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Program on the Surgical Control of the Hyperlipidemias (Posch). A Secondary Intervention Trial — 4-Year Lipid Results

  • J. M. Long
  • R. B. Moore
  • J. P. Matts
  • R. L. Varco
  • H. Buchwald
Conference paper

Abstract

The Program on the Surgical Control of the Hyperlipidemias (POSCH) is a randomized secondary intervention clinical trial of the effects of lipid modification on atherosclerotic cardiovascular disease. All participants must have experienced one well documented myocardial infarction (MI), have coronary atherosclerosis, and be relatively free of other health problems. Up to 1000 patients are being enrolled in four clinical centers in the United States of America (USA), half receiving the partial ileal bypass (PIB) operation to reduce their plasma total cholesterol by an average of 30% and LDL cholesterol by an average of more than 40%, with the other half serving as controls. Participants are followed intensively for five years and less intensively thereafter. The primary endpoint for POSCH is death from any cause. A number of secondary endpoints and variables are also followed, including serial coronary arteriography. POSCH is funded by a grant from the National Heart, Lung, and Blood Institute of the USA.

Keywords

Plasma Total Cholesterol Atherosclerotic Cardiovascular Disease Data Monitoring Committee Plasma Cholesterol Reduction Plasma Total Cholesterol Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Buchwald H, Moore RB, Varco RL: Surgical treatment of the hyper- lipidemia. Circulation 49 (Suppl 1): 1–37, 1974Google Scholar
  2. 2.
    Moore RB, Buchwald H, Varco RL, POSCH Group: The effect of partial ileal bypass on plasma lipoproteins. Circulation 62: 469–76, 1980PubMedGoogle Scholar
  3. 3.
    Buchwald H: Overview of Randomized Clinical Trials of Lipid Intervention for Atherosclerotic Cardiovascular Disease. J Chronic Disease, in pressGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • J. M. Long
  • R. B. Moore
  • J. P. Matts
  • R. L. Varco
  • H. Buchwald

There are no affiliations available

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