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Interactions Between Lipoproteins and PGI2 Under Physiologic and Pathophysiologic Conditions

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Atherosclerosis VI

Abstract

Nordøy et al. (1) have proved that LDL inhibit generation of an antiplatelet principle by cultured arterial endothelial cells and suggested it to be a PGI2-like substance. Starting out from these results we have been carring out systematic studies (2–8) to assess our working hypothesis that interactions between lipoproteins (LP) and prostacyclin (PGI2) could be relevant to the pathogenesis of atherosclerosis.

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References

  1. Nordøy A, Svensson B, Wiebe D, Hoak JC (1978) Lipoproteins and the inhibitory effect of human endothelial cells on platelet function. Circulat. Res. 43: 527–534

    PubMed  Google Scholar 

  2. Beitz J, Förster W (1980) Influence of human low density and high density lipoprotein cholesterol on the in vitro prostaglandin I2 synthetase activity. Biochim. Biophys. Acta 620: 352–355

    PubMed  CAS  Google Scholar 

  3. Beitz J, Block H-U, Hoffmann P, Förster W (1981) Influence of fatty acids and lipids from biological sources on the in vitro biosynthesis of prostaglandin I2 (PGI2). Pharmacol. Res. Commun. 13: 363–383

    Article  PubMed  CAS  Google Scholar 

  4. Beitz J, Förster W (1981) Differential influence of lipoproteins isolated from women and men on the activity of the PGI2 synthetase activity. Prostaglandins and Med. 6: 515–518

    Article  CAS  Google Scholar 

  5. Förster W, Beitz J, Hoffmann P (1980) Stimulation and inhibition of PGI2 synthetase activity by phospholipids (PL), cholesterol esters (CE), unesterified fatty acids (UFA) and lipoproteins (LDL and HDL). Artery 8: 494–500

    PubMed  Google Scholar 

  6. Beitz J, Mest H-J, Förster W (1981) Influence of linseed oil diet on the pattern of serum phospholipids in man. Acta biol. med. germ. 40: K31-K35

    PubMed  CAS  Google Scholar 

  7. Mest H-J, Beitz J, Heinroth I, Block H-U, Förster W. The influence of linseed oil diet on fatty acid pattern in phospholipids, on prostaglandin plasma level and thromboxane formation in platelets in man. Submitted to Klin.Wschr.

    Google Scholar 

  8. Förster W, Beitz J (1982) Regulation of prostacyclin synthetase activity by lipids. Pharmacol. Res. Commun. 14: 227–240

    Article  PubMed  Google Scholar 

  9. Gordon T, Kannel W, Hjortland MC, Mclamara PM (1978) Menopause and coronary heart disease. Ann. Intern. Med. 89: 157–161

    PubMed  CAS  Google Scholar 

  10. Johnson M, Reece AH, Harrison HE (1981) Abnormal arachidonic acid metabolism in diabetes: effect of drugs. In: Förster W (ed) Prostaglandins and Thromboxanes, Pergamon Press, Oxford

    Google Scholar 

  11. Halushka PV, Mayfield R, Wohltmann HJ, Rogers RC, Goldberg AK, McCoy SA, Loadholt CB, Colwell JA (1981) Increased platelet arachidonic acid metabolism in diabetes mellitus. Diabetes 30 (Supplement): 44–48

    PubMed  CAS  Google Scholar 

  12. Beitz J, Schimke E, Honigmann G, Mest H-J, Förster W (1982) In diabetics linseed oil diet does not change the influence of lipoproteins (LP) on the prostaglandin I2 (PGI2) formation. 4th Dresden Lipid Symposium, June 10–12

    Google Scholar 

  13. Brenner RR, Peluffo RO, Mercuri O, Restelli MA (1968) Effect of arachidonic acid in the alloxan-diabetic rat. Am. J. Physiol. 215: 63–70

    PubMed  CAS  Google Scholar 

  14. Dyerberg J, Bang HO, Stofferson E, Moncada S, Vane JR (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet i: 117–119

    Article  Google Scholar 

  15. Szczeklik A, Gryglewski RJ, Domagała B, Zmuda A, Hartwich J, Wozny E, Grzywacz M, Madej J, Gryglewska T (1981) Serum lipoproteins, lipid peroxides and prostacyclin biosynthesis in patients with coronary heart disease. Prostaglandins 22: 795–807

    Article  PubMed  CAS  Google Scholar 

  16. Szczeklik A, Gryglewski RJ (1980) Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries. Artery 7: 488–495

    PubMed  CAS  Google Scholar 

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Authors
  1. W. Förster
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Editors and Affiliations

  1. Medizinische Klinik, Bergheimer Str. 58, 6900, Heidelberg, Germany

    F. Gotthard Schettler , Gert Middelhoff , Andreas J. R. Habenicht  & Klara R. Jurutka , ,  & 

  2. Department of Medicine, Baylor College of Medicine, 77030, Houston, Texas, USA

    Antonio M. Gotto Jr. M.D., Ph.D.

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© 1983 Springer-Verlag Berlin Heidelberg

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Förster, W. (1983). Interactions Between Lipoproteins and PGI2 Under Physiologic and Pathophysiologic Conditions. In: Schettler, F.G., Gotto, A.M., Middelhoff, G., Habenicht, A.J.R., Jurutka, K.R. (eds) Atherosclerosis VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81817-2_121

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  • DOI: https://doi.org/10.1007/978-3-642-81817-2_121

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81819-6

  • Online ISBN: 978-3-642-81817-2

  • eBook Packages: Springer Book Archive

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