Chairman’s Introduction to Workshop on Regression

  • R. W. Wissler


Regression of advanced atherosclerosis has now been well documented in experimental animals and humans (1 – 4). Regression, like the pathological state to which it is applied, is a multifactorial process which seems to take place at varying rates depending on the methods of measurement and/or the plaque components being evaluated (5). The most prominent beneficial aspects of regression of the established atherosclerotic plaque which have been well documented now in the “best” (most human-like) animal models* utilized to study this process are as follows:
  1. 1.

    Smaller overall size of the plaque.

  2. 2.

    Necrotic center decreases or disappears.

  3. 3.

    Intracellular and non fiber-bound extracellular lipid are diminished greatly.

  4. 4.

    Cell proliferation is greatly retarded and number of cells in lesion decrease.

  5. 5.

    Endothelial injury heals.

  6. 6.

    Collagen and elastin become more condensed and decrease relative to anatomical units.

  7. 7.

    Calcium sometimes becomes less prominent.



Plaque Component Muscular Artery Advanced Atherosclerosis Aortic Atherosclerosis Atheromatous Lesion 
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© Springer-Verlag Berlin Heidelberg 1983

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  • R. W. Wissler

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