Abstract
The descriptive epidemiology of colorectal cancer in England and Wales presented in some detail in Chapter 1 gives little clue to its aetiology. Its incidence shows that there are no marked differences according to social class or to region of the country, and no marked change over time. Few occupational associations have been reported apart from asbestos exposure, and this has not been a consistent observation. Moreover, the finding by Newhouse and Wagner (1969) that some peritoneal mesotheliomas in asbestos workers were misdiagnosed and described on death certificates as colon cancers raises further doubts about the association. Nevertheless, the marked international variation in incidence together with the much lower incidence among blacks in Africa than in those in the United States point to the importance of environmental factors in the causation of these cancers.
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References
Amstrong B, Doll R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15: 617–631
Bingham S, Williams DRH, Cole TJ, James WPT (1979) Dietary fibre and regional large-bowel cancer mortality in Britain. Br J Cancer 40: 456–463
Bjelke E (1973) Epidemiologic studies of cancer of the stomach, colon and rectum, vols 1–4. PhD thesis, University of Minnesota, Ann Arbor, Michigan, USA
Bjelke E (1980) Epidemiology of colorectal cancer with emphasis on diet. In: Davis W, Harrap KR, Stathopoulós F (eds) Human cancer. Its characterisation and treatment. Proceedings of the 8th International Symposium on the Biological Characterisation of Human Tumours, Aetiology 19
Athens, May 1979. Excerpta Medica, Amsterdam Oxford Princetown, pp 158–174 (International congress series no. 484 )
Boyd JT, Doll R (1954) Gastrointestinal cancer and the use of liquid paraffin Br J Cancer 8: 231–237
Breslow NE, Enstrom JE (1974) Geographic correlation between cancer mortality rates and alcohol-tobacco consumption in the United States. J Natl Cancer Inst 53: 631–639
Burkitt DP (1971) Epidemiology of cancer of the colon and rectum. Cancer 28: 3–13
Dean G, MacLennon R, McLoughlin H, Shelley E (1979) Causes of death of blue-collar workers at a Dublin brewery, 1954–1973. Br J Cancer 40: 581–589
Enstrom JE (1975) Colorectal cancer and consumption of beef and fat. Br J Cancer 32: 432–439
Enstrom JE (1977) Colorectal cancer and beer drinking. Br J Cancer 35: 647–683
Finegold SM, Flora DJ, Atteberg JR, Sutter VL (1975) Fecal bacteriology of colonic polyp patients and control patients. Cancer Res 35: 3407–3417
Graham S, Dayal H, Swanson M, Mittelman A, Wilkinson G (1978) Diet in the epidemiology of cancer of the colon and rectum. J Natl Cancer Inst 61: 709–714
Haenszel W, Kurihara M (1968) Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst 40: 43–68
Haenszel W, Berg JW, Segi M, Kurihara M, Locke FH (1973) Large bowel cancer in Hawaiian Japanese. J Natl Cancer Inst 51: 1765–1779
Higginson J (1966) Etiologic factors in gastrointestinal cancer in man J Natl Cancer Inst 37: 527–345
Hill MJ (1971) The effect of some factors on the faecal concentration of acid steroids, neutral steroids and urobilins J Pathol 104: 239–245
Hill MJ, Drasar BS, Ares VC, Crowther JS, Hawkesworth GM, Williams REO (1971) Bacteria and aetiology of cancer of the large bowel. Lancet 1: 95–100
International Agency for Research on Cancer, Intestinal Microecology Group (1977) Dietary fibre, transit time, faecal bacteria, steroids and colon cancer in two Scandinavian populations. (Report) Lancet 2: 207–211
Jensen OM (1979) Cancer morbidity and causes of death among Danish brewery workers. Int J Cancer 23: 454–463
Kinlen LJ (1980) Mortality in relation to abstinence from meat in certain orders of religious sisters in Britain. Cancer incidence in defined populations. Cold Spring Harbor Laboratory, Cold Spring Harbor (Banbury report no. 4 )
Lovett E (1976) Family studies in cancer of the colon and rectum. Br J Surg 63: 13–18
Lyon JL, Sorenson AW (1978) Colon cancer in a low-risk population. Am J Clin Nutr 31: 5227–5230
Macklin M (1960) Inheritance of cancer of the stomach and large intestine in man. J Natl Cancer Inst 24: 551–571
Mastromarino AJ, Reddy BS, Wynder EL (1978) Fecal profiles of anaerobic microflora of large bowel cancer patients and patients with non-hereditary large bowel polyp. Cancer Res 35: 3407–3417
Modan B, Barell V, Lubin F, Modan M, Greenberg RA (1975) Low-fibre intake as an etiologic factor in cancer of the colon. J Natl Cancer Inst 55: 15–18
Mudd DG, McKelvey STD, Elmore DT (1978) Faecal bile acid concentrations in patients at increased risk of large bowel cancer. (Abstract) Br J Surg 65: 357
Mudd DG McKelvey STD, Norwood W, Elmore DT (1979) Carcinoma of the large bowel and faecal bile acids. (Abstract) Br J Surg 66: 355
Murrey WR, Blackwood A, Trotter JM, Calman KC, MacKay C (1980) Faecal bile acids and clostridia in the aetiology of colorectal cancer. Br J Cancer 41: 923–928
Newhouse ML, Wagner JC (1969) Validations of death certificate in asbestos workers. Br J Indust Med 26: 302–307
Paymaster JC, Sanghri LD, Gangadharan P (1968) Cancer in the gastrointestinal tract in Western India. Cancer 21: 279–288
Phillips RI (1975) Role of life style and dietary habits in risk of cancer among Seventh-Day Adventists. Cancer Res 35: 3513–3522
Smith RL (1956) Recorded and expected mortality among Japanese of the United States and Hawaii, with specific reference to cancer. J Natl Cancer Inst 17: 459–473
Staszewski J, Haenszel W (1968) Cancer mortality among the Polish-born in the United States. J Natl Cancer Inst 35: 291–297
Stocks P (1958) Cancer incidence in North Wales and Liverpool region in relation to habits and environment. British Empire Cancer Campaign, London (35th annual report, suppl 2: 2 )
Watne AL, Lai HYL, Mance T, Core S (1976) Fecal steroids and bacterial flora in patients with polyposis coli. Am J Surg 131: 42–46
Wattenberg LW (1971) Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Cancer 28: 99–102
Wattenberg LW, Loub WD (1978) Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occuring indoles. Cancer Res 38: 1410–1413
Woolf CM (1958) A genetic study of carcinoma of the large intestine. Am J Hum Genet 10: 42–47
Wynder E, Shigematsu T (1967) Environmental factors of cases of the colon and rectum. Cancer 20: 1520–1561
Wynder E, Kajitani T, Ishikawa S, Dodo H, Takono A (1969) Environmental factors of cancer of the colon and rectum. II. Japanese epidemiological data. Cancer 23: 1210–1220
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© 1982 Springer-Verlag Berlin · Heidelberg
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Kinlen, L.J. (1982). Aetiology. In: Duncan, W. (eds) Colorectal Cancer. Recent Results in Cancer Research, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81802-8_2
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