Measurements of C Apoprotein Kinetics in Man

  • P. J. Nestel
  • N. H. Fidge
  • M. W. Huff
Conference paper

Abstract

There have been few in vivo studies of C apoprotein metabolism in man. Berman et al. (1) have carried out analyses of total C apoprotein kinetics following reinjection of radiolabelled VLDL. The simulated model resembled that for VLDL B apoprotein metabolism, comprising a series of 4 delipidation steps of the triglyceriderich particles during which C peptides become transferred to HDL, producing a final IDL particle which retains a small fraction of the original VLDL C apoprotein. The model did not identify the lipoprotein with which the C peptides entered the circulation, both VLDL and HDL fitting the data, but removal of C protein appeared to occur with HDL. The major aspects of this in vivo model coincided with findings observed consistently during the in vitro lipolysis of VLDL, and with studies of isolated cells and organs.

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References

  1. 1.
    Berman M, Hall M, Levy RI, Eisenberg S, Bilheimer DW, Phair RD and Goebel RH (1978) Metabolism of apo B and apo C lipoproteins in man: Kinetic studies in normal and hyperlipoproteinemic subjects J Lipid Res 19: 38–56PubMedGoogle Scholar
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    Huff MW, Fidge NH, Nestel PJ, Billington T and Watson B (1981) Metabolism of C-apolipoproteins: kinetics of CII, CIII1 and C-III2, and VLDL-apolipoprotein B in normal and hyperlipo-proteinemic subjects J Lipid Res 22: 1235–1246PubMedGoogle Scholar
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    Huff MW and Nestel PJ (1982) Metabolism of apolipoproteins CII, CIII1, CIII2 and VLDL-B in human subjects consuming high carbohydrate diets Metabolism (in press)Google Scholar
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    Nestel PJ, Reardon MF and Fidge NH (1979) Very low density lipoprotein-B apoprotein kinetics in human subjects Cir Res 45: 35–41Google Scholar
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    Reardon MF, Fidge NH and Nestel PJ (1978) The catabolism of very low density lipoprotein B apoprotein in man J Clin Invest 61: 850–860PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • P. J. Nestel
  • N. H. Fidge
  • M. W. Huff

There are no affiliations available

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