Abstract
There is increasing evidence that platelet-arterial wall interaction is an important step in the genesis of arteriosclerotic lesions (1). The genesis of these lesions may involve the following factors (2): (a) continued endothelial injury; (b) adherence and aggregation of platelets to damaged endothelial cells or to exposed subendothelial tissue; (c) local release of platelet constituents, including a mitogenic protein (platelet-derived growth factor) that stimulates growth of cultured smooth muscle cells, and passage of such platelet constituents into the underlying arterial wall; (d) migration of smooth muscle cells through the internal elastic lamina into the intima and platelet-mediated intimal proliferation of smooth muscle cells; (e) formation of a connective tissue matrix by the smooth muscle cells through synthesis and secretion of collagen, elastic fiber proteins, and glycosaminoglycans; and (f) accumulation of intracellular and extracellular lipids.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis. N Engl J Med 295:369–377; 420–425
Fuster V (1981) Role of platelets in the development of atherosclerotic disease and possible interference with platelet inhibitor drugs. Scand J Haematol 27(Suppl. 38):1
Bowie EJW, Owen CA Jr, Zollman PE, Thompson JH Jr, Fass DN (1973) Tests of hemostasis in swine: normal values and values in pigs with von Willebrand’s disease. Am J Vet Res 34:1405–1407
Mannucci PM, Pareti FI, Holmberg L, Nilsson IM, Ruggeri ZM (1976) Studies on the prolonged bleeding time in von Willebrand’s disease. J Lab Clin Med 88:662–671
Fass DN, Brockway WJ, Owen CA Jr, Bowie EJW (1976) Factor VIII (Willebrand) antigen and ristocetin-Willebrand factor in pigs with von Willebrand’s disease. Thromb Res 8:319–327
French JE, Jennings MA, Florey HW (1965) Morphological studies on atherosclerosis in swine. Ann NY Acad Sci 127:780–799
Getty R (1965) The gross and microscopic occurrence and distribution of spontaneous atherosclerosis in the arteries of swine. In Comparative Atherosclerosis: The Morphology of Spontaneous and Induced Atherosclerotic Lesions in Animals and Its Relation to Human Disease. J. C. Roberts, Jr., and R. Straus, editors. Harper & Row Publishers, Inc., New York, 11–20
Fuster V, Bowie EJW, Lewis JC, Fass DN, Owen CA Jr (1978) Resistance to arteriosclerosis in pigs with von Willebrand’s disease. Spontaneous and high cholesterol diet-induced arteriosclerosis. J Clin Invest 61:722–730
Fuster V, Fass DN, Kaye MP, Josa M, Zinsmeister AR, Bowie EJW (in press) Arteriosclerosis in normal and von Willebrand pigs: Long-term prospective study and aortic transplantatibn study. Circ Res
Booyse FM, Quarfoot AJ, Bell S, Fass DN, Lewis JC, Mann KG, Bowie EJW (1977) Cultured aortic endothelial cells from pig with von Willebrand’s disease: in vitro model for studying the molecular defect(s) of the disease. Proc Nat’l Acad Sci USA 74:5702–5706
Fuster V, Bowie EJW, Josa M, Kaye MP, Fass DN (1979) Atherosclerosis in normal and von Willebrand pigs: cross-aortic transplantation study (abstr) Thromb and Haemost 42(1):425
Fuster V, Dewanjee MK, Kaye MP, Fass DN, Bowie EJW (1980) Evaluation of platelet deposition following selective endothelial injury of the carotid artery in normal and von Willebrand pigs (abstr) Circulation 62(Suppl. 3):98
Griggs TR, Reddick RL, Sultzer D, Brinkhous KM (1981) Susceptibility to atherosclerosis in aortas and coronary arteries of swine with von Willebrand1s disease. Am J Pathol 102:137–145
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Fuster, V. (1983). Platelets and Atherogenesis in Normal and von Willebrand Disease Pigs. In: Schettler, F.G., Gotto, A.M., Middelhoff, G., Habenicht, A.J.R., Jurutka, K.R. (eds) Atherosclerosis VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81817-2_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-81817-2_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81819-6
Online ISBN: 978-3-642-81817-2
eBook Packages: Springer Book Archive