Abstract
There are multi-center cooperative studies on the evaluation of lipid lowering effects of various drugs, such as clofibrate, pantethine, niceritrol, gamma-oryzanol and probucol. These were carried out with a double-blind design, monitoring the effects for 4 months or longer. All of these drugs were effective in reducing plasma lipid levels with negligible side effects. There are a few small scale primary prevention trials using lipid lowering drugs. The one with anabolic steroid and tocopherol was concluded with encouraging results. The second one used clofibrate. The third one with dextran sulfate is continuing. There is, however, no secondary prevention trial in Japan (Table 1).
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References
Robertson TL, Kato H, Rhoads GG et al.: Epidemiologip studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Am J Cardiol 39: 239–243, 1977
WHO Regional Office for Europe: Myocardial infarction community registers. Public Health Report 5. WHO, Copenhagen, 1977
Office of Statistics and Information, Jpn Ministry of Health and Welfare ed: Patients Survey 1979. Kosei Tokei Kyokai, Tokyo, 1981 (in Japanese)
Bureau of Tuberculosis and Chronic Disease: Jpn Ministry of Health and Welfare: An outline of results from the basic survey on cardiovascular disease. J Jpn Ass for Cerebro-Cardiovascular Dis Control 17: (1) Suppl 1–33, 1982 (in Japanese)
Higgins ITT, Kannel WB, Dawber TR: The electrocardiogram in epidemiological studies, reproducibility, validity, and international comparison. Brit J Prev Soc Med 19: 53–68, 1965
Hirota Y et al: A multivariate analysis of risk factors for cerebrovascular disease in Hysayama, Jyushu Island, Japan. Behaviormetrika No 2, 1–11, 1975
Matsuzaki T: Risk factors for stroke and myocardial infarction. In: R. Shigiya, Y. Komachi and T. Watanab eds: Nutrition and cardiovascular disease in Japanese. Hoken Dojin Sha, Tokyo, 1976. (in Japanese)
Tanaka H, Ueda Y, Date C et al: Epidemiological analysis on the stroke risk factors in the rural Japanese. Jpn J Geriatrics 13: 98–107, 1976
Shimamoto T, Komachi Y: Risk factors for cerebral stroke. Sogó Rinsho 27: 47–53, 1978. (in Japanese)
Konishi M, Iida M, Shimamoto T et al: Epidemiological and pathological studies of cerebral infarction and myocardial infarction in Japan. J Jpn Atheroscl Soc 8: 455–465, 1980. (in Japanese with English summary)
The lipid Research Clinic Program Epidemiology Committee: Plasma lipid distributions in selected North American populations: The Lipid Research Clinic Program Prevalence Study. Circulation 60: 427–429, 1979
Bureau of Nutrition, Jpn Ministry of Health and Welfare ed: Current status of national nutrition 1957. Daiichi Shuppan, Tokyo, 1978
Singman HS, Berman SN, Cowell C et al: The Anti-Coronary Club: 1957–1972. Am J Clin Nutr 33: 1183–1191, 1980
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Hatano, S. (1983). Current Japanese Situations on Secondary Prevention and Lipid Lowering Drugs. In: Schettler, F.G., Gotto, A.M., Middelhoff, G., Habenicht, A.J.R., Jurutka, K.R. (eds) Atherosclerosis VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81817-2_164
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DOI: https://doi.org/10.1007/978-3-642-81817-2_164
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