Hypertensive Rat Models of Atherosclerosis

  • Y. Yamori
  • R. Horie
  • Y. Nara
  • M. Kihara
  • H. Wang
  • K. Ikeda
Conference paper


The development of hypertensive rat models for atherogenesis and myocardial lesions by a selective inbreeding from spontaneously hypertensive rats (SHR) (1) has added new experimental approach to the pathogenesis, regression and prevention of these very common cardiovascular diseases in man. In this paper the development of various rat models for cardiovascular diseases is reviewed with a special reference to basic vascular lesions noted in hypertension, and then our models for atherogenesis and thrombogenesis, and also a new model for myocardial infarction which is caused by the combination of both thrombosis and atherosclerosis are reported together with our recent findings on the regression of atherosclerosis.


Vascular Smooth Muscle Cell Atherogenic Index Myocardial Lesion Normal Protein Diet Prolyl Hydroxylase Activity 
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  1. 1.
    Okamoto K, Aoki K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27: 282–293PubMedCrossRefGoogle Scholar
  2. 2.
    Yamori Y, Nagaoka A, Okamoto K (1974) Importance of genetic factors in hypertensive cerebrovascular lesions: An evidence obtained by successive selective breeding of stroke-prone and resistant SHR. Jpn Circ J 38: 1095–1100PubMedCrossRefGoogle Scholar
  3. 3.
    Yamori Y, Ohta K, Horie R, Ohtaka M, Nara Y, Ooshima A (1979) A new model for cerebral thrombosis and its pathogenesis. Jpn Heart J 20 (Suppl 1): 343–345Google Scholar
  4. 4.
    Yamori Y (1977) Selection of arteriolipidosis-prone rats (ALR). Jpn Heart J 18: 602–603PubMedCrossRefGoogle Scholar
  5. 5.
    Yamori Y, Kihara M, Nara Y, Horie R (1982) Myocardial-ischemic rats (MIR), coronary vascular alteration induced by a lipid-rich diet. Atherosclerosis 42: 15–20PubMedCrossRefGoogle Scholar
  6. 6.
    Yamori Y, Horie R, Akiguchi I, Nara Y, Ohtaka M, Fukase M (1977) Pathogenic mechanisms and prevention of stroke in stroke-prone SHR. In: De Jong W, Provoost AP, Shapiro APA (eds) Progress in Brain Research, Elsevier, Amsterdam, p 219–234Google Scholar
  7. 7.
    Yamori Y (1976) Neural and non-neural mechanisms in spontaneous hypertension. Clin Sci Mol Med 51: 431s-434sGoogle Scholar
  8. 8.
    Yamori Y, Igawa T, Kanbe T, Kihara M, Nara Y, Horie R (1981) Mechanisms of structural vascular changes in genetic hypertension: Analyses on cultured vascular smooth muscle cells from spontaneously hypertensive rats. Clin Sci 61 (Suppl 7): 121s–123sPubMedGoogle Scholar
  9. 9.
    Yamori Y, Iritani N, Nara Y, Fukuda E, Kitamura Y (1979) Cholesterol metabolism of arteriolipidosis-prone rats (ALR). Jpn Heart J 20 (Suppl 1): 349–351Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Y. Yamori
  • R. Horie
  • Y. Nara
  • M. Kihara
  • H. Wang
  • K. Ikeda

There are no affiliations available

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