Measurement of Monotypism in Atherosclerosis
In 1973, Dr. Earl Benditt and his associate reported extremely interesting and provocative findings in regard to the origin of atherosclerotic lesions (1). These investigators have been studying atherosclerotic lesions in autopsy specimens from black women who were heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD), using techniques that had been developed for investigating the origin of neoplasms. They found many advanced atherosclerotic lesions are monotypic or at least have monotypic foci. With these findings they concluded that each atherosclerotic lesion probably arose from a single, genetically transformed cell and thus constituted a single clone (monoclonal origin). This had been shown to be the case for leiomyomas and for certain other neoplasms. The obvious inference to be drawn was that atherosclerotic lesions were in fact neoplasms. Since then many observations have been made on this phenomenon in a number of laboratories including ours. We have studied similar atherosclerotic lesions with monotypic foci and have concluded, from similar data to those reported by Dr. Benditt and his associate that the observed monotypism has causes other than monoclonism and hence it does not indicate monoclonal origin of the lesions (2).
KeywordsBlack Woman Atherosclerotic Lesion Skin Fibroblast Culture Phenotypic Shift Rotic Lesion
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