Abstract
We know that tumours grow but our understanding of the dynamic changes which lead to this growth is incomplete, particularly in the case of human cancer. Precise and accurate data on human tumours are unfortunately hard to obtain due to the practical and ethical constraints existing in human cancer studies. In this review an attempt will be made to draw some general conclusions about the cell kinetics of colorectal cancer from information already available. In addition, some areas of current and possible future interest will be discussed.
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References
Aherne WA, Camplejohn RS, Wright NA (1977a) An introduction to cell population kinetics. Eward Arnold, London
Aherne WA, Camplejohn RS, Al-Wiswasy M, Ford D, Kellerer AM (1977b) Assessment of inherent fluctuations of mitotic and labelling indices of human tumours. Br J Cancer 36: 577–582
Barranco SC, Ho DHW, Drewinko B, Romsdahl MM, Humphrey RM (1972) Differential sensitivities of human melanoma cells grown in vitro to arabinosylcytosine. Cancer Res 32: 2733–2736
Bleiberg H, Galand P (1976) In vitro autoradiographic determination of cell kinetic parameters in adenocarcinomas and adjacent healthy mucosa of the human colon and rectum. Cancer Res 36: 325–328
Bleiberg H, Salhadin A, Galand P (1977) Cell cycle parameters in human colon. Cancer 39: 1190–1194
Bone G, Camplejohn RS (1975) Rectal carcinoma. A two-part study of tumour proliferation and host cellular immunity Am J Proctol 26: 65–76
Buick RN, Fry SE, Salmon SE (1980) Application of in vitro soft agar techniques for growth of tumor cells to the study of colon cancer. Cancer 45: 1238–1242
Camplejohn RS (1974) Cell population kinetics of human tumours. PhD thesis, University of Newcastle-upon-Tyne
Camplejohn RS, Bone G, Aherne W (1973) Cell proliferation in rectal carcinoma and rectal mucosa. A stathmokinetic study. Eur J Cancer 9: 577–581
Chang WWL (1978) Histogenesis of symmetrical 1,2 dimethylhydrazine-induced neoplasms of the colon in the mouse. J Natl Cancer Inst 60: 1405–1418
Chang WWL, Leblond CP (1971) Renewal of the epithelium in the descending colon of the mouse. I. Presence of three cell populations: vacuolated-columnar, mucous and argentaffin Am J Anat 131: 73–100
Courtenay VD, Selby PJ, Smith IE, Mills J, Peckham MJ (1978) Growth of human tumour cell
colonies from biopsies using two soft-agar techniques. Br J Cancer 38: 77–81
Fidler IJ (1978) Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38: 2651–2660
Gray JM, Pierce GB (1964) Relationship between growth rate and differentiation of melanoma in vivo. J Natl Cancer Inst 32: 1201–1210
Hakanson L, Trope C (1974) On the presence within tumours of clones that differ in sensitivity to cytostatic drugs. Acta Pathol Microbiol Scand [A] 82: 35–40
Heppner GH, Dexter DL, Denucci T, Miller FR, Calabresi P (1978) Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor. Cancer Res 38: 3758–3763
Hermens AF, Barendsen GW (1967) Cellular proliferation patterns in an experimental rhabdomyosarcoma in the rat. Eur J Cancer 3: 361–369
Lesher S, Schiffer LM, Phanse M (1977) Human colonic tumor cell kinetics. Cancer 40: 2706–2709
Lieb LM, Lisco H (1966) In vitro uptake of tritiated thymidine by carcinoma of the human colon. Cancer Res 26: 733–740
Lipkin M, Bell B, Stalder G, Troncale F (1970) The development of abnormalities of growth in colonic epithelial cells of man. In: Burdette W (ed) Carcinoma of the colon and antecedent epithelium. Thomas, Springfield, pp 213–221
Petersen SE, Bichel P, Lorentzen M (1978) Flow-cytometric demonstration of tumour-cell subpopulations with different DNA content in human colo-rectal carcinoma. Eur J Cancer 15: 383–386
Salmon SE, Hamburger AW, Soehnlen B, Durie BGM, Alberts DS, Moon TE (1978) Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs. N Engl J Med 298: 1321–1327
Spratt JS (1970) Gross rates of growth of colonic neoplasms and other variables affecting medical decisions and prognosis. In: Burdette W (ed) Carcinoma of the colon and antecedent epithelium. Thomas, Springfield, pp 222–229
Steel GG (1968) Cell loss from experimental tumours. Cell Tissue Kinet 1: 193–207 Steel GG ( 1977 ) Growth kinetics of tumours. Clarendon Press, Oxford
Sunter JP, Wright NA, Appleton DR (1978) Cell population kinetics in the epithelium of the colon of the male rat. Virchows Arch B [Cell Pathol] 26: 275–287
Welin S, Youker J, Spratt JS (1963) The rates and patterns of growth of 375 tumors of the large intestine and rectum observed serially by double contrast enema study ( Malmö technique ). Am J Roentgenol 90: 673–687
Wolberg WH, Ansfield FJ (1971) The relation of thymidine labeling index in human tumours in vitro to the effectiveness of 5-fluorouracil chemotherapy. Cancer Res 31: 448–450
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© 1982 Springer-Verlag Berlin · Heidelberg
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Camplejohn, R.S. (1982). Cell Kinetics. In: Duncan, W. (eds) Colorectal Cancer. Recent Results in Cancer Research, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81802-8_3
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DOI: https://doi.org/10.1007/978-3-642-81802-8_3
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