Structure and Ultrastructure of the Coronary Artery Intima in Children and Young Adults Up to Age 29

  • H. C. Stary


This paper describes the intima of the coronary arteries of young human subjects as it develops and changes during maturation. The work represents a preliminary report of one part of a continuing study of the coronary arteries and aortas of the population of New Orleans in the first 29 years of life. Investigators who studied human coronary intima in the past found that it was thickened and that there was regional variation in thickness and structure. A thick intima was also reported for other arteries. Thoma (1) who studied human aortic intima with the light microscope, a century ago described and illustrated areas in which the intima was consistently thicker. He stated that the thick segments were a universal feature in human aortic development. Awareness of the fact that human arterial intima is far more than a thin and nondescript space between the basement membrane of the endothelial cells and the internal elastic lamina has, however, not been general.


Thick Filament Coronary Segment Intimal Thickening Internal Elastic Lamina Fibrous Plaque 
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  1. 1.
    Thoma R (1883) Über die Abhängigkeit der Bindegewbsneubildung in der Arterienintima von den mechanischen Bedingungen des Blutumlaufs. Virchows Arch path Anat Phsyiol 93: 443–505CrossRefGoogle Scholar
  2. 2.
    Stary HC (1982) Macrophages in coronary artery and aortic intima and in atherosclerotic lesions of children and young adults up to age 29. Proc 6th Int Symp Atherosclerosis, Springer- Verlag, Berlin-Heidelberg-New York (this volume)Google Scholar

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© Springer-Verlag Berlin Heidelberg 1983

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  • H. C. Stary

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