Associations Between Plasma Cholesterol, Cell Membrane Composition and Fluidity, and Retinoid Concentrations in a Normal Male Population
Reduction of plasma cholesterol levels by diet and, when appropriate, by other means is a widely accepted component of programmes to reduce coronary heart disease risk1. In preventive medicine risk/benefit considerations are even more exacting than in therapy2; hence any suggestion that low cholesterol levels might have adverse effects deserves close scrutiny. Some prospective studies have shown an increased risk of total cancer mortality3 or colon cancer deaths4 in the lowest quintile of plasma cholesterol, though this was not observed in other studies5,6.
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