBile Acid Serum Cholesterol Dietary Cholesterol Colon Carcinogenesis Mammary Carcinogenesis
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