Interactions Between Lipoproteins and PGI2 Under Physiologic and Pathophysiologic Conditions

  • W. Förster


Nordøy et al. (1) have proved that LDL inhibit generation of an antiplatelet principle by cultured arterial endothelial cells and suggested it to be a PGI2-like substance. Starting out from these results we have been carring out systematic studies (2–8) to assess our working hypothesis that interactions between lipoproteins (LP) and prostacyclin (PGI2) could be relevant to the pathogenesis of atherosclerosis.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Nordøy A, Svensson B, Wiebe D, Hoak JC (1978) Lipoproteins and the inhibitory effect of human endothelial cells on platelet function. Circulat. Res. 43: 527–534PubMedGoogle Scholar
  2. 2.
    Beitz J, Förster W (1980) Influence of human low density and high density lipoprotein cholesterol on the in vitro prostaglandin I2 synthetase activity. Biochim. Biophys. Acta 620: 352–355PubMedGoogle Scholar
  3. 3.
    Beitz J, Block H-U, Hoffmann P, Förster W (1981) Influence of fatty acids and lipids from biological sources on the in vitro biosynthesis of prostaglandin I2 (PGI2). Pharmacol. Res. Commun. 13: 363–383PubMedCrossRefGoogle Scholar
  4. 4.
    Beitz J, Förster W (1981) Differential influence of lipoproteins isolated from women and men on the activity of the PGI2 synthetase activity. Prostaglandins and Med. 6: 515–518CrossRefGoogle Scholar
  5. 5.
    Förster W, Beitz J, Hoffmann P (1980) Stimulation and inhibition of PGI2 synthetase activity by phospholipids (PL), cholesterol esters (CE), unesterified fatty acids (UFA) and lipoproteins (LDL and HDL). Artery 8: 494–500PubMedGoogle Scholar
  6. 6.
    Beitz J, Mest H-J, Förster W (1981) Influence of linseed oil diet on the pattern of serum phospholipids in man. Acta biol. med. germ. 40: K31-K35PubMedGoogle Scholar
  7. 7.
    Mest H-J, Beitz J, Heinroth I, Block H-U, Förster W. The influence of linseed oil diet on fatty acid pattern in phospholipids, on prostaglandin plasma level and thromboxane formation in platelets in man. Submitted to Klin.Wschr.Google Scholar
  8. 8.
    Förster W, Beitz J (1982) Regulation of prostacyclin synthetase activity by lipids. Pharmacol. Res. Commun. 14: 227–240PubMedCrossRefGoogle Scholar
  9. 9.
    Gordon T, Kannel W, Hjortland MC, Mclamara PM (1978) Menopause and coronary heart disease. Ann. Intern. Med. 89: 157–161PubMedGoogle Scholar
  10. 10.
    Johnson M, Reece AH, Harrison HE (1981) Abnormal arachidonic acid metabolism in diabetes: effect of drugs. In: Förster W (ed) Prostaglandins and Thromboxanes, Pergamon Press, OxfordGoogle Scholar
  11. 11.
    Halushka PV, Mayfield R, Wohltmann HJ, Rogers RC, Goldberg AK, McCoy SA, Loadholt CB, Colwell JA (1981) Increased platelet arachidonic acid metabolism in diabetes mellitus. Diabetes 30 (Supplement): 44–48PubMedGoogle Scholar
  12. 12.
    Beitz J, Schimke E, Honigmann G, Mest H-J, Förster W (1982) In diabetics linseed oil diet does not change the influence of lipoproteins (LP) on the prostaglandin I2 (PGI2) formation. 4th Dresden Lipid Symposium, June 10–12Google Scholar
  13. 13.
    Brenner RR, Peluffo RO, Mercuri O, Restelli MA (1968) Effect of arachidonic acid in the alloxan-diabetic rat. Am. J. Physiol. 215: 63–70PubMedGoogle Scholar
  14. 14.
    Dyerberg J, Bang HO, Stofferson E, Moncada S, Vane JR (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet i: 117–119CrossRefGoogle Scholar
  15. 15.
    Szczeklik A, Gryglewski RJ, Domagała B, Zmuda A, Hartwich J, Wozny E, Grzywacz M, Madej J, Gryglewska T (1981) Serum lipoproteins, lipid peroxides and prostacyclin biosynthesis in patients with coronary heart disease. Prostaglandins 22: 795–807PubMedCrossRefGoogle Scholar
  16. 16.
    Szczeklik A, Gryglewski RJ (1980) Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries. Artery 7: 488–495PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • W. Förster

There are no affiliations available

Personalised recommendations