It is well-recognized that the level of serum cholesterol can be lowered significantly in human subjects by substituting polyunsaturated fat for saturated fat in their diet (1–3). Since a high level of serum cholesterol is considered to be a major risk factor for cardiovascular disease, individuals with elevated serum cholesterol are often advised to decrease their intake of saturated fat and to eat more polyunsaturated fat. A change in this direction was also recommended for the population of the United States as a whole in the Dietary Guidelines prepared by a Select Committee of the United States Senate. These Guidelines suggested that dietary fat intake be reduced to 30% of calories and that the proportions be altered so as to provide approximately equal amounts of polyunsaturated, monounsaturated, and saturated fat (4).
KeywordsCholesterol Anthracene Choles Ster Macrolide
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