Abstract
The development of hypertensive rat models for atherogenesis and myocardial lesions by a selective inbreeding from spontaneously hypertensive rats (SHR) (1) has added new experimental approach to the pathogenesis, regression and prevention of these very common cardiovascular diseases in man. In this paper the development of various rat models for cardiovascular diseases is reviewed with a special reference to basic vascular lesions noted in hypertension, and then our models for atherogenesis and thrombogenesis, and also a new model for myocardial infarction which is caused by the combination of both thrombosis and atherosclerosis are reported together with our recent findings on the regression of atherosclerosis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Okamoto K, Aoki K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27: 282–293
Yamori Y, Nagaoka A, Okamoto K (1974) Importance of genetic factors in hypertensive cerebrovascular lesions: An evidence obtained by successive selective breeding of stroke-prone and resistant SHR. Jpn Circ J 38: 1095–1100
Yamori Y, Ohta K, Horie R, Ohtaka M, Nara Y, Ooshima A (1979) A new model for cerebral thrombosis and its pathogenesis. Jpn Heart J 20 (Suppl 1): 343–345
Yamori Y (1977) Selection of arteriolipidosis-prone rats (ALR). Jpn Heart J 18: 602–603
Yamori Y, Kihara M, Nara Y, Horie R (1982) Myocardial-ischemic rats (MIR), coronary vascular alteration induced by a lipid-rich diet. Atherosclerosis 42: 15–20
Yamori Y, Horie R, Akiguchi I, Nara Y, Ohtaka M, Fukase M (1977) Pathogenic mechanisms and prevention of stroke in stroke-prone SHR. In: De Jong W, Provoost AP, Shapiro APA (eds) Progress in Brain Research, Elsevier, Amsterdam, p 219–234
Yamori Y (1976) Neural and non-neural mechanisms in spontaneous hypertension. Clin Sci Mol Med 51: 431s-434s
Yamori Y, Igawa T, Kanbe T, Kihara M, Nara Y, Horie R (1981) Mechanisms of structural vascular changes in genetic hypertension: Analyses on cultured vascular smooth muscle cells from spontaneously hypertensive rats. Clin Sci 61 (Suppl 7): 121s–123s
Yamori Y, Iritani N, Nara Y, Fukuda E, Kitamura Y (1979) Cholesterol metabolism of arteriolipidosis-prone rats (ALR). Jpn Heart J 20 (Suppl 1): 349–351
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Yamori, Y., Horie, R., Nara, Y., Kihara, M., Wang, H., Ikeda, K. (1983). Hypertensive Rat Models of Atherosclerosis. In: Schettler, F.G., Gotto, A.M., Middelhoff, G., Habenicht, A.J.R., Jurutka, K.R. (eds) Atherosclerosis VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81817-2_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-81817-2_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81819-6
Online ISBN: 978-3-642-81817-2
eBook Packages: Springer Book Archive